Early cumulus cell removal increases cumulative live birth rate while having no negative effect on the malformation rate in in vitro fertilization: a propensity score-matched cohort study

Abstract

The aim of this study was to investigate the e cacy and safety of early cumulus cell removal (ECCR) during human in vitro fertilization (IVF). MethodsA retrospective analysis was performed between January 2011 and December 2019. The study enrolled 1,131 couples who underwent IVF treatment with ECCR. After propensity score matching at a 1:1 ratio, 1,131 couples who underwent overnight coincubation of gametes were selected. The main outcome measure was the cumulative live birth rate. Secondary outcome measures included the cumulative pregnancy rate, polyspermy rate, available embryo rate, miscarriage rate, malformation rate, time to live birth, and oocyte-to-baby rate. ResultsThere were no signi cant differences found between the two groups in the polyspermy rate, available embryo rate, miscarriage rate, time to live birth, oocyte-to-baby rate, and neonatal congenital anomalies rate. The results of the study showed that ECCR was associated with a signi cantly higher cumulative live birth rate and cumulative pregnancy rate, along with a signi cantly lower fertilization rate. ConclusionECCR tended to confer increased cumulative live birth rate and had no negative effect on the neonatal malformation rate. What does this study adds to the clinical work?Early cumulus cell removal was associated with higher cumulative live birth rate while has no difference in term of neonatal congenital anomalies