Early markers of gestational diabetes mellitus

Omazić, Jelena; Viljetić, Barbara; Ivić, Vedrana; Kadivnik, Mirta; Zibar, Lada; Müller, Andrijana; Wagner, Jasenka

doi:10.11613/bm.2021.030502

Cited by 18 publications

(9 citation statements)

References 93 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They have identified a substantial difference between the two groups. [21] Consistent with our findings and supported by worldwide literature, earlier research has focused chiefly on the intricate connection between serum visfatin and Type 2 Diabetes Mellitus; however, attention has recently shifted to GDM in obese women.…”

Section: Discussionsupporting

confidence: 92%

Visfatin as a Biomarker for Early Detection of Gestational Diabetes Mellitus

Ruidar¹,

Mushtaq²,

Raza³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Objective: The current study aims to determine whether an increase in visfatin level resulted in Gestational Diabetes Mellitus (GDM) in pregnant females. Study Design: Retrospective Study Place and Duration: Department of Medicine, Dr. Ziauddin Hospital, North Nazimabad, Karachi, From November 2021 to April 2022. Methods: In this study, 83 pregnant females aged 18-46 years were inducated. After obtaining informed written consent, detailed demographic data were recorded. Gestational age and gravidity among all females were recorded. Previous history and frequency of GDM were assessed. Blood samples were taken to determine the concentration of visfatin and glucose levels. SPSS 24.0 was used to analyze all data. Results: In this study, the mean age was 29.11±8.42 years, and the mean BMI was 26.2±3.32 kg/m2. The mean gestational age was 34.11±4.33 weeks. Most of the cases were from rural areas and had poor socio-economic status. We found that 44 (53.01%) subjects had gestational diabetes mellitus while 39 (46.9%) had no diabetes. The visfatin level in patients with gestational diabetes was higher, 4.2±7.124, compared to non-diabetes cases, 1.4±1.432, with a p-value<0.003. Conclusion: Ultimately, we determined that visfatin levels were considerably elevated in gestational diabetes mellitus beginning in the first trimester of pregnancy. An innovative biomarker for GDM detection is increased visfatin levels during pregnancy. Keywords: Visfatin, Gestational Diabetes, Pregnant Females

show abstract

Section: Discussionsupporting

confidence: 92%

Visfatin as a Biomarker for Early Detection of Gestational Diabetes Mellitus

Ruidar¹,

Mushtaq²,

Raza³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…Some early biomarkers of GDM, such as plasma C-peptide, fibroblast growth factor 21 and fatty acid binding protein 4, have also been reported but are not suitable for early GDM diagnosis. 15 According to the analysis in our study, some changes in plasma proteins occurred before 20 weeks of GA, involving proteasome activation, pancreatic secretion, fatty acid degradation, and apoptotic pathways, indicating the feasibility of early GDM detection by protein markers rather than OGTTs.…”

Section: Discussionsupporting

confidence: 51%

Early Gestational Blood Markers to Predict Preeclampsia Complicating Gestational Diabetes Mellitus

Xie¹,

Zhou²,

Tao³

et al. 2023

DMSO

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications that share some common risk factors. GDM patients are also at high risk for PE. There are no sensitive markers for prediction, especially for the occurrence of PE in GDM patients. This study investigated plasma proteins for the prediction of PE in GDM patients. Methods: A total of 10 PE, 10 GDM, and 5 PE complicated with GDM cases, as well as 10 pregnant controls without obvious complications, were included in the nested cohort. The proteomics in the plasma collected at 12-20 weeks of gestational age (GA) were analyzed by liquid chromatography-mass spectrometry/mass spectrometry. Some potential markers, such as soluble transferrin receptor (sTfR), ceruloplasmin (CP), apolipoprotein E (ApoE) and inositol 1,4,5-trisphosphate receptor 1 (ITPR1), were validated using enzyme-linked immunosorbent assays. Results: Functional analysis of the plasma showed that proteasome activation, pancreatic secretion, and fatty acid degradation were activated in the GDM group, and renin secretion-, lysosome-, and proteasome pathways involving iron transport and lipid metabolism were enriched in the PE group, distinguishing PE complicating GDM. Conclusion: Through proteomics analysis of plasma in early pregnancy, PE complicating GDM may have a unique mechanism from that of PE alone. Plasma sTfR, CP and ApoE levels have potential clinical applications in early screening.

show abstract

“…Multiple biochemical markers have been studied to predict the occurrence of GDM and PE, and CRP, TNF-α, IL-6, and B-type natriuretic peptides are common predictive markers ( 183 , 184 ), but none are used as practical clinical markers. Serum sFlt1 / placental growth factor (PlGF) is a valid marker for predicting and diagnosing PE ( 185 ).…”

Section: Mechanism and Predictive Markersmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors and pathophysiological changes. Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM, but whether GDM is independently related to the occurrence of PE has remained controversial. GDM complicated by PE further increases perinatal adverse events with greater impact on the future maternal and offspring health. Identify factors associated with PE in women with GDM women, specifically those that are controllable, is important for improving pregnancy outcomes. This paper provides the findings of a review on the correlation between GDM and PE, factors associated with PE in women with GDM, possible mechanisms, and predictive markers. Most studies concluded that GDM is independently associated with PE in singleton pregnancy, and optimizing the treatment and management of GDM can reduce the incidence of PE, which is very helpful to improve pregnancy outcomes.

show abstract

Early markers of gestational diabetes mellitus

Cited by 18 publications

References 93 publications

Visfatin as a Biomarker for Early Detection of Gestational Diabetes Mellitus

Visfatin as a Biomarker for Early Detection of Gestational Diabetes Mellitus

Early Gestational Blood Markers to Predict Preeclampsia Complicating Gestational Diabetes Mellitus

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Contact Info

Product

Resources

About