Early melanoma invasivity correlates with gut fungal and bacterial profiles

Vitali, Francesco; Colucci, Roberta; Paola, Monica Di; Pindo, Massimo; Filippo, Carlotta De; Moretti, Samuele; Cavalieri, Duccio

doi:10.1111/bjd.20626

Cited by 33 publications

(40 citation statements)

References 46 publications

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“…The composition of the gut microbiome is associated with the prognosis and evolution of advanced melanoma and is considered a biomarker for immune checkpoint therapy ( Gopalakrishnan et al, 2018 ; Mohiuddin et al, 2021 ). Recently, the intestinal fungal composition of melanoma patients was investigated for the first time by Vitali et al (2021) . They found significantly higher fungal richness in melanoma patients, and Saccharomycetales sp.…”

Section: Gut Mycobiota and Non-gastrointestinal Neoplasmsmentioning

confidence: 99%

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Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

et al. 2022

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Numerous studies have demonstrated the importance of gut bacteria in the development of malignancy, while relatively little research has been done on gut mycobiota. As a part of the gut microbiome, the percentage of gut mycobiota is negligible compared to gut bacteria. However, the effect of gut fungi on human health and disease is significant. This review systematically summarizes the research progress on mycobiota, especially gut fungi, in patients with head and neck cancer (HNC), esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), pancreatic cancer, melanoma, breast cancer, and lung carcinoma-induced cachexia. Moreover, we also describe, for the first time in detail, the role of the fungal recognition receptors, C-type lectin receptors (CLRs) (Dectin-1, Dectin-2, Dectin-3, and Mincle) and their downstream effector caspase recruitment domain-containing protein 9 (CARD9), in tumors to provide a reference for further research on intestinal fungi in the diagnosis and treatment of malignant tumors.

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Section: Gut Mycobiota and Non-gastrointestinal Neoplasmsmentioning

confidence: 99%

“…Moreover, Malasseziales sp. and Malassezia globosa were significantly enriched in invasive melanoma compared to in situ melanoma ( Vitali et al, 2021 ). Further research also found that the gut fungal profile may be relevant to melanoma regression.…”

Section: Gut Mycobiota and Non-gastrointestinal Neoplasmsmentioning

confidence: 99%

Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

et al. 2022

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“…Vitali et al characterized the gut fungal community in addition to the bacterial community in skin cancer patients [ 99 ]. In 20 subjects diagnosed with melanoma, the α-diversity of the fungal community revealed significantly higher richness in melanoma patients compared to healthy individuals and showed that the order Saccharomycetales was enriched in melanoma patients.…”

Section: Diagnostic Implications Of the Mycobiome In Cancer Patientsmentioning

confidence: 99%

The Mycobiome: Cancer Pathogenesis, Diagnosis, and Therapy

Gamal

Elshaer

Alabdely

et al. 2022

Cancers

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Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various levels, including cancer pathogenesis, diagnosis and prognosis, and treatment. Since most studies have focused only on the role of bacteria in this process, in this article we review the role of fungi—another important group of the microbiome, the totality of which is referred to as the “mycobiome”—in the development of cancer and how it can impact responses to anticancer medications. Furthermore, we provide recent evidence that shows how the different microbial communities interact and affect each other at gastrointestinal and non-gastrointestinal sites, including the skin, thereby emphasizing the importance of investigating the microbiome beyond bacteria.

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“…Vitali et al found evidence potentially implicating gut microbiota in the pathogenesis of melanoma. The authors have shown that the composition of gut microbiota in early‐stage melanoma changes from in situ to invasive and then to metastatic melanoma 12 . The authors also found the gut bacterial and fungal profile to be significantly different in melanoma patients compared to controls; the microbiota of melanoma patients demonstrated an abundance of yeasts belonging to the order of Saccharomytecales and Prevotella copri species 12 …”

Section: Microbiome As a Risk Factor For Melanomamentioning

confidence: 99%

The gut microbiome and melanoma: A review

Makaranka

Scutt

Frixou

et al. 2022

Experimental Dermatology

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Disturbances in the microbial ecosystem have been implemented in chronic inflammation, immune evasion and carcinogenesis, with certain microbes associated with the development of specific cancers. In recent times, the gut microbiome has been recognised as a potential novel player in the pathogenesis and treatment of malignant melanoma. It has been shown that the composition of gut microbiota in early‐stage melanoma changes from in situ to invasive and then to metastatic disease. The gut bacterial and fungal profile has also been found to be significantly different in melanoma patients compared to controls. Multiple studies of immune checkpoint inhibitor (ICI) therapies have shown that the commensal microbiota may have an impact on anti‐tumor immunity and therefore ICI response in cancer patients. When it comes to chemotherapy and radiotherapy treatments, studies demonstrate that gut microbiota are invaluable in the repair of radiation and chemotherapy‐induced damage and therapeutic manipulation of gut microbiota can be an effective strategy to deal with side effects. Studies demonstrate the oncogenic and tumor‐suppressive properties of the gut microbiome, which may play a role in the pathogenesis of melanoma. Despite this, investigations into specific interactions are still in its infancy, but starting to gain momentum as more significant and clinically relevant effects are emerging.

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Early melanoma invasivity correlates with gut fungal and bacterial profiles

Cited by 33 publications

References 46 publications

Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

The Mycobiome: Cancer Pathogenesis, Diagnosis, and Therapy

The gut microbiome and melanoma: A review

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