Early donor management increases the retrieval rate of hearts for transplantation in marginal donors†

Abuanzeh, Razi; Hashmi, Faisal; Dimarakis, Ioannis; Khasati, Noman; Machaal, Ali; Yonan, Nizar; Venkateswaran, Rajamiyer

doi:10.1093/ejcts/ezu135

Cited by 19 publications

(7 citation statements)

References 20 publications

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“…105 Early, targeted management of the potential donor can increase the number of available donor hearts without a deleterious effect on post-transplant outcomes. 107 A number of studies demonstrate improved organ donation rates after a longer period of donor stabilization. 108−111 A dedicated team in an ICU setting should manage the pediatric cardiac donor to maximize the probability of successful transplantation.…”

Section: Electrocardiogram (Ecg)mentioning

confidence: 99%

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Kirk

Dipchand

Davies

et al. 2020

The Journal of Heart and Lung Transplantation

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Section: Electrocardiogram (Ecg)mentioning

confidence: 99%

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Kirk

Dipchand

Davies

et al. 2020

The Journal of Heart and Lung Transplantation

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“…Many donor lungs have become unsuitable for transplantation at the time of offer due to catecholamine and inflammatory responses causing detrimental damage to the donor lungs ( 14 ). During the period between confirmation of brain death and organ retrieval, attention to detail and optimization may improve organ function, thereby increasing the utilization rate ( 15 16 17 18 19 ). Early donor management can reduce post brain stem death hormonal and inflammatory changes and therefore improve donor organ function and increase the number of available lungs for transplantation.…”

Section: Discussionmentioning

confidence: 99%

Current Status and Future of Lung Donation in Korea

et al. 2017

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Lung transplantation is the only effective treatment option for patients with end-stage lung disease. However, donor organ shortage makes timely transplant not possible for all patients, especially in Korea. We investigated the number and utilization of donor lungs by retrospectively reviewing all donor organs registered in the Korea Network for Organ Sharing database from March 2012 to March 2016. The donors were stratified into 4 groups by donor acceptability criteria. A total of 1,304 donors were included. Of those, 295 brain-dead donors (22.6%) consented to lung donation. Among these consented donors, 168 donors (12.9%) were retrieved for lung transplant. Retrieval rate was very low compared with that of the kidney (93.9%), liver (86.3%), and heart (27.3%). The characteristics of utilized donor lungs were: mean age, 40.5 years (range: 18 to 63 years); mean partial pressure of oxygen, 356.5 mmHg; mean smoking history, 5.9 pack-years; and mean body mass index, 22.6 kg/m2. The proportion of donors with acceptable condition of the transplanted lungs was only 39.3% (ideal 19, standard 47, marginal 70, unusable 32). Among brain-dead patients who denied to donate lungs (n = 1,009), 82 were potentially acceptable donors (ideal 19, standard 63), which was equal to half of actually transplanted lung donations. Many potential donor lungs, which are currently excluded, may be successfully used in lung transplantation in Korea. The available lung donors must be actively selected and managed to maximize the utilization of this precious resource.

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“…Many ODM procedures that are meant to maintain optimal organ function have increased in complexity. This implies that the involvement of an experienced intensive care physician early in the donation process is crucial for the conversion of each and every donor . Another factor that could explain the success of the OPC is the conversion of profoundly marginal donors.…”

Section: Discussionmentioning

confidence: 99%

The First 2 Years of Activity of a Specialized Organ Procurement Center: Report of an Innovative Approach to Improve Organ Donation

Marsolais

Durand

Charbonney

et al. 2017

American Journal of Transplantation

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The number of patients requiring organ transplants continues to outgrow the number of organs donated each year. In an attempt to improve the organ donation process and increase the number of organs available, we created a specialized multidisciplinary team within a specialized organ procurement center (OPC) with dedicated intensive care unit (ICU) beds and operating rooms. The OPC was staffed with ICU nurses, operating room nurses, organ donor management ICU physicians, and multidisciplinary staff. All organ donors within a designated geographic area were transferred to and managed within the OPC. During the first 2 years of operation, 126 patients were referred to the OPC. The OPC was in use for a total of 3527 h and involved 253 health workers. We retrieved 173 kidneys, 95 lungs, 68 livers, 37 hearts, and 13 pancreases for a total of 386 organs offered for transplantation. This translates to a total of 124.6 persons transplanted per million population, which compares most favorably to recently published numbers in developed countries. The OPC clearly demonstrates potential to increase the number of deceased donor organs available for transplant. Further studies are warranted to better understand the exact influence of the different components of the OPC on organ procurement.

show abstract

Early donor management increases the retrieval rate of hearts for transplantation in marginal donors†

Cited by 19 publications

References 20 publications

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Current Status and Future of Lung Donation in Korea

The First 2 Years of Activity of a Specialized Organ Procurement Center: Report of an Innovative Approach to Improve Organ Donation

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