Early Experience With Combined Use of Two Plant-Based Hemostatic Agents

Matsushita, T.; Masuda, Shinsuke; Inoue, Tomoya

doi:10.1016/j.athoracsur.2009.08.067

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Viscosity can also be defined by molecular forces, such as surface fluid friction, which induces resistance to fluid flow. Viscosity is a crucial property used to describe the flow characteristics of hemostatic agents when applied to the site of a skin wound, and a certain level of viscosity is an essential factor in the gel’s ability to adhere to the skin and inhibits the release of blood [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Shin,

Hillyer,

Shin

2024

Gels

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Bleeding resulting from surgical procedures or trauma, including gunshot wounds, represents a life-threatening health issue. Therefore, the development of safe, effective, and convenient hemostatic agents is critical in securing the “golden time” to save patients’ lives. Plant-derived compounds and plant extracts have been regarded as promising sources of hemostatic agents in previous studies, regulating hemostatic function with low toxicity and minimal side effects within the human body. Aloe vera-based hydrogels, which are characterized by flexible strength and high functionality, have emerged as a promising platform for wound applications due to their unique biocompatibility features. This study provides a comprehensive exploration of the utilization of thickening agents and natural agents such as xanthan gum, carrageenan, Carbomer, and alginate in applying aloe vera-based hydrogels as a hemostatic. Furthermore, it also tests the use of aloe vera-based hydrogels for therapeutic delivery at wound sites through the incorporation of various antimicrobial agents to extend the utility of the hydrogels beyond hemostasis. Our novel applied research utilizes aloe vera-based hydrogel as an antimicrobial hemostatic agent, providing valuable insights for a wide range of applications and highlighting its potential to enhance hemorrhage control in various emergency scenarios.

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Section: Resultsmentioning

confidence: 99%

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Shin,

Hillyer,

Shin

2024

Gels

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“…The efficacy of MPH may be increased by the addition of a fibrinolytic inhibitor such as tranexamic acid or crystallized calcium ions to the MPH powder because physiological coagulation requires the presence of calcium [2]. Matsushita, et al reported a unique and novel hemostatic combination with two plant-based hemostatic agents using MPH and oxidized regenerated cellulose [18].…”

Section: Discussionmentioning

confidence: 99%

“…The hemostatic effects of MPH have been demonstrated under various experimental settings [7][8][9][10][11][12][13]. Although the clinical effects of MPH have been reported in other fields such as neurosurgery, the clinical effects of MPH in cardiovascular surgery is unclear [14][15][16][17][18]. Therefore, the initial clinical efficacy of the hemostatic agent, MPH, in PVS was herein investigated.…”

Section: Introductionmentioning

confidence: 99%

Initial Clinical Efficacy and Safety of Microporous Polysaccharide Hemospheres (MPH) for Needle-Hole Bleeding from Expanded Polytetrafluoroethylene Grafts in Peripheral Vascular Surgery

Furukawa¹

2016

Vasc Med Surg

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Background: In this retrospective study, the initial clinical effects of microporous polysaccharide hemospheres (MPH) in peripheral vascular surgery were investigated. Methods: Forty patients who underwent peripheral vascular surgery using expanded polytetrafluoroethylene (ePTFE) grafts were included. Between May 2008 and June 2012, 26 patients (group A) were administered MPH (Arista AH ®) 1 g, while 14 (group B) were treated with fibrin sealant (Beriplast P ®) 1 ml at anastomosis between the prosthesis and native vessel during surgery. Perioperative results and complications including early graft patency, wound problems and postoperative general co-morbidities were retrospectively evaluated in both groups. Results: The numbers of anastomoses between native vessels and ePTFE grafts were 2.2 ± 0.5 in group A and 2.6 ± 1.2 in group B (p=0.14). The mean amount of intraprocedural blood loss was significantly lower in group A: 28.8 ± 24.5 ml than in group B: 88.2 ± 93.7 ml (p<0.01). The patencies of ePTFE grafts in the acute phase were 96.2% in group A and 85.7% in group B (p=0.24). Conclusion: The results of the present study indicated that MPH contributed to acceptable and similar early clinical and surgical outcomes with safety and efficacy for hemostasis to those of fibrin sealant during peripheral vascular surgery using ePTFE grafts.

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“…Например, эффективный гемостатический препарат местного дей-ствия поликапран представляет собой ОЦ с включением ε-аминокапроновой кислоты как ингибитора фибрино-лиза [2]. Кроме того, ОЦ комбинируют с другими гемоста-тическими средствами для успешного достижения гемо-стаза при различных операциях [29].…”

Section: методы борьбы с локальным кровотечением и их роль в возникноunclassified