Early Postnatal NT‐3 Gene Delivery Enhances Hearing Acquisition in the Developmental Period

Jin, Yongde; Lyu, Ah-Ra; Park, Sungjae; Xu, Jun; Cui, Jie; Sohn, Kyung-Ah; Hur, Gang Min; Jin, Yulian; Park, Yong‐Ho

doi:10.1002/lary.26130

Cited by 3 publications

(1 citation statement)

References 48 publications

(107 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the administration of exogenous neurotrophic factors has been widely studied in animal models of SNHL, showing a pro-survival effect for auditory neurons in models of SNHL [176,237]. A wide number of studies have revealed that BDNF and NT-3 are the most common neurotrophic factors used in animal models of hearing loss [238][239][240][241][242][243][244][245][246][247][248][249][250][251][252][253].…”

Section: Bdnf Protective Effects Against Hearing Lossmentioning

confidence: 99%

The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

Pisani

Paciello

Vecchio

et al. 2023

JPM

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and in sensory structures including olfactory and auditory systems. Many studies have highlighted the protective effects of BDNF in the brain, showing how it can promote neuronal growth and survival and modulate synaptic plasticity. On the other hand, conflicting data about BDNF expression and functions in the cochlear and in olfactory structures have been reported. Several clinical and experimental research studies showed alterations in BDNF levels in neurodegenerative diseases affecting the central and peripheral nervous system, suggesting that BDNF can be a promising biomarker in most neurodegenerative conditions, including Alzheimer’s disease, shearing loss, or olfactory impairment. Here, we summarize current research concerning BDNF functions in brain and in sensory domains (olfaction and hearing), focusing on the effects of the BDNF/TrkB signalling pathway activation in both physiological and pathological conditions. Finally, we review significant studies highlighting the possibility to target BDNF as a biomarker in early diagnosis of sensory and cognitive neurodegeneration, opening new opportunities to develop effective therapeutic strategies aimed to counteract neurodegeneration.

show abstract

Section: Bdnf Protective Effects Against Hearing Lossmentioning

confidence: 99%

The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

Pisani

Paciello

Vecchio

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

Opposite Roles of NT-3 and BDNF in Synaptic Remodeling of the Inner Ear Induced by Electrical Stimulation

Chen

Zhang

et al. 2020

Cell Mol Neurobiol

View full text Add to dashboard Cite

Tissue engineering strategies for spiral ganglion neuron protection and regeneration

Zhang,

Hu,

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

Cochlear implants can directly activate the auditory system’s primary sensory neurons, the spiral ganglion neurons (SGNs), via circumvention of defective cochlear hair cells. This bypass restores auditory input to the brainstem. SGN loss etiologies are complex, with limited mammalian regeneration. Protecting and revitalizing SGN is critical. Tissue engineering offers a novel therapeutic strategy, utilizing seed cells, biomolecules, and scaffold materials to create a cellular environment and regulate molecular cues. This review encapsulates the spectrum of both human and animal research, collating the factors contributing to SGN loss, the latest advancements in the utilization of exogenous stem cells for auditory nerve repair and preservation, the taxonomy and mechanism of action of standard biomolecules, and the architectural components of scaffold materials tailored for the inner ear. Furthermore, we delineate the potential and benefits of the biohybrid neural interface, an incipient technology in the realm of implantable devices. Nonetheless, tissue engineering requires refined cell selection and differentiation protocols for consistent SGN quality. In addition, strategies to improve stem cell survival, scaffold biocompatibility, and molecular cue timing are essential for biohybrid neural interface integration. Graphical Abstract

show abstract

Early Postnatal NT‐3 Gene Delivery Enhances Hearing Acquisition in the Developmental Period

Abstract: NA Laryngoscope, 126:E379-E385, 2016.

Cited by 3 publications

References 48 publications

The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

Opposite Roles of NT-3 and BDNF in Synaptic Remodeling of the Inner Ear Induced by Electrical Stimulation

Tissue engineering strategies for spiral ganglion neuron protection and regeneration

Contact Info

Product

Resources

About