Early goal-directed therapy for severe sepsis and septic shock: A living systematic review

Simpson, Steven Q.; Gaines, Melissa; Hussein, Youness; Badgett, Robert G.

doi:10.1016/j.jcrc.2016.06.017

Cited by 42 publications

(23 citation statements)

References 24 publications

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“…Two other meta-analyses of the 647 patients who were enrolled in these trials demonstrate moderate evidence for reduction in mortality when an early lactate clearance strategy was used, compared with either usual care (nonspecified) or with a ScvO2 normalization strategy [38,39].…”

Section: We Suggest Guiding Resuscitation To Normalize Lactate In Patmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Rhodes

Evans

Alhazzani

et al. 2017

Critical Care Medicine

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2,383

814

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Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.

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Section: We Suggest Guiding Resuscitation To Normalize Lactate In Patmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Rhodes

Evans

Alhazzani

et al. 2017

Critical Care Medicine

Self Cite

2,383

814

View full text Add to dashboard Cite

show abstract

“…Serum lactate is a component of many resuscitative algorithms including the Surviving Sepsis Campaign and the sepsis3 pathways as described by the Society of Critical Care Medicine 1–3. The optimal frequency in which to follow serum lactate is unclear.…”

Section: Discussionmentioning

confidence: 99%

Contemporary hemodynamic monitoring, fluid responsiveness, volume optimization, and endpoints of resuscitation: an AAST critical care committee clinical consensus

Martin

Codner

Greene

et al. 2020

Trauma Surg Acute Care Open

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This article, on hemodynamic monitoring, fluid responsiveness, volume assessment, and endpoints of resuscitation, is part of a compendium of guidelines provided by the AAST (American Association for the Surgery of Trauma) critical care committee. The intention of these guidelines is to inform practitioners with practical clinical guidance. To do this effectively and contemporarily, expert consensus via the critical care committee was obtained. Strict guideline methodology such a GRADE (Grading of Recommendations Assessment, Development and Evaluation) was purposefully NOT used so as not to limit the possible clinical guidance. The critical care committee foresees this methodology as practically valuable to the bedside clinician.

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“…Elevated lactate levels are associated with worse outcomes among patients with sepsis (125), stimulating interest in lactate clearance as a resuscitation marker. Guidelines for the care of septic patients recommend normalization of lactate levels during sepsis treatment (126), although the benefit of lactate-guided resuscitation strategies remains unclear (127,128).…”

Section: Metabolic Programming During Tissue Damage and Repairmentioning

confidence: 99%

Immunometabolism of pro-repair cells

Singer¹,

Chandel²

2019

Journal of Clinical Investigation

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Early goal-directed therapy for severe sepsis and septic shock: A living systematic review

Cited by 42 publications

References 24 publications

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Contemporary hemodynamic monitoring, fluid responsiveness, volume optimization, and endpoints of resuscitation: an AAST critical care committee clinical consensus

Immunometabolism of pro-repair cells

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