Early Pregnancy Factor Activity in Serum of Patients with Surgical Abortion

Cheng, Shu-Juan; Aiying, Ma; Changxin, Qiao; Zhang, Zheng

doi:10.1111/j.8755-8920.2000.440404.x

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Th ese results are concordant with the previous study about detection of subclinical pregnancy loss using Cp10 in clomiphene citrate cycles (Shahani et al 1995). Cheng et al demonstrated sudden drop in Cp10 to the levels of negative controls in surgical abortion-applied patients aft er 5 -7 days (Cheng et al 2000). Th eir results support our fi ndings about decrease in Cp10 levels from day 2 to day 8 in non-pregnant group (Figure 1a).…”

Section: Discussionsupporting

confidence: 92%

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Taşdemir

Şahin

Çelik

et al. 2014

Journal of Obstetrics and Gynaecology

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The implantation of embryo is one of the crucial steps of a successful pregnancy. The foetus should be protected from maternal immune system, for the appropriate implantation and modification in maternal immunity is crucial. We investigated high-sensitivity C-reactive protein (hs CRP), which is an indicator of low-grade inflammation and Cp10 that has immunosuppressant and growth-promoting capabilities at embryo levels in ovulation induction and intra-uterine insemination (IUI)applied in infertile women. The ovulation induction was maintained by clomiphene citrate or gonadotropins for 42 infertile patients. After successful ovulation induction, IUI was carried out. The blood samples were taken 2 and 8 days after IUI to evaluate Cp10 and hs CRP levels. The pregnant and non-pregnant groups' results were analyzed. The Cp10 levels 8 days after IUI were higher in pregnant group, whereas there was no difference for the 2 days after levels between pregnant and non-pregnant group. The hs CRP levels were similar for both 2nd and 8th days when we compared pregnant and non-pregnant groups. The Cp10 levels increased from day 2 to day 8 in pregnant group. In contrast, the Cp10 levels decreased in non-pregnant group. The change in hs CRP levels from day 2 to day 8 was not significant in pregnant and non-pregnant groups. The Cp10 levels were higher in early phases of fertilisation and elevated through the preceding days of conception in pregnant patients, while it decreased in non-pregnant patients with failed cycles.

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Section: Discussionsupporting

confidence: 92%

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Taşdemir

Şahin

Çelik

et al. 2014

Journal of Obstetrics and Gynaecology

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“…Second, EPF levels fall to normal within 2-5 days after induced abortion (Cheng et al 2000;Hübel et al 1989). This supports EPF's role as a marker for pregnancy as well as non-pregnancy.…”

Section: Early Pregnancy Factor and Lng-ecmentioning

confidence: 54%

Mechanism of Action of Levonorgestrel Emergency Contraception

Kahlenborn¹,

Peck

Severs

2015

Linacre Q

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There has been much debate regarding levonorgestrel emergency contraception's (LNG-EC's) method of action since 1999 when the Food and Drug Administration first approved its use. Proponents of LNG-EC have argued that they have moral certitude that LNG-EC works via a non-abortifacient mechanism of action, and claim that all the major scientific and medical data consistently support this hypothesis. However, newer medical data serve to undermine the consistency of the non-abortifacient hypothesis and instead support the hypothesis that preovulatory administration of LNG-EC has significant potential to work via abortion. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room protocols. In the future, technology such as the use of early pregnancy factor may have the potential to quantify how frequently preovulatory LNG-EC works via abortion. Lay Summary: How Plan B (levonorgestrel emergency contraception) works has been vigorously debated ever since the Food and Drug Administration approved it in 1999. Many doctors and researchers claim that it has either no-or at most-an extremely small chance of working via abortion. However, the latest scientific and medical evidence now demonstrates that levonorgestrel emergency contraception theoretically works via abortion quite often. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room rape protocols.

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“…The maternal immune system must tolerate an allogenic fetus. Early pregnancy factor (EPF) is one early indicator of immunosuppressive activity (Shahani et al 1994, Cheng et al 2000. EPF purifi ed from human platelets is identical to chaperonin 10 (cpn-10) or heat shock protein 10 (HSP-10) (Cavanagh and Morton 1994, Quinn et al 1994, Cavanagh 1996).…”

mentioning

confidence: 99%

Immunohistochemical distribution of early pregnancy factor in ovary, oviduct and placenta of pregnant gilts

Grosso¹,

Bellingeri²,

Motta³

et al. 2014

Biotechnic & Histochemistry

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Early pregnancy factor (EPF) is an immunosuppressant that promotes maternal immune system tolerance of the allogenic fetus. Little is known about localization of this factor in different tissues and nothing has been reported about localization in swine reproductive and placental tissues. We determined the concentration of EPF in serum of gilts and porcine placenta conditioned medium (PPCM). We also analyzed the expression of EPF in different reproductive tissues of pregnant gilts at 10, 30, 60 and 90 days of pregnancy. EPF concentration in serum and PPCM was determined by western blot and densitometry. EPF expression in reproductive tissue was assessed by immunohistochemistry. The highest concentration of EPF was observed at 30 days in serum and PPCM; the concentration was higher in PPCM than in serum at the stages we evaluated. All reproductive tissues from the gestational stages analyzed showed specific labeling of EPF, but this labeling did not appear in non-pregnant gilts. At 30 days pregnancy, the EPF expression in the ovary was predominantly in follicular lutein cells, probably owing to its function as a luteotrophic factor. In the oviduct, EPF was expressed in unciliated secretory epithelial cells and in the cilia of ciliated cells. In the placenta, EPF was expressed in the fetal portion (mesoderm chorioallantois and epithelium of endoderm). EPF acts as an autocrine and paracrine growth factor for the trophoblast during the peri-implantation period.

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Early Pregnancy Factor Activity in Serum of Patients with Surgical Abortion

Abstract: Quantitative study of EPF activity along temporal dimensions (duration) due to surgical abortion further promotes the efficiency to take EPF activity and its rate of change as truly index for monitoring embryonic care and development of normal pregnancy.

Cited by 5 publications

References 5 publications

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Mechanism of Action of Levonorgestrel Emergency Contraception

Immunohistochemical distribution of early pregnancy factor in ovary, oviduct and placenta of pregnant gilts

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