Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice

Guérin, Delphine; Sacquet, Joëlle; Mandairon, Nathalie; Jourdan, F; Didier, Anne

doi:10.1016/j.neurobiolaging.2007.05.020

Cited by 76 publications

(59 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dense SOM innervation observed in both human and rodent OB peduncle supports the notion that external SOM sources compensate the imbalance between peptide and receptors levels in the OB. This would then suggest a role for SOM in centrifugal feedback mechanisms, as recently described for other neuromodulatory molecules (Brunjes et al, 2014;Guérin et al, 2009).…”

Section: Discussionsupporting

confidence: 56%

“…By functional magnetic resonance imaging, OB and olfactory nerve atrophy is already measurable in mild cognitive impairment subjects and highly correlated with cognitive deficits (Thomann et al, 2009;Wang et al, 2010). Surprisingly given the recognized link between neocortical tau burden and cognitive impairment severity (Nelson et al, 2012), experimental studies directly relating tau hyperphosphorylation status in the olfactory system with olfactory dysfunction are rare in the literature (Cassano et al, 2011;Phillips et al, 2011), as compared with the documented studies of olfactory deficits in APP genetic models (see Guérin et al, 2009;Montgomery et al, 2011;Wesson et al, 2010aWesson et al, , 2011Wu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice

Martel

Simon

Nocera

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice

Martel

Simon

Nocera

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

“…Other published studies have suggested that with a very similar experimental design, the system is capable of assessing the affect of pathological aging on olfactory performance (Guerin et al, 2009). In this paper, we were able to characterize some discrete olfactory memory deficits in young Tg2576 mice, a model for Alzheimer's disease.…”

Section: Discussionmentioning

confidence: 81%

A computer-assisted odorized hole-board for testing olfactory perception in mice

Mandairon

Sultan

Rey

et al. 2009

Journal of Neuroscience Methods

Self Cite

View full text Add to dashboard Cite

“…LC degeneration increased olfactory deficits in APP/PS1 transgenic mice (Rey et al 2012). Further, during the early pathological process in the transgenic Tg2576 mice, LC degeneration promoted olfactory dysfunction (Guérin et al 2009). …”

Section: Locus Coeruleus Pathology In Admentioning

confidence: 94%

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Daulatzai

2016

Neurotox Res

View full text Add to dashboard Cite

Sporadic Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is essential to unravel its etiology and pathogenesis. This should enable us to study the presymptomatic stages of the disease and to analyze and reverse the antemortem behavioral, memory, and cognitive dysfunction. Prima facie, an ongoing chronic vulnerability involving neural insult may lead normal elderly to mild cognitive impairment (MCI) and then to AD. Development of effective preventive and therapeutic strategies to thwart the disease pathology obviously requires a thorough delineation of underlying disruptive neuropathological processes. Our sensory capacity for touch, smell, taste, hearing, and vision declines with advancing age. Declines in different sensory attributes are considered here to be the primary "first-tier pathologies." Olfactory loss is among the first clinical signs of neurodegenerative diseases including AD and Parkinson's disease (PD). Sensory dysfunction in the aged promotes pathological disturbances in the locus coeruleus, basal forebrain, entorhinal cortex, hippocampus, and several key areas of neocortex and brainstem. Hence, sensory dysfunction is the pivotal factor that may upregulate cognitive and memory dysfunction. The age-related constellation of comorbid pathological factors may include apolipoprotein E (APOE) genotype, obesity, diabetes, hypertension, alcohol abuse, head trauma, and obstructive sleep apnea. The concepts and trajectories delineated here are the dynamic pillars of the current hypothesis presented-it postulates that the sensory decline, in conjunction with the above pathologies, is crucial in triggering neurodegeneration and promoting cognitive/memory dysfunction in aging and AD. The application of this thesis can be important in formulating new multifactorial preventive and treatment strategies (suggested here) in order to attenuate cognitive and memory decline and ameliorate pathological dysfunction in aging, MCI, and AD.

show abstract

Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice

Cited by 76 publications

References 56 publications

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice

A computer-assisted odorized hole-board for testing olfactory perception in mice

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Contact Info

Product

Resources

About