Early-onset oral cancer as a clinical entity: aetiology and pathogenesis

Колегова, Е. С.; Patysheva, Marina; Ларионова, Ирина; Fedorova, I.K.; Kulbakin, D. Е.; Чойнзонов, Е. Л.; Denisov, Evgeny V.

doi:10.1016/j.ijom.2022.04.005

Cited by 22 publications

(22 citation statements)

References 124 publications

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“…14 Cervarix TM medication is now advised for patients between the ages of 10 and 25. 112 11.2.2 | Gardasil ® Gardasil ® , a quadrivalent vaccination, protects against inflammations with four HPV strains, including HPVs −6, −11, −16, and −18, and is made by synthesising VLPs (Virus-Like Particles) for every HPV type using a recombinant Saccharomyces pombe vector. 109,113 Each of the purified VLPs HPV types −6, −11, −16, and −18 is mixed into 20, 40, 40, and 20 g doses on an alum adjuvant proportionately.…”

Section: Therapeutic Diagnosis For Hpv Infectionmentioning

confidence: 99%

“…Furthermore, Cervarix TM continues to work for 5 years 14 . Cervarix TM medication is now advised for patients between the ages of 10 and 25 112 …”

Section: Prevention and Therapeuticsmentioning

confidence: 99%

“…Programs focused on reducing smokeless tobacco use, particularly in areas where there is excessive utilisation of chewing tobacco and betelnut, could serve as the foundation for the prevention of OSCC 112 …”

Section: Prevention and Therapeuticsmentioning

confidence: 99%

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A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

Chakraborty

Ramasubbu

Banerjee

et al. 2023

Reviews in Medical Virology

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Head and neck cancer, one of the most commonly prevalent malignancies globally is a complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx. A specific subgroup of such cancers has been found with some unique chromosomal, therapeutic, and epidemiologic traits with the possibility of affecting via co‐infection. About 25% of all head and neck cancers in the population are human papillomavirus infection (HPV)‐associated, typically developing in the oropharynx, which comprises the tonsils. In the period of efficient combined antiviral treatment, HPV‐positive oral cancers are also becoming a significant contributor to illness and fatality for Human Immunodeficiency Virus (HIV)‐infected persons. Although the prevalence and historical background of oral HPV transmission are not thoroughly understood, it seems likely that oral HPV transmission is relatively frequent in HIV‐infected people when compared to the overall population. Therefore, there is a need to understand the mechanisms leading to this co‐infection, as there is very little research related to that. Hence, this study mainly focus on the therapeutical and biomedical analysis of HPV and HIV co‐infection in the above‐mentioned cancer, including oral squamous cell carcinoma.

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Section: Therapeutic Diagnosis For Hpv Infectionmentioning

confidence: 99%

“…Furthermore, Cervarix TM continues to work for 5 years 14 . Cervarix TM medication is now advised for patients between the ages of 10 and 25 112 …”

Section: Prevention and Therapeuticsmentioning

confidence: 99%

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A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

Chakraborty

Ramasubbu

Banerjee

et al. 2023

Reviews in Medical Virology

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“…1 The vast majority of OSCCs occur in elderly persons, with a long history of exposition to tobacco (all forms, including smokeless tobacco) and use of alcohol, but an alarming increase in the incidence of OSCC in the younger age group (≤45 years old) has been noticed. 3 Other OSCC risk factors are responsible for a very small percentage of cases, such as human papillomavirus (HPV) subtypes 16 and 18, which are more frequently associated with oropharyngeal tumors, or are classified as speculative, including dietary characteristics and oral microbiome and chronic trauma inducing subepithelial inflammation.…”

Section: Introductionmentioning

confidence: 99%

Prognostic markers for oral cancer: An overview of the current status and directions for future research

Oliveira

Almangush

Al‐Samadi

et al. 2023

J Oral Pathology Medicine

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In the last decades, the search for biomarkers for response to therapy and prognosis, with potential of providing information about the likely course and outcome of disease, has been intense in oral squamous cell carcinomas. Although several biomarkers, ranging from genetic and molecular alterations to clinical and histopathological features, have been described, only a few of them are used in routine practice. The aim of this review is to outline the recent advances in oral squamous cell carcinomas biomarkers, exploring those related to clinical and histopathological features, cancer cells and components of the tumor microenvironment. Future directions, highlighting the main issues that limit the clinical application of many of the potential biomarkers, are discussed.

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“… 5 Early-onset oral squamous carcinoma showed a high recurrence rate which was likely to be associated with its specific molecular and immune landscape. 6 The causes that lead to different prognoses in early-onset cancers still remained unclear. Evidence suggests an aetiological role of risk factor exposures in early life and young adulthood.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Model and Nomogram for Early-Onset Adenoid Cystic Carcinoma of Head and Neck: A Retrospective SEER-Based Analysis

Dai

2023

Technol Cancer Res Treat

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Background Adenoid cystic carcinoma of head and neck (ACCHN) is an uncommon head and neck cancers, whose predilection age is 40 to 60. Some studies have revealed that early-onset cancers, such as colorectal cancers and esophageal adenocarcinoma, might present some unique clinicopathological features and have different prognosis with late-onset ones. However, little is known about the early-onset ACCHN. This study aimed to develop a prognostic nomogram for overall survival (OS) of patients younger than 40 with ACCHN. Methods Cases with ACCHN from 1975 to 2016 were retrieved from SEER-18 program. Demographic, clinical, and survival outcomes data of patients were identified for further analysis. The caret package was used to randomly divide early-onset patients into a training cohort and a validation cohort. A prognostic nomogram was constructed based on the univariate and multivariate Cox analysis. The discriminative ability and calibration power of the nomogram was evaluated by the concordance index (C-index), calibration curve, and receiver operating characteristic (ROC) curve. Results A total of 5858 cases with ACCHN were selectively retrieved from SEER program in this study. The number of patients younger than 40, which was defined as early-onset ACCHN in this study, was 825. Based on the outcomes of multivariate analysis, tumor size, chemotherapy, surgery, and stage were selected for the construction of nomogram to predict 10-year OS. The C-index was 0.792 (95%CI 0.760-0.823) and 0.776 (95%CI 0.720-0.832) in the training and validation set, respectively. The area under the ROC curve values were 0.875 (95%CI 0.810-0.940) and 0.833(95%CI 0.754-0.912). The calibration plot indicated that this nomogram had proper calibration in both the training and validation cohorts. Conclusion A novel prognostic nomogram for early-onset ACCHN was constructed and validated in this study. This nomogram could be applied for assisting clinicians to more accurately assess the prognosis of young patients, which might facilitate clinical decision-making and subsequent follow-up.

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Early-onset oral cancer as a clinical entity: aetiology and pathogenesis

Cited by 22 publications

References 124 publications

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

Prognostic markers for oral cancer: An overview of the current status and directions for future research

Prognostic Model and Nomogram for Early-Onset Adenoid Cystic Carcinoma of Head and Neck: A Retrospective SEER-Based Analysis

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