Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitis

Felice, Claudio De; Vacca, Paola; Vecchio, Antonio Del; Criscuolo, Mario; Lozupone, A.; Latini, Giuseppe

doi:10.1007/s00431-004-1488-8

Cited by 14 publications

(13 citation statements)

References 29 publications

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“…The high level of expression of MHC genes in all samples from P32, including amnion, cord, and villus sections, suggests an inflammatory process in this placenta, although, clinically it was considered to be healthy and free of infection. Studies have found subclinical chorioamnionitis, which was discovered incidentally during histopathology of placenta from clinically noninfected women (30). Unfortunately, no samples of the P32 placenta were available for histological analysis.…”

Section: Resultsmentioning

confidence: 99%

Gene expression patterns in human placenta

Sood¹,

Zehnder²,

Druzin

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

405

289

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The placenta is the principal metabolic, respiratory, excretory, and endocrine organ for the first 9 months of fetal life. Its role in fetal and maternal physiology is remarkably diverse. Because of the central role that the placenta has in fetal and maternal physiology and development, the possibility that variation in placental gene expression patterns might be linked to important abnormalities in maternal or fetal health, or even variations in later life, warrants investigation. As an initial step, we used DNA microarrays to analyze gene expression patterns in 72 samples of amnion, chorion, umbilical cord, and sections of villus parenchyma from 19 human placentas from successful full-term pregnancies. The umbilical cord, chorion, amnion, and villus parenchyma samples were readily distinguished by differences in their global gene-expression patterns, many of which seemed to be related to physiology and histology. Differentially expressed genes have roles that include placental trophoblast secretion, signal transduction, metabolism, immune regulation, cell adhesion, and structure. We found interindividual differences in expression patterns in villus parenchyma and systematic differences between the maternal, fetal, and intermediate layers. A group of genes that was expressed in both the maternal and fetal villus parenchyma sections of placenta included genes that may be associated with preeclampsia. We identified sets of genes whose expression in placenta was significantly correlated with the sex of the fetus. This study provides a rich and diverse picture of the molecular variation in the placenta from healthy pregnancies.microarray ͉ pregnancy ͉ transcriptome ͉ preeclampsia T he placenta is a temporary organ that performs the functions of several adult organs for the growing fetus. The placenta is designed uniquely for exchange of oxygen, nutrients, antibodies, hormones, and waste products between the mother and fetus and may carry valuable information about the pregnancy. Although a placenta after delivery is among the most easily accessible human tissues, it is usually discarded after a cursory evaluation (1). Several pregnancy disorders including preeclampsia (PE) and preterm labor are associated with placental pathology. Also, epidemiologic studies suggest that there are ''fetal origins'' that predispose adults to cardiovascular, metabolic, and endocrine diseases (2). Also, low-birth-weight fetuses associated with large placentas are associated with increased neonatal morbidity indicating abnormal placental activity in such scenarios (3, 4). The investigation of placenta may provide valuable insights into placental functions and help identify molecular mechanisms that have both immediate and long lasting effects on health of the fetus.A schematic representation of the placenta is given in Fig. 1, with both the placental disk proper and the reflected membranes. The placenta is a composite organ of trophectoderm-derived cells and cells that are derived from the inner cell mass (ICM)͞epiblast, and a minor co...

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Section: Resultsmentioning

confidence: 99%

Gene expression patterns in human placenta

Sood¹,

Zehnder²,

Druzin

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

405

289

View full text Add to dashboard Cite

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“…Our prior research has generated several early markers for HCA in specific, selected high-risk neonatal categories (22,28,29) and identified HCA as a major predictor of morbidity and mortality among VLBW newborns.…”

Section: Discussionmentioning

confidence: 99%

“…These current limitations have stimulated a search for new, real-time indices of neonatal severity based on different concepts. We have previously assessed the potential value of skin colorimetry (33,34), skin spectrophotometry (35), and pulse oximetry-derived PI (19,21) in identifying different categories of higher-severity newborns.…”

Section: Discussionmentioning

confidence: 99%

Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis

Felice

Goldstein²,

Parrini³

et al. 2006

Pediatric Critical Care Medicine

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“…Studies in the neonatal population have highlighted the potential for PI to be used as an assessment tool in various aspects of an infant's health [6]. In particular, studies have associated PI in the newborn period with subclinical chorioamnionitis [7], as a possible screening tool for the presence of congenital heart malformations [8,9], as a predictor of low superior vena cava flow [10], and as a sign of improved tissue …”

Section: Introductionmentioning

confidence: 99%