Early‐onset dementia

Panegyres, Peter K.; Davies, Sue; C, Connor

doi:10.5694/j.1326-5377.2000.tb125651.x

Cited by 13 publications

(11 citation statements)

References 4 publications

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“…Some studies have also found a predominance of early-onset dementia in males. 19 , 20 Lifestyle habits classically associated to men, such as alcoholism and smoking, among others, may influence this finding.…”

Section: Discussionmentioning

confidence: 96%

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Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Souza

Barboza

Gasperin

et al. 2019

Einstein (São Paulo)

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Objective: To evaluate the epidemiological profile of patients seen at a dementia outpatient clinic. Methods: A retrospective study conducted by medical record review searching data on sex, race, age, schooling level, and diagnosis of patients seen from 2008 to 2015. Results: A total of 760 patients were studied, with a predominance of female (61.3%; p<0.0001). The mean age was 71.2±14.43 years for women and 66.1±16.61 years for men. The most affected age group was 71 to 80 years, accounting for 29.4% of cases. In relation to race, 96.3% of patients were white. Dementia was diagnosed in 68.8% of patients, and Alzheimer's disease confirmed in 48.9%, vascular dementia in 11.3%, and mixed dementia in 7.8% of cases. The prevalence of dementia was 3% at 70 years and 25% at 85 years. Dementia appeared significantly earlier in males (mean age 68.5±15.63 years). As to sex distribution, it was more frequent in women (59.6%) than in men (40.4%; p<0.0001; OR=2.15). People with higher schooling level (more than 9 years) had a significantly younger age at onset of dementia as compared to those with lower schooling level (1 to 4 years; p=0.0007). Conclusion: Most patients seen in the period presented dementia, and Alzheimer was the most prevalent disease. Women were more affected, and men presented young onset of the disease. Individuals with higher schooling level were diagnosed earlier than those with lower level.

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Section: Discussionmentioning

confidence: 96%

“…Alguns estudos também demonstraram o predomínio de demência de início precoce no sexo masculino. 19 , 20 Hábitos de vida classicamente mais associados com o sexo masculino, como etilismo e tabagismo, entre outros, podem influenciar em tal achado.…”

Section: Discussionunclassified

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Souza

Barboza

Gasperin

et al. 2019

Einstein (São Paulo)

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“…Males are more likely than female to have had significant head injuries. Within this context, there is a trend towards male predominance among EOD [4, 19, 21, 26, 28-30, 36, 49, 50]. In addition, Fujihara et al [28] reported TBI as an important cause of non-degenerative dementias accounting 9.2% of the patients.…”

Section: Etiology Of Early-onset Dementiamentioning

confidence: 99%

Epidemiology of early-onset dementia: a review of the literature

Vieira

Caixeta

Machado³

et al. 2013

CPEMH

270

166

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Presenile Dementia or Early Onset Dementia (EOD) is a public health problem, it differs from Senile Dementia, and encloses a significant number of cases; nevertheless, it is still poorly understood and underdiagnosed. This study aims to review the prevalence and etiology of EOD, comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies. The computer-supported search used the following databases: Pubmed/Medline, ISI Web of Knowledge and Scielo. The search terms were alcohol-associated dementia, Alzheimer’s disease, dementia, Creutzfeldt-jakob disease, dementia with lewy bodies, early onset dementia, frontotemporal lobar degeneration, Huntington’s disease, mixed dementia, neurodegenerative disorders, Parkinson’s disease dementia, presenile dementia, traumatic brain injury, vascular dementia. Only papers published in English and conducted from 1985 up to 2012 were preferentially reviewed. Neurodegenerative diseases are the most common etiologies seen in EOD. Among the general population, the prevalence of EOD was found to range between 0 to 700 per 100.000 habitants in groups of 25-64 years old, with an increasing incidence with age. The progression of EOD was found to range between 8.3 to 22.8 new cases per 100.000 in those aged under 65 years. Alzheimer's disease (AD) is the major etiology, followed by Vascular Dementia (VaD) and Frontotemporal Lobar Degeneration (FTLD). A larger number of epidemiological studies to elucidate how environmental issues contribute to EOD are necessary, thus, we can collaborate in the planning and prevention of services toward dementia patients.

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“…One reason is that patients with EOD are more likely than those with LOD to have dementias other than AD (see Figure 1) [2,14,20]. Although AD is the most frequent etiology of dementia [2], it account for only about one third of all those with an early age onset, compared to about two thirds (50-75%) of LODs [4,9,[25][26][27]. The other common EODs are vascular dementia (VaD), FTD and related disorders, sequelae from traumatic brain injury (TBI), and alcohol-related dementia [1,4,5,14,20].…”

Section: High Proportion Of Non-ad Dementiasmentioning

confidence: 99%

The Accurate Diagnosis of Early-Onset Dementia

Mendez

2006

Int J Psychiatry Med

156

144

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Early-onset dementia (EOD, <65 years at onset) is a relatively common and frequently misdiagnosed condition. One reason for misdiagnosis is that EOD has a more varied differential diagnosis than late-onset dementia (LOD). For example, Alzheimer's disease (AD), the preponderant LOD, makes up only about one-third of EODs; the rest are due to vascular dementias, frontotemporal lobar degenerations, traumatic head injury, alcohol-related dementia, and a great many other conditions. Another reason for misdiagnosis is that early-onset AD may have predominant cognitive deficits other than memory loss and a potential familial inheritance with spastic paraparesis, seizures, or myoclonus. A third reason is that EOD often presents with neuropsychiatric features out-of-proportion to any cognitive deficits. Despite these obstacles, it is important to accurately diagnose EODs, particularly because they differ in management and course. Clinicians can successfully diagnose most EODs with careful cognitive and family histories, mental status and neurological examinations, and neuroimaging.

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Early‐onset dementia

Cited by 13 publications

References 4 publications

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Prevalence of dementia in patients seen at a private hospital in the Southern Region of Brazil

Epidemiology of early-onset dementia: a review of the literature

The Accurate Diagnosis of Early-Onset Dementia

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