Early Neurodevelopmental Growth in Children With Vertically Transmitted Human Immunodeficiency Virus Infection

Chase, Catharine M.; Vibbert, Martha; Pelton, Stephen I.; Coulter, David L.; Cabral, Howard

doi:10.1001/archpedi.1995.02170210024004

Cited by 49 publications

(35 citation statements)

References 10 publications

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“…HIV encephalopathy as a clinical diagnosis is the umbrella term given to the wide spectrum of presentations seen with CNS infection by HIV (Hilburn, et al, 2010;Sherr, et al, 2009;Van Rie, et al, 2007;Smith et al, 2006;Brouwers, et al, 1995;Chase, et al, 1995;Aylward, et al, 1992;Belman, 1992). It must be noted that there is a distinctly different pattern of clinical presentation seen in children when compared to the dementias seen in adults, due to the effect of the virus on an immature CNS (Smith, et al, 2006;Belman, 1997;Chase, et al, 1995 (WHO, p.37, 2007), which is not feasible for the majority of children living in developing countries.…”

Section: Clinical Manifestations Of Hiv Encephalopathymentioning

confidence: 99%

“…It must be noted that there is a distinctly different pattern of clinical presentation seen in children when compared to the dementias seen in adults, due to the effect of the virus on an immature CNS (Smith, et al, 2006;Belman, 1997;Chase, et al, 1995 (WHO, p.37, 2007), which is not feasible for the majority of children living in developing countries.…”

Section: Clinical Manifestations Of Hiv Encephalopathymentioning

confidence: 99%

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Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Hutchings¹,

Potterton

2013

Vulnerable Children and Youth Studies

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The aim of this cross-sectional study was to determine the difference in development (cognition; receptive and expressive language; and fine and gross motor) of Human Immunodeficiency Virus (HIV) -exposed infected (HEI) infants with the development of HIV-exposed but uninfected (HEU) infants using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Sixty infants were enrolled in the study; 32 (53.33%) HEU infants and 28 (46.67%) HEI infants. The two groups were well-matched for infant demographics, anthropometry at birth, maternal demographics, as well as socioeconomic status. Statistically significant differences were found in anthropometry and development between the HEI and HEU group. The HEI infants had malnutrition, were stunted and had smaller head circumferences than HEU infants. The BSID-III showed that the mean developmental delay for the HEI group was approximately two months below their mean chronological age for all scales (cognitive; receptive and expressive communication; and, fine and gross motor age).The HEI group showed that 64.29% had cognitive delay, 60.71% had language delay and 53.57% had motor delay, all of which was significantly different from the development of the HEU group for all domains (p<0.001). In addition to using the BSID-III, the majority of mothers were able to correctly indicate whether their child was developing at the same, or at a slower rate of development than children of the same age. This study demonstrates that infants who are HIV-exposed and infected are at risk of developmental delay.

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Section: Clinical Manifestations Of Hiv Encephalopathymentioning

confidence: 99%

Section: Clinical Manifestations Of Hiv Encephalopathymentioning

confidence: 99%

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Hutchings¹,

Potterton

2013

Vulnerable Children and Youth Studies

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“…research has failed to control for risk factors other than H N that may affect development (Chase et al, 1995;Nozyce et al, 1994). Our study includes children who reflect the overall population of infants, born to MV-positive mothers.…”

Section: Introductionmentioning

confidence: 99%

Cognitive and motor development in children with vertically transmitted HIV infection

Blanchette¹,

Lou^Smith²,

Fernandes-Penney³

et al. 2001

Brain and Cognition

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“…Among them, the central nervous system (CNS) is frequently affected, causing delays in neurodevelopment that can be one of the first symptoms of the disease [1][2][3][4][5][6]. Children with verticallytransmitted HIV can develop rapid or slow progressive psychoneuromotor development deceleration, which can begin as soon as six months of age.…”

mentioning

confidence: 99%

“…Children with verticallytransmitted HIV can develop rapid or slow progressive psychoneuromotor development deceleration, which can begin as soon as six months of age. Other children may have static encephalopathy [1][2][3][4][5][6].…”

mentioning

confidence: 99%

Neurological profile and neurodevelopment of 88 children infected with HIV and 84 seroreverter children followed from 1995 to 2002

Tahan¹,

Bruck²,

Burger³

et al. 2006

Braz J Infect Dis

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This study evaluated the degree of neurological compromise in HIV-infected children accompanied by the outpatient clinic of infectious diseases and pediatric neurology of the Clinical Hospital of the Federal University of Paraná (UFPR) starting in 1995. Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P <0.01). In the CAT/ CLAMS test, the development quotient (DQ) of the HIV-infected group was significantly lower than that of the HIV-seroreverter group. CAT/CLAMS scores lower than 70 (mental deficiency) were found in 31% of the HIV-infected patients during the first year of life and in only 1% of the patients of the HIV-seroreverter group, demonstrating the validity of this screening test for precocious detection of alterations in the neurodevelopment of infected patients. The same occurred with the Denver I and II tests, as the HIV-infected group failed more frequently than the HIV-seroreverter group. Nine HIVinfected children presented altered brain CT scans; calcification of basal ganglia was the main finding (five cases). Encephalopathy due to HIV causes early arrest of neurodevelopment, which can be detected with screening tests during the first year of life.

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Early Neurodevelopmental Growth in Children With Vertically Transmitted Human Immunodeficiency Virus Infection

Cited by 49 publications

References 10 publications

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Cognitive and motor development in children with vertically transmitted HIV infection

Neurological profile and neurodevelopment of 88 children infected with HIV and 84 seroreverter children followed from 1995 to 2002

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