Early life lessons: The lasting effects of germline epigenetic information on organismal development

Galan, Carolina; Krykbaeva, Marina; Rando, Oliver J.

doi:10.1016/j.molmet.2019.12.004

Cited by 27 publications

(10 citation statements)

References 112 publications

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“…In the last years, there has been special interest in the characterization of epigenetic mechanisms during spermatogenesis that control the reprogramming of the paternal genome, due to the possible trans-generational transmission of acquired traits (Lacal and Ventura, 2018;Galan et al, 2019). Epigenetic reprogramming involves histones post-translational modifications (PTMs), DNA methylation, and changes in small non-coding RNAs that modulate gene expression in response to basal transcriptional programs and environmental signals (Jenkins and Carrell, 2012).…”

Section: Introductionmentioning

confidence: 99%

Dopamine Receptor D1 Contributes to Cocaine Epigenetic Reprogramming of Histone Modifications in Male Germ Cells

González

Gancedo

Garazatua

et al. 2020

Front. Cell Dev. Biol.

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Paternal environmental perturbations, including cocaine intake, can affect the development and behavior of the offspring through epigenetic inheritance. However, the mechanism by which cocaine alters the male germ cells epigenome is almost unexplored. Here, we report that cocaine-treated male mice showed alterations on specific histone post-translational modifications (PTMs) including increased silent chromatin marks H3K9me3 and H3K27me3 and decreased active enhancer and promoter marks H3K27ac and H3K4me3 in isolated germ cells. Also, cocaine increased H3K9ac and H4K16ac levels, involved in the replacement of histones by protamines that take place at round spermatid stage. Cocaine also altered histones H3/H4 epigenetic enzymes by increasing acetyltransferase KAT8/MOF, deacetylase SIRT1 and methyltransferase KMT1C/G9A, and decreasing deacetylases HDAC1/2 and demethylase KDM1A/LSD1 protein levels. Moreover, a pre-treatment with dopamine receptor 1 (DRD1) antagonist SCH23390 (SCH) blocked cocaine effects on H3K4me3, H3K27me3, and H4K16ac epigenetic marks. Interestingly, treatment with SCH-only was able to modify most of the histone marks tested here, pointing to a dopamine role in controlling histone PTMs in germ cells. Taken together, our data suggest a key role for DRD1 in mediating cocaine-triggered epigenetic modifications related to the silencing of gene transcription and the histone-to-protamine replacement that controls chromatin architecture of maturing sperm cells, and pinpoints a novel role of the dopaminergic system in the regulation of male germ cells reprogramming.

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Section: Introductionmentioning

confidence: 99%

Dopamine Receptor D1 Contributes to Cocaine Epigenetic Reprogramming of Histone Modifications in Male Germ Cells

González

Gancedo

Garazatua

et al. 2020

Front. Cell Dev. Biol.

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“…There is growing evidence of the impact of adversity in early life or environmental stimulus on offspring where the contribution of epigenetic alterations in memory formation has been described [ 8 , 138 , 139 , 140 ]. One of the best-understood models in this field is the nematode C. elegans .…”

Section: Evidence In Model Organisms: From One Generation To the Next Generationsmentioning

confidence: 99%

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease

2021

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During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer’s disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.

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“…There is growing evidence of the impact of adversity in early life or environmental stimulus on offspring where the contribution of epigenetic alterations in memory formation has been described [8,[133][134][135]. One of the best-understood models in this field is the nematode C. elegans.…”

Section: Evidence In Model Organisms: From One Generation To the Next Generationsmentioning

confidence: 99%

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease

Bellver-Sanchis¹,

Pallàs²,

Griñán-Ferré³

2021

Preprint

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During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer’s diseases (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the eatiology. So, how can these changes be transmitted from one gen-eration to the next? Answering this question would allow us to understand how the environ-ment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the under-standing of the relevance of heritability in neurodegenerative diseases. In fact, we highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory, to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. And ends, we summarize evidence of how epigenetic marks inherited by experi-ence and/or environmental stimuli contribute to cognitive status offspring, since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.

show abstract

Early life lessons: The lasting effects of germline epigenetic information on organismal development

Cited by 27 publications

References 112 publications

Dopamine Receptor D1 Contributes to Cocaine Epigenetic Reprogramming of Histone Modifications in Male Germ Cells

Dopamine Receptor D1 Contributes to Cocaine Epigenetic Reprogramming of Histone Modifications in Male Germ Cells

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease

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