Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

Schweickert, William D.; Pohlman, Mark; Pohlman, Anne S.; Nigos, Celerina; Pawlik, Amy J.; Esbrook, Cheryl L.; Spears, Linda; Miller, Megan; Franczyk, Mietka; Deprizio, Deanna; Schmidt, Gregory A.; Bowman, Amy; Barr, Rhonda; McCallister, Kathryn; Hall, Jesse B.; Kress, John P.

doi:10.1016/s0140-6736(09)60658-9

Cited by 2,811 publications

(2,683 citation statements)

References 51 publications

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“…59,60 If functional impairment is a cause of depression following severe sepsis, then efforts targeting early physical and cognitive rehabilitation in the intensive care unit, which have been shown to improve functional outcomes at hospital discharge, 61 could prevent the development of subsequent depression. Furthermore, since premorbid depression appears to convey considerable risk for substantial symptoms of depression in the aftermath of severe sepsis, hospital programs that target older patients surviving severe sepsis with a prior history of depression—whether or not formally diagnosed—for careful monitoring of their subsequent mental health may improve outcomes.…”

Section: Discussionmentioning

confidence: 99%

Symptoms of Depression in Survivors of Severe Sepsis: A Prospective Cohort Study of Older Americans

Davydow¹,

Hough²,

Langa³

et al. 2013

The American Journal of Geriatric Psychiatry

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Objectives To examine if incident severe sepsis is associated with increased risk of subsequent depressive symptoms and to assess which patient characteristics are associated with increased risk of depressive symptoms. Design Prospective longitudinal cohort study. Setting Population-based cohort of older U.S. adults interviewed as part of the Health and Retirement Study (1998–2006). Participants 439 patients who survived 471 hospitalizations for severe sepsis and completed at least one follow-up interview. Measurements Depressive symptoms were assessed with a modified version of the Center for Epidemiologic Studies Depression Scale. Severe sepsis was identified using a validated algorithm in Medicare claims. Results The point prevalence of substantial depressive symptoms was 28% at a median of 1.2 years before sepsis, and remained 28% at a median of 0.9 years after sepsis. Neither incident severe sepsis [Relative Risk (RR) 1.00, 95%Confidence Interval (95%CI) (0.73, 1.34)] nor severe sepsis-related clinical characteristics were significantly associated with subsequent depressive symptoms. These results were robust to potential threats from missing data or alternative outcome definitions. After adjustment, pre-sepsis substantial depressive symptoms [RR 2.20, 95%CI (1.66, 2.90)] and worse post-sepsis functional impairment [RR 1.08 per new limitation, 95%CI (1.03, 1.13)] were independently associated with substantial depressive symptoms following sepsis. Conclusions The prevalence of substantial depressive symptoms in severe sepsis survivors is high, but is not increased relative to their pre-sepsis levels. Identifying this large subset of severe sepsis survivors at increased risk for major depression, and beginning interventions prior to hospital discharge, may improve outcomes.

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Section: Discussionmentioning

confidence: 99%

Symptoms of Depression in Survivors of Severe Sepsis: A Prospective Cohort Study of Older Americans

Davydow¹,

Hough²,

Langa³

et al. 2013

The American Journal of Geriatric Psychiatry

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“…We evaluated effect of early‐stage rehabilitation on PICS‐related outcomes used our meta‐analysis (8 studies; Brunmmel et al .,441 Burtin et al .,442 Dantas et al .,443 Denehy et al .,444 Jones et al .,445 Kayamabu et al .,446 Pattanshetty et al .,447 and Schweickert et al 231436, 448.…”

Section: Cq18: Icu‐acquired Weakness (Icu‐aw) and Post‐intensive Carementioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

158

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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“…Maßnahmen zur Mobilisation werden in drei Bereiche eingeteilt: die passive Mobilisation, die assistierte aktive Mobilisation und die aktive Mobilisation [3,31,32,49,57,63,77,89] …”

Section: Elemente Der Mobilisationunclassified

Kurzversion S2e-Leitlinie – „Lagerungstherapie und Frühmobilisation zur Prophylaxe oder Therapie von pulmonalen Funktionsstörungen“

Bein

Bischoff²,

Brückner

et al. 2015

Anaesthesist

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Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

Cited by 2,811 publications

References 51 publications

Symptoms of Depression in Survivors of Severe Sepsis: A Prospective Cohort Study of Older Americans

Symptoms of Depression in Survivors of Severe Sepsis: A Prospective Cohort Study of Older Americans

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Kurzversion S2e-Leitlinie – „Lagerungstherapie und Frühmobilisation zur Prophylaxe oder Therapie von pulmonalen Funktionsstörungen“

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