Early Evaluation of Relative Changes in Tumor Stiffness by Shear Wave Elastography Predicts the Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer

Jing, Hui; Cheng, Wen; Li, Zi-Yao; Li, Ying; Wang, Qiu-Cheng; Wu, Tong; Tian, Jiawei

doi:10.7863/ultra.15.08052

Cited by 57 publications

(54 citation statements)

References 31 publications

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“…The described method can potentially be useful both as a treatment evaluation tool to probe stiffness of ablated tissue, and as a diagnostic tool to efficiently investigate differences in mechanical properties between, for example, malignant and healthy tissue. 48,49 2 | METHODS…”

Section: Magnetic Resonance In Medicinementioning

confidence: 99%

“…In the porcine brain it is shown that the measured displacement decreases after ablation due to increased tissue stiffness. The described method can potentially be useful both as a treatment evaluation tool to probe stiffness of ablated tissue, and as a diagnostic tool to efficiently investigate differences in mechanical properties between, for example, malignant and healthy tissue …”

Section: Introductionmentioning

confidence: 99%

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Multiple‐point magnetic resonance acoustic radiation force imaging

Odéen

Bever

Hofstetter

et al. 2018

Magnetic Resonance in Med

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Purpose: To implement and evaluate an efficient multiple-point MR acoustic radiation force imaging pulse sequence that can volumetrically measure tissue displacement and evaluate tissue stiffness using focused ultrasound (FUS) radiation force. Methods: Bipolar motion-encoding gradients were added to a gradient-recalled echo segmented EPI pulse sequence with both 2D and 3D acquisition modes. Multiple FUS-ON images (FUS power > 0 W) were interleaved with a single FUS-OFF image (FUS power = 0 W) on the TR level, enabling simultaneous measurements of volumetric tissue displacement (by complex subtraction of the FUS-OFF image from the FUS-ON images) and proton resonance frequency shift MR thermometry (from the OFF image). Efficiency improvements included partial Fourier acquisition, parallel imaging, and encoding up to 4 different displacement positions into a single image. Experiments were performed in homogenous and dual-stiffness phantoms, and in ex vivo porcine brain. Results: In phantoms, 16-point multiple-point magnetic resonance acoustic radiation force imaging maps could be acquired in 5 s to 10 s for a 2D slice, and 60 s for a 3D volume, using parallel imaging and encoding 2 displacement positions/image. In ex vivo porcine brain, 16-point multiple-point magnetic resonance acoustic radiation force imaging maps could be acquired in 20 s for a 3D volume, using partial Fourier and parallel imaging and encoding 4 displacement positions/image. In 1 experiment it was observed that tissue displacement in ex vivo brain decreased by approximately 22% following FUS ablation. Conclusion: With the described efficiency improvements it is possible to acquire volumetric multiple-point magnetic resonance acoustic radiation force imaging maps, with simultaneous proton resonance frequency shift MR thermometry maps, in clinically acceptable times.

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Section: Magnetic Resonance In Medicinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple‐point magnetic resonance acoustic radiation force imaging

Odéen

Bever

Hofstetter

et al. 2018

Magnetic Resonance in Med

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show abstract

“…These results could be used for imaging methods such as MRE for in vivo treatment evaluation. In fact, elastography method using ultrasound has been used to assess the relative change of the tumor stiffness to predict the early treatment response to chemotherapy [42]. In addition, unlike the ex vivo testing methods such as TUNEL stain that takes days of work to be fixed, stained, and observed, biomechanical characterization methods provide a potentially more efficient and convenient alternative.…”

Section: Treatment Evaluationsmentioning

confidence: 99%

Evaluation of the Laser-Induced Thermotherapy Treatment Effect of Breast Cancer Based on Tissue Viscoelastic Properties

Chen

Zhou

Qiu

et al. 2018

Journal of Engineering and Science in Medical Diagnostics and Therapy

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Photothermal therapy (PTT) has been emerging as an effective, minimally invasive approach to treat cancers. However, a method to quantitatively evaluate the treatment effect after laser-induced thermotherapy (LITT) is needed. In this study, we used 808 nm laser radiation with three different power densities to treat the breast cancer tissue from 4T1 cell lines in a mouse model. The viscoelastic properties of the treated cancer tissues were characterized by a two-term Prony series using a ramp-hold indentation method. We observed that instantaneous shear modulus G0 was significantly higher for the treated cancer tissues than that of the untreated tissue when treated with a power density of 1.5 W/cm2, but significantly lower with a power density of 2.5 W/cm2. The long-term shear modulus G∞ was also significantly higher for the cancer tissue at 1.5 W/cm2, compared to the untreated tissue. The treatment effects were verified by estimating the cell apoptosis rate using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Our results indicate that the viscoelastic properties of the tissue could potentially be used as biomarkers for evaluating the LITT treatment effect. In addition, we also observed a strain-independent behavior of the treated cancer tissue, which provided useful information for applying in vivo imaging method such as magnetic resonance elastography (MRE) for treatment evaluation based on biomechanical properties.

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“…В зарубежной литературе нам встретились лишь 6 работ по оценке эффективности НХТ на основании динамики показателей жесткости первичной опухоли с помощью соноэластографии (СЭГ), и лишь 2 из них посвящены исследованию компрессионной эластогра-фии [20,21], в остальных применялась эластография сдвиговой волны [22][23][24][25][26]. M. Hayashi и соавт.…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Correlation of the value of sonoelastography strain ratio with the degree of pathological regression in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy

Бусько¹,

Мищенко²,

Semiglazov³

et al. 2016

Tumors of female reproductive system

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ОПУХОЛИ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ TUMORS OF FEMALE REPRODUCTIVE SYSTEM Диагностика Оригинальные статьиВведение Неоадъювантная (предоперационная) химиотера-пия (НХТ) является одним из важнейших компонен-тов комплексного лечения местно-распространенного рака молочной железы (РМЖ) (стадии IIb-IIIb, с). В настоящее время неоадъювантное лечение исполь-зуется не только при неоперабельных или условно операбельных опухолях, но и в случае операбельного процесса -как в целях увеличения числа органосох-раняющих операций, так и для определения чувстви-тельности к системным видам терапии. Объективная оценка изменения размера первичной опухоли и ста-туса регионарных лимфатических узлов в процессе предоперационной системной терапии является не-отъемлемой частью лечения больных РМЖ. Возмож-ность прогнозирования патоморфологического ответа опухолевой ткани с использованием лучевых методов диагностики на ранних этапах системной терапии позволяет своевременно изменить тактику лечения при отсутствии эффекта, а также определить канди-датов для органосохраняющего лечения. Положи-тельный ответ на НХТ позволяет не только сохранить молочную железу, но и уменьшить объем подмышеч-ной диссекции (за счет выполнения биопсии сигналь-ных лимфатических узлов). Кроме того, у пациенток, достигших полного патоморфологического регресса (рCR), уменьшается объем послеоперационной лу-чевой терапии [1][2][3][4]. Многочисленные клинические исследования показали, что в тех случаях, когда удава-лось достичь рСR после НХТ, наблюдалось существен-ное улучшение показателей общей и безрецидивной выживаемости пациенток [5][6][7]. Наиболее хорошо эта

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Early Evaluation of Relative Changes in Tumor Stiffness by Shear Wave Elastography Predicts the Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer

Abstract: Early evaluation of relative changes in tumor stiffness using SWE could effectively predict the response to neoadjuvant chemotherapy in patients with breast cancer and might indicate better therapeutic strategies on a timelier basis.

Cited by 57 publications

References 31 publications

Multiple‐point magnetic resonance acoustic radiation force imaging

Multiple‐point magnetic resonance acoustic radiation force imaging

Evaluation of the Laser-Induced Thermotherapy Treatment Effect of Breast Cancer Based on Tissue Viscoelastic Properties

Correlation of the value of sonoelastography strain ratio with the degree of pathological regression in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy

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