Early postnatal development of the MDGA2+/- mouse model of synaptic dysfunction

Fertan, Emre; Wong, Aimée A.; Montbrun, Thalia S. Garvock-de; Purdon, Michaela K.; Roddick, Kyle M.; Yamamoto, Tohru; Brown, Richard E.

doi:10.1016/j.bbr.2023.114590

Cited by 3 publications

(1 citation statement)

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“…Altogether, we identified 5 common SV-genes ( DNER , KANK1 , MDGA2 , LRRC36 , and SCFD2 ) under selection during the two stages (stages I and II) of domestication and early development. These genes showed important functions related to neurodevelopment and neurological function ( DNER , KANK1 , and MDGA2 ) [ 32 – 34 ], implying that the transformation of the neutral system may have consistently been selected during the domestication and subsequent development of sheep and goats.…”

Section: Resultsmentioning

confidence: 99%

Structural variant landscapes reveal convergent signatures of evolution in sheep and goats

Yang,

Wang,

Huang

et al. 2024

Genome Biol

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Background Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level reference genome of Asiatic mouflon, and implement a comprehensive analysis of SVs in 897 genomes of worldwide wild and domestic populations of sheep and goats to reveal genetic signatures underlying convergent evolution. Results We characterize the SV landscapes in terms of genetic diversity, chromosomal distribution and their links with genes, QTLs and transposable elements, and examine their impacts on regulatory elements. We identify several novel SVs and annotate corresponding genes (e.g., BMPR1B, BMPR2, RALYL, COL21A1, and LRP1B) associated with important production traits such as fertility, meat and milk production, and wool/hair fineness. We detect signatures of selection involving the parallel evolution of orthologous SV-associated genes during domestication, local environmental adaptation, and improvement. In particular, we find that fecundity traits experienced convergent selection targeting the gene BMPR1B, with the DEL00067921 deletion explaining ~10.4% of the phenotypic variation observed in goats. Conclusions Our results provide new insights into the convergent evolution of SVs and serve as a rich resource for the future improvement of sheep, goats, and related livestock.

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Section: Resultsmentioning

confidence: 99%