Early Myocardial Functional Alterations in Patients with Obstructive Sleep Apnea Syndrome

Kepez, Alper; Niksarlıoğlu, Elif Yelda; Hazırolan, Tuncay; Ranci, Ortenca; Kabul, Hasan Kutsi; Demir, Ahmet Uğur; Kaya, Ergün Barış; Kocabaş, Uğur; Aytemir, Kudret; Şahin, Altan; Tokgözoğlu, Lâle; Nazli, Nasıh

doi:10.1111/j.1540-8175.2008.00809.x

Cited by 36 publications

(36 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are consistent with a previous large cross-sectional study by Niroumand et al, who found no significant difference in the E/A ratio between OSAS and non-OSAS patients [15]. However, in several other studies, associations were reported between OSAS severity and E/A ratio [35,36], A peak wave [36] or LA volume [37], with reversibility after a few months of CPAP treatment [33,37,38]. Furthermore, AHI was significantly correlated Left ventricular diastolic function in obstructive sleep apnoea syndrome 9 with LAA, which is a surrogate for diastolic function.…”

Section: Left Ventricular Diastolic Functionsupporting

confidence: 94%

Left ventricular diastolic dysfunction in obstructive sleep apnoea syndrome by an echocardiographic standardized approach: An observational study

Bodez

Lang

Meuleman

et al. 2015

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

show abstract

Section: Left Ventricular Diastolic Functionsupporting

confidence: 94%

Left ventricular diastolic dysfunction in obstructive sleep apnoea syndrome by an echocardiographic standardized approach: An observational study

Bodez

Lang

Meuleman

et al. 2015

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

show abstract

“…LV systolic longutidinal dysfunctions of myocardium can be evaluated quantitatively by TDI method. Previous TDI studies have showed that OSA accompanied by sleep-induced LV systolic longutidinal dysfunction (34)(35)(36). TDI is more sensitive than EF in the detection of subtle changes in the LV contractile function.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study

Altekin¹,

Yanıkoğlu²,

Karakaş³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: We aimed to evaluate the subclinical left ventricular (LV) systolic dysfunction with the automated function imaging method (AFI) based on speckle tracking echocardiography (STE) in obstructive sleep apnea patients (OSA) with normal left ventricular ejection fraction (LVEF) and without any confounding disease that can cause myocardial dysfunction. Methods: Twenty-one healthy individuals and 58 OSA patients were included in this observational cross-sectional study. According to the severity of disease, OSA patients were examined in three groups; mild, moderate and severe OSA. Apical 2-, 3-and 4-chamber images were obtained for AFI evaluation. The global systolic longitudinal strain (GL S ) values were determined for each view, and averages of these were used in comparison of the patient groups. One-way ANOVA, Kruskal-Wallis, Pearson correlation tests and linear regression analysis were used for statistical analysis. Results: The GL S values of the OSA patients were lower than of the healthy individuals and these values were decreased along with the OSA severity (Healthy:-25.58±-2.16%, Mild:-23.93±-3.96%, Moderate:-21.27±-2.60%, Severe:-16.94±-2.66%, respectively). The difference was significant between moderate OSA patients and healthy individuals, and significant between severe OSA patients and all other groups (p<0.03). The apnea-hypopnea index was found to be correlated with the GL S (β=-0.659, 95% CI: 0.09-0.17, p<0.001). Conclusion: Longitudinal LV mechanics in OSA patients with normal LVEF are deteriorated in the subclinical stage being associated with the severity of disease. AFI can be used as an effective and safe method in the determination of subclinical myocardial dysfunction in OSA patients, because it is semi-automated and easy to use with a short analysis time.(Anadolu Kardiyol Derg 2012; 12: 320-30) Key words: Obstructive sleep apnea, speckle tracking echocardiography, myocardial strain, regression analysis 320 ÖZET Amaç: Sol ventrikül ejeksiyon fraksiyonu normal ve miyokart fonksiyonlarını etkileyecek ek hastalığı bulunmayan, obstrüktif uyku apneli (OUA) hastalarda, subklinik sol ventrikül sistolik disfonksiyonunu, iki boyutlu benek izleme ekokardiyografi tekniğine dayanan, otomatik fonksiyonel görün-tüleme yöntemi (OFG) ile değerlendirmeyi amaçladık. Yöntemler: Gözlemsel enine-kesitli çalışmamıza 21'i sağlıklı, 58'i OUA hastası olan toplam 79 kişi alındı. OUA'lı hastalar hastalığın ciddiyetine göre hafif, orta ve ağır olarak 3 gruba ayrıldı. OFG değerlendirmesi için sol ventrikülün apikal 2-, 3-, 4-boşluk görüntüleri kullanıldı. İlgili boşluk-lara ait sistolik longitüdinal deformasyon değerlerinin aritmetik ortalaması olan, global longitüdinal deformasyon değerleri gruplar arasında karşılaştırıldı. İstatistiksel analiz için tek -yönlü ANOVA, Kruskal-Wallis, Pearson korelasyon testleri ve doğrusal regresyon analizi kullanıldı. Bulgular: Sağlıklı gruba göre hafif OUA grubundan itibaren hastalığın ciddiyeti ile global longitüdinal deformasyon değerleri azalmaktaydı (Sağlıklı: -%25...

show abstract

“…Furthermore, several studies have shown various impaired LV diastolic function markers in patients with OSAS compared with in controls: enlarged left atrial size [46,[78][79][80], prolonged isovolumic relaxation time (IVRT) [46,57,78,81], altered E/A ratio [46,78,79,[81][82][83][84], lower early diastolic mitral annular velocity (e ) [79,82,83,85,86] and increased E/e ratio [43,78,87] (Fig. 3).…”

Section: Diastolic Dysfunction In Osasmentioning

confidence: 96%

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

Bodez

Damy

Soulat-Dufour³

et al. 2016

Archives of Cardiovascular Diseases

View full text Add to dashboard Cite

Obstructive sleep apnoea syndrome (OSAS) is a frequent sleep disorder that is known to be an independent risk factor for arterial hypertension (AHT). Potential confounding factors associated with both OSAS and AHT, such as age, diabetes mellitus and obesity, have been explored extensively, and are considered as independent but additive factors. However, these factors are also contributors to left ventricular (LV) hypertrophy (LVH) and LV diastolic dysfunction, both of which are important causes of cardiovascular morbidity, and have been reported to be associated with OSAS for decades. In this review, we present an overview of how OSAS may promote changes in LV geometry and diastolic dysfunction through its best-known cardiovascular complication, arterial hypertension. We also summarize the epidemiological links between OSAS and LVH, outline diastolic dysfunction in OSAS patients, and try to highlight the mechanisms responsible, focusing on the effect of confounding factors.

show abstract

Early Myocardial Functional Alterations in Patients with Obstructive Sleep Apnea Syndrome

Abstract: Patients with OSAS display a regional pattern of right ventricular dysfunction correlated with the severity of disease.

Cited by 36 publications

References 21 publications

Left ventricular diastolic dysfunction in obstructive sleep apnoea syndrome by an echocardiographic standardized approach: An observational study

Left ventricular diastolic dysfunction in obstructive sleep apnoea syndrome by an echocardiographic standardized approach: An observational study

Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study

Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function

Contact Info

Product

Resources

About