Early dynamic changes to monocytes following major surgery are associated with subsequent infections
Timothy Arthur Chandos Snow,
Alessia V. Waller,
Richard Loye
et al.
Abstract:BackgroundPost-operative infections are a common cause of morbidity following major surgery. Little is understood about how major surgery perturbs immune function leading to heightened risk of subsequent infection. Through analysis of paired blood samples obtained immediately before and 24 h following surgery, we evaluated changes in circulating immune cell phenotype and function across the first 24 h, to identify early immune changes associated with subsequent infection.MethodsWe conducted a prospective obser… Show more
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