Early detection of pulp necrosis and dental vitality after traumatic dental injuries in children and adolescents by 3-Tesla magnetic resonance imaging

Assaf, Alexandre T; Zrnc, Tomislav; Remus, Chressen Catharina; Khokale, Arun; Habermann, Christian R.; Schulze, Dirk; Fiehler, Jens; Heiland, Max; Sedlacik, Jan; Friedrich, Reinhard E

doi:10.1016/j.jcms.2015.06.010

Cited by 36 publications

(45 citation statements)

References 33 publications

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“…Therefore, alternative objective diagnosis of the regenerated tissue was further performed by MRI. MRI provides high-resolution images, allowing fine discrimination between blood-filled structures of dental pulp and the adjacent tooth [24, 25]. Soft tissue abnormalities produced by inflammation caused by increased water content are ideally displayed by MRI [26, 27].…”

Section: Discussionmentioning

confidence: 99%

“…Soft tissue abnormalities produced by inflammation caused by increased water content are ideally displayed by MRI [26, 27]. MRI has been demonstrated to be a feasible means to visualize changes in the dental pulp, including reperfusion and revitalization of the affected teeth with traumatic dental injury after clinical treatment [25]. Our previous preclinical study demonstrated that the MRI signal intensity (SI) in the regenerated teeth at 24 weeks after cell transplantation was similar to that in normal teeth, and was significantly higher compared to that in control non-regenerated teeth without cell transplantation, suggesting the potential usefulness of MRI to serially assess the regeneration of pulp tissue [28].…”

Section: Discussionmentioning

confidence: 99%

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Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

et al. 2017

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BackgroundExperiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safety, potential efficacy, and feasibility of autologous transplantation of MDPSCs in pulpectomized teeth.MethodsFive patients with irreversible pulpitis were enrolled and monitored for up to 24 weeks following MDPSC transplantation. The MDPSCs were isolated from discarded teeth and expanded based on good manufacturing practice (GMP). The quality of the MDPSCs at passages 9 or 10 was ascertained by karyotype analyses. The MDPSCs were transplanted with granulocyte colony-stimulating factor (G-CSF) in atelocollagen into pulpectomized teeth.ResultsThe clinical and laboratory evaluations demonstrated no adverse events or toxicity. The electric pulp test (EPT) of the pulp at 4 weeks demonstrated a robust positive response. The signal intensity of magnetic resonance imaging (MRI) of the regenerated tissue in the root canal after 24 weeks was similar to that of normal dental pulp in the untreated control. Finally, cone beam computed tomography demonstrated functional dentin formation in three of the five patients.ConclusionsHuman MDPSCs are safe and efficacious for complete pulp regeneration in humans in this pilot clinical study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

et al. 2017

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“…Recent advances in dental MRI applying dedicated sequence protocols and head coils have led to improved image quality and broadened variety of indications. 33,34 Even though CBCT is at present not considered a standard tool in oncologic imaging, a recent study showed a similar or even superior image quality of CBCT compared with CT using equalized dose levels, predicting a growing overlap of indications for CBCT and CT when it comes to diagnostics of hard-tissue structures. 35 In addition, Hendrikx et al 36 pointed out its potential when it comes to diagnostics of mandibular invasion or erosion in patients with oral squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Artefacts in multimodal imaging of titanium, zirconium and binary titanium–zirconium alloy dental implants: anin vitrostudy

Smeets¹,

Schöllchen²,

Gauer³

et al. 2017

Dentomaxillofacial Radiology

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MRI allows for an excellent image contrast and limited artefacts in patients with zirconium implants. CT and CBCT examinations are less affected by artefacts from titanium and titanium-zirconium alloy implants compared with MRI. The knowledge about differences of artefacts through different implant materials and image modalities might help support clinical decisions for the choice of implant material or imaging device in the clinical setting.

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“…MRI visualizes pulp morphology and periapical tissues which are main focuses of endodontics. It may also provide information about the vitality of pulp [6]. It can be an alternative to electrical pulp tests.…”

Section: Magnetic Resonance Imaging In Endodonticsmentioning

confidence: 99%

“…There are a few disadvantages of MRI. Image artifacts can be seen often due to metal materials and patient movements [6]. Also, MRI examinations can be expensive.…”

Section: Magnetic Resonance Imaging In Endodonticsmentioning

confidence: 99%

Magnetic Resonance Imaging and Its Applications in Dentistry: A review

2019

JCRC

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Magnetic resonance imaging (MRI) is currently one of the essential imaging methods in medicine. Since it is a noninvasive method that does not use ionizing radiation, its applications are getting more and more attention in the dentistry field. MRI is specifically used for the evaluation of soft tissues. Temporomandibular disorders, paranasal sinuses, determination of lesion contents and endodontics are just some of the application subjects. The aim of this review is to inform dentists and oral surgeons about the application fields of MRI.

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Early detection of pulp necrosis and dental vitality after traumatic dental injuries in children and adolescents by 3-Tesla magnetic resonance imaging

Cited by 36 publications

References 33 publications

Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

Artefacts in multimodal imaging of titanium, zirconium and binary titanium–zirconium alloy dental implants: anin vitrostudy

Magnetic Resonance Imaging and Its Applications in Dentistry: A review

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