Early posttraumatic pulmonary platelet trapping and its potentiation by oral pretreatment with alcohol

Thörne, Johan; Blomquist, Sten; Elmér, Olle; Jönsson, Bo; Lindahl, Sten G. E.; Strand, Sven‐Erik

doi:10.1016/0002-9610(86)90073-5

Cited by 11 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Platelets in the capillaries, however, have not been counted. Platelets have been shown to be entrapped by the lung after trauma [12,13], septic shock [14,15], hemorrhagic shock [16], and acute respiratory failure [17][18][19][20]. Although the pulmonary accumulation of platelets after trauma is reportedly a slow process, the entrapment of platelets after cervical dislocation could have been caused, in part, by associated tissue injury, resulting in the formation in the lung capillaries of microthrombi [21,22].…”

Section: Resultsmentioning

confidence: 99%

“…Ljungqvist et al [12] reported that experimental trauma on the thighs of dogs causes an entrapment of platelets in the lung for a period of 3-4 hour. Thorne et al [13,15] showed that the platelets were trapped in the lung for 2-3 min after experimental trauma or injection of endotoxin. However, these processes reported in the literature took place rather slowly, in contrast to the rapid accumulation observed after cervical dislocation.…”

Section: Discussionmentioning

confidence: 98%

“…The amount of 5HT measured in the lung seemed too high to be attributed to localization in the former two cell types described above. On the other hand, platelets are known to be entrapped by the lung after trauma [12,13], septic shock [14,15], hemorrhagic shock [16] and acute respiratory failute [17][18][19][20]. It is very possible that the high level of 5HT observed in the lung was due to the accumulation of platelets in that organ, but the localization of 5HT in lung tissue has not been determined.…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Cervical dislocation of mice induces rapid accumulation of platelet serotonin in the lung

et al. 1988

View full text Add to dashboard Cite

As much as 3-8 micrograms/g wet weight of serotonin (5-hydroxytryptamine, 5HT) has been detected in mouse lung 10 sec after the animal was sacrificed by cervical dislocation. Perfusion of the lung was carried out to determine where the majority of 5HT was located. Of the total 5HT, 84.3% was measured in the perfusate in which 90-98% was recovered in the platelet-rich fraction. When lungs were dissected from mice without cervical dislocation, either after instantaneous killing by irradiation with high power microwaves or under anesthesia, 5HT in the lung was 0.40-1.60 microgram/g tissue. These results show that cervical dislocation induces the entrapment of platelets in the pulmonary capillaries within 10 sec. The pulmonary accumulation of 5HT induced by cervical dislocation was approximately 50% inhibited by both prazosin and yohimbine, suggesting that the alpha-adrenergic receptor plays some part in the process. Norepinephrine but not isoproterenol augmented by 180% the response of pulmonary 5HT to cervical dislocation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Cervical dislocation of mice induces rapid accumulation of platelet serotonin in the lung

et al. 1988

View full text Add to dashboard Cite

show abstract

“…The amount of '"In tropolone-labeled platelets deposited on the surfaces can be determined. A model for adult respiratory distress syndrome (ARDS) using '"In-oxine-labeled platelets for in vivo studies of platelet activation and trapping in the pulmonary circulation has been developed by a group at the University of Lund, Sweden (98,99). Piglets are subjected to a standardized trauma.…”

Section: In Vivo Platelet Activation Modelsmentioning

confidence: 99%

Porcine platelets in vitro and in vivo studies: Relevance to human thrombosis research

Søfteland

Framstad²,

Thorsen

et al. 1992

European J of Haematology

View full text Add to dashboard Cite

This review summarizes present knowledge on porcine platelets in vitro and recent studies on in vivo activation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed in porcine platelets. Genetic models for von Willebrand disease (vWD) and storage pool deficiency (SPD) have been developed in the pig. Several models for the study of in vivo platelet deposition and early thrombus formation have been developed. Platelet radio‐labeling techniques (with 111In) have been used extensively. We conclude that the pig seems to be a good choice for the investigation of in vivo platelet activation and deposition based on present knowledge of porcine platelets and on already established animal models.

show abstract

“…The temperature of the infúsate in the efferent tubing was 36-38 and 2l-22°C respectively. The dynamic recording of radioactivity over the lungs was followed with a gamma camera as described in a previous study [7]. Samples for peripheral biochemical assessment were ob tained at 0,5,10,30 and 60 min.…”

Section: Methodsmentioning

confidence: 99%

Increased Pulmonary Platelet Sequestration Due to Infusion of Cold Saline during Extracorporeal Circulation

Malmros¹,

Blomquist²,

Mårtensson³

et al. 1993

Nephron

Self Cite

View full text Add to dashboard Cite

We have previously documented that neutrophils (polymorphonuclear leukocytes) aggregate in the lungs 10-15 min after the start of dialysis. The aim of the present study was to investigate the corresponding platelet reaction and evaluate the effect of prewarmed priming solution on this reaction. The animals were divided into two groups, each consisting of 6 pigs. In group 1 the priming solution was prewarmed to 36-38 °C whereas it was maintained at room temperature in group 2. Platelets were selectively labelled with ¹¹¹In-oxine. The activity over the lung was followed dynamically with a gamma camera and already after 2 min a significant difference in platelet sequestration showed between the groups. A significant increase in pulmonary vascular resistance was noted in group 2, but not in group 1. In conclusion, platelet aggregation occurs early on during dialysis in this model. The results also indicate that prewarming the priming solution attenuates the pulmonary platelet sequestration and also seems to decrease the changes in central hemodynamics.

show abstract

Early posttraumatic pulmonary platelet trapping and its potentiation by oral pretreatment with alcohol

Cited by 11 publications

References 13 publications

Cervical dislocation of mice induces rapid accumulation of platelet serotonin in the lung

Cervical dislocation of mice induces rapid accumulation of platelet serotonin in the lung

Porcine platelets in vitro and in vivo studies: Relevance to human thrombosis research

Increased Pulmonary Platelet Sequestration Due to Infusion of Cold Saline during Extracorporeal Circulation

Contact Info

Product

Resources

About