Early Diagnosis of Large Vessel Vasculitis: Usefulness of Positron Emission Tomography With Computed Tomography

Castellanos, María del Carmen Pacheco; Vega, Mauricio Mínguez; Caballero, A. Martínez; Gonzálvez, Maria Pilar Bernabeu

doi:10.1016/j.reumae.2013.01.005

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…In addition, Novikov et al demonstrated that PET can be a valuable diagnostic tool in patients with medium vessel involvement (64) and, thus, may contribute to depict inflammation of the vessel walls in patients with inconclusive diagnostic results (65). Of note, FDG-PET was previously applied to follow up and monitor disease activity in vasculitis (66, 67). However, small-vessel involvement cannot be detected by this imaging modality (68).…”

Section: Potential New Diagnostic Biomarkersmentioning

confidence: 99%

Primary Angiitis of the Central Nervous System: New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid

et al. 2019

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Primary angiitis of the central nervous system (PACNS) is an inflammatory brain disease affecting the medium and small vessels of the CNS. Although recent data of patients with PACNS have advanced the understanding of the disease, the diagnosis remains challenging. Clinical presentation of PACNS is broad and unspecific and the majority of the diagnostic approaches are hallmarked by a low specificity. Thus, PACNS is commonly misdiagnosed. In addition, due to its potential aggressive course which may be altered by an adequate immunosuppressive treatment, delineation from other vasculopathies and PACNS mimics is crucial. New diagnostic tools and biomarkers which increase specificity and facilitate the diagnosis for patients with suspected PACNS are highly desirable. This short review summarizes the current procedures within the diagnostic process and aims to illustrate its difficulties and challenges. Furthermore, it highlights emerging biomarkers in the cerebrospinal fluid and peripheral venous blood as well as novel potential imaging tools that may corroborate the diagnosis. With new imaging techniques and a panel of biomarkers the certainty of the diagnosis may be increased and diagnostic processes more accelerated in the future.

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Section: Potential New Diagnostic Biomarkersmentioning

confidence: 99%

Primary Angiitis of the Central Nervous System: New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid

et al. 2019

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“…Por lo tanto, la principal indicación del PET-TC actual en el diagnóstico inicial de la arteritis de grandes vasos es la confirmación de afección inflamatoria vascular cuando la presentación clínica o los hallazgos de otras técnicas de imagen ofrezcan información inespecífica. Será necesario posteriormente completar el estudio con una técnica específica, como angio-TC o angio-RM, que permita describir las alteraciones angiográficas 11 .…”

Section: Discussionunclassified

Arteritis de Takayasu como hallazgo incidental en un paciente con enfermedad celiaca: la importancia de la tomografía computarizada por emisión de positrones

Moreno-Sánchez,

Molina-Herranz,

Aguilar-de-la-Red

et al. 2023

BMHIM

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Introducción: La arteritis de Takayasu es una vasculitis de grandes vasos que afecta a las arterias elásticas de gran calibre, fundamentalmente la aorta y sus ramas principales. Ocurre frecuentemente en mujeres entre los 20-30 años, por lo que es muy infrecuente en la edad pediátrica. Caso clínico: Se presenta el caso de una paciente de 15 años en seguimiento desde los 9 años por enfermedad celiaca. A los 13 años se detectó anemia de trastornos crónicos, elevación de proteína C reactiva y velocidad de sedimentación globular. La paciente permaneció en todo momento asintomática. Tras descartar otros procesos, se solicitó tomografía computarizada por emisión de positrones (PET-TC), donde se detectaron lesiones compatibles con vasculitis de grandes vasos. La valoración por Cardiología evidenció un aneurisma en coronaria derecha. Se realizó angio-TC, que sugirió arteritis de Takayasu tipo III. Conclusiones: Es frecuente un retraso en el diagnóstico de la arteritis

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“…For example; positron emission tomography (PET)/CT helps confirm the presence of large vessel vasculitis when clinical findings and other imaging findings are nonspecific and it can help in monitoring these patients to detect disease activity [13] , [14] , [15] , [16] .…”

Section: Discussionmentioning

confidence: 99%

Fused 18F-Choline PET/MRI: A potential non-invasive biomarker imaging tool in cerebral vasculitis

Abouzied

Alsalloum

Alharbi

et al. 2021

Radiology Case Reports

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Primary CNS vasculitis is an inflammatory brain disease commonly misdiagnosed affecting the medium and small vessels of the CNS. Due to its broad and non-specific clinical and radiological manifestations; Its diagnosis remains challenging. New diagnostic tools and biomarkers which increase specificity and facilitate the diagnosis for patients with suspected vasculitis are highly desirable to enable physicians to start therapy that can alter its potential aggressive course like immunosuppressant. This case report highlights the potential role of 18 F-choline PET/MRI as a novel imaging tool that might help in the right clinical scenario in the diagnosis of this disease. Furthermore, it speculates on its secondary role in monitoring the response to immunosuppressant therapy.

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Early Diagnosis of Large Vessel Vasculitis: Usefulness of Positron Emission Tomography With Computed Tomography

Cited by 5 publications

References 11 publications

Primary Angiitis of the Central Nervous System: New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid

Primary Angiitis of the Central Nervous System: New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid

Arteritis de Takayasu como hallazgo incidental en un paciente con enfermedad celiaca: la importancia de la tomografía computarizada por emisión de positrones

Fused 18F-Choline PET/MRI: A potential non-invasive biomarker imaging tool in cerebral vasculitis

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