Early morning bright light phase advances the human circadian pacemaker within one day

Burešová, M.; Dvořáková, M; Zvolský, P; Illnerová, Helena

doi:10.1016/0304-3940(91)90646-b

Cited by 58 publications

(20 citation statements)

References 18 publications

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“…For example, bright light exposure (3000 lux) in the early morning (03:00-09:00) within one day resulted in a phase advance of DLMO (Buresova et al, 1991). Our present findings also showed a significant advance of DLMO on exposure to bright light (Ͼ3000 lux).…”

Section: Discussionsupporting

confidence: 77%

Effects of Different Light Intensities in the Morning on Dim Light Melatonin Onset

Kozaki

Toda

Noguchi

et al. 2011

J Physiol Anthropol

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Section: Discussionsupporting

confidence: 77%

Effects of Different Light Intensities in the Morning on Dim Light Melatonin Onset

Kozaki

Toda

Noguchi

et al. 2011

J Physiol Anthropol

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“…It is possible that had we measured the entire melatonin profile, we may have found larger phase advances in the offset of the melatonin rhythm (DLMOff), as this phase marker can show larger phase advances than the DLMO, in response to morning light (Buresova et al, 1991). In any case, a key determinant of the speed and direction of reentrainment is the amount and timing of light exposure on arrival.…”

Section: Discussionmentioning

confidence: 99%

Preflight Adjustment to Eastward Travel:3 Days of Advancing Sleep with and without Morning Bright Light

et al. 2003

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Jet lag is caused by a misalignment between circadian rhythms and local destination time. As humans typically take longer to re-entrain after a phase advance than a phase delay, eastward travel is often more difficult than westward travel. Previous strategies to reduce jet lag have focused on shaping the perceived light-dark cycle after arrival, in order to facilitate a phase shift in the appropriate direction. Here we tested treatments that travelers could use to phase advance their circadian rhythms prior to eastward flight. Thus, travelers would arrive with their circadian rhythms already partially re-entrained to local time. We determined how far the circadian rhythms phase advanced, and the associated side effects related to sleep and mood.

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“…Artificial bright light is able to entrain the MLT secretion: in subjects lighted with 3,000 lx between 03:00 and 09:00 h, a phase advance is observed [22]. Conversely, a phase delay is observed after evening administration of the light area.…”

Section: Plasma Mlt a Probe Of The Circadian Clockmentioning

confidence: 99%

The Physiology and Pharmacology of Melatonin in Humans

Geoffriau¹,

Brun²,

Carrault³

et al. 1998

Horm Res Paediatr

112

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Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or entrain MLT production on light schedule. The nyctohemeral rhythm of this hormone can be determined by repeated measurement of plasma or saliva MLT or urine sulfatoxy-MLT, the main hepatic metabolite. MLT can be considered as the output (the hand) of the endogenous clock. Since the regulating system follows a central and sympathetic nervous pathway, an abnormality at any level could unspecifically modify the MLT secretion, especially in patients with sympathalgia or dysautonomia. MLT plays the role of an endogenous zeitgeber on core temperature or sleep-wake cycle. Exogenous MLT is able to influence the endogenous secretion of the hormone according to a phase-response curve. There are practical implications for this property in situations when biological rhythms are disturbed (jet-lag syndrome, delayed sleep phase syndrome, insomnia in blind people, shift-work, insomnia in elderly people). Improvement of pharmaceutical forms (controlled release preparations) or development of MLT analogs could lead to decisive progress.

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Early morning bright light phase advances the human circadian pacemaker within one day

Cited by 58 publications

References 18 publications

Effects of Different Light Intensities in the Morning on Dim Light Melatonin Onset

Effects of Different Light Intensities in the Morning on Dim Light Melatonin Onset

Preflight Adjustment to Eastward Travel:3 Days of Advancing Sleep with and without Morning Bright Light

The Physiology and Pharmacology of Melatonin in Humans

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