Early Pilomatrix Carcinoma: A Case Report With Emphasis on Molecular Pathology and Review of the Literature

Kamil, Zaid Saeed; Sachdeva, Muskaan; Kwapis, Jessica; Ghazarian, Danny

doi:10.12788/cutis.0393

Cited by 8 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,11,12,15,16 Necrosis has also been observed in relatively well-circumscribed malignant tumors of small size (,1 cm). 17 The lesion in our patient had only atypical mitoses and minor irregularities of its border, features also described in lesions reported as benign melanocytic matricomas 18 or melanocytic matricomas with atypical features. 9,10 On the other hand, in one patient without clinical follow-up, focal irregularities of the tumor circumference were interpreted as a sign of malignant transformation of a pre-existing melanocytic matricoma.…”

Section: Discussionsupporting

confidence: 76%

“…7,11,12,15,16 Necrosis has also been observed in relatively well-circumscribed malignant tumors of small size (<1 cm). 17…”

Section: Discussionmentioning

confidence: 99%

“…23 In addition, by immunohistochemistry, matrical cells are usually BerEP4 negative but BerEP4 expression, focally observed in our case, has been occasionally reported in pilomatrix carcinomas, including an early case. 15–17…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Feoli

Stieber

Bormans

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Melanocytic matricoma is a rare benign pilar tumor characterized by matrical differentiation and interspersed dendritic melanocytes. It may show cellular atypia and brisk mitotic activity. Histological characterization of some lesions may be difficult. In addition, because the reported cases are few and have limited follow-up, there is insufficient experience to define outcome-based criteria for malignancy. Some cases of melanocytic matricoma with more prominent atypia have been reported as malignant, but their clinical behavior is uncertain. We present a melanocytic matricoma with interspersed benign dendritic melanocytes, but moderate basaloid atypia, focally brisk mitotic activity, and atypical mitoses. Despite the apparently good delimitation of this tumor, higher magnification revealed a slightly irregular border. However, overt malignant features such as necrosis, frank asymmetry, deep infiltration, and ulceration were not present. This tumor showed a complex aberrant genomic profile with multiple whole chromosomes or chromosomal arms, losses, and duplications. The tumor mutational burden was high. A loss-of-function alteration in CDKN2A and a loss-of-function mutation in TP53 were also present. This unexpected molecular profile contrasts with the relatively bland histology of the tumor and is in line with the difficulties in microscopic differential diagnosis between melanocytic matricoma and an indolent malignant pilomatrical tumor. We suggest that molecular studies and longer follow-up periods may help to further understand and more precisely categorize borderline pilomatrical tumors with melanocytic hyperplasia.

show abstract

Section: Discussionsupporting

confidence: 76%

“…7,11,12,15,16 Necrosis has also been observed in relatively well-circumscribed malignant tumors of small size (<1 cm). 17…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Feoli

Stieber

Bormans

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Women are more likely to be affected, and studies have not shown racial predilection. 3 All subtypes of anetoderma have a wide variety of distributions, with the most common locations being the trunk, neck, and upper extremities; however, the face, lower extremities, and sacral region may also be affected. 4 Clinically, anetoderma often presents as a protruding, sac-like, circular lesion with wrinkles.…”

Section: Answermentioning

confidence: 99%

“…Secondary anetoderma can occur in the setting of a wide range of dermatologic conditions that arise as a result of autoimmune, infectious, inflammatory, and tumoral conditions. 3 Although the lesions of primary and secondary anetoderma are histologically identical, secondary lesions tend to arise from the areas of the skin affected by a primary disease process. Because there is no apparent underlying dermatologic disease in our patient, this presentation is most consistent with primary anetoderma.…”

Section: Answermentioning

confidence: 99%

Spreading Papules and Nodules in an 11-Year-Old Girl

Peña

Zameza

Ogbonna

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Author Contribution Statement: C. Ahn conceived and designed the study, acquired the data, and approved the version for publication. A. Niehaus participated in the collection and processing of dermatopathological materials. J. Pena analyzed and interpreted the data and constructed and edited the manuscript. P. A. Zameza and C. Ogbonna drafted and revised the manuscript. Data access statement: All data necessary for the case were provided as part of the case. Additional data may be provided upon request.

show abstract

Giant Pilomatrix Carcinoma of the Thorax: An Uncommon and Clinically Misdiagnosed Tumor

Nikolaidou,

Papadopoulou,

Tzimorota

et al. 2023

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Summary: Pilomatrix carcinoma is an unusual and aggressive malignant tumor deriving from follicular matrix cells and exhibiting a metastatic potential to lungs and regional lymph nodes in 10% of cases. We report the case of a 54-year-old male patient who presented with a biopsy-proven malignant pilomatrixoma of the thoracic region, which recurred multiple times after previous excisions. Due to the size of the tumor (28 by 22 cm), wide excision and axillary lymphadenectomy of levels I and II were performed, followed by reconstruction with a free deep inferior epigastric artery perforator flap and adjuvant radiotherapy. Owing to its rarity, this tumor can initially be misdiagnosed, resulting in delayed treatment and recurrences if inadequately excised. Also, large tumor size is correlated with a higher incidence of metastasis. High index of clinical suspicion and wide excision are recommended, along with the need of establishing oncological guidelines for better prognosis.

show abstract

Early Pilomatrix Carcinoma: A Case Report With Emphasis on Molecular Pathology and Review of the Literature

Cited by 8 publications

References 22 publications

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Spreading Papules and Nodules in an 11-Year-Old Girl

Giant Pilomatrix Carcinoma of the Thorax: An Uncommon and Clinically Misdiagnosed Tumor

Contact Info

Product

Resources

About