Early Pulmonary Metastasis After a Surgical Resection of Glioblastoma Multiforme. A Case Report

Claudett, Killen Harold Briones; Briones-Claudett, Mónica H; Garcia, Freddy Villacrés; Almeida, Camilo Ortega; Escudero-Requena, Andrea; Solís, Jaime Benítez; Zamora, Killen H. Briones; Marquez, Diana C Briones; Grunauer, Michelle

doi:10.12659/ajcr.922976

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Extracranial metastasis of CNS tumors is rare due to the blood-brain barrier and the absence of lymphatic vessels in the CNS ( 26 , 27 ). The reported incidences of extracranial metastases for GBM vary between 0.4–0.5% ( 26 ), which is comparatively low than the 11% frequency for GS, which is commonly known to metastasize to the lungs, liver, and lymph nodes ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature

Liu

Li²,

Wang³

et al. 2023

Front. Oncol.

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IntroductionSecondary gliosarcomas (SGS) are rare malignancies that are diagnosed subsequent to pre-existing glioma. Clinical features and optimal treatment strategies for SGS have not been conclusively established. This study aimed to assess the clinicopathological features and outcomes of SGS.MethodsWe assessed the clinicopathological features and outcomes of SGS via retrospective analysis of data for SGS patients at Tangdu Hospital. Data from SGS patients in prior publications were also analyzed in accordance with PRISMA guidelines.ResultsEighteen SGS patients who had been treated at Tangdu Hospital between 2013 and 2020 were enrolled in this study. Additional 89 eligible SGS patients were identified from 39 studies. The median age for the patients was 53 years old, and the most common location was the temporal lobe. The most common initial diagnosis was glioblastoma (GBM) (72.0%). Radiology revealed enhanced masses in 94.8% (73/77) of patients. Ten patients (10/107, 9.35%) had extracranial metastases at or after SGS diagnosis. Patients with initial diagnosis of non-GBM and who were younger than 60 years of age were significantly associated with a long duration of disease progression to SGS. After SGS diagnosis, patients with initial non-GBM diagnosis, gross total resection and chemoradiotherapy exhibited prolonged survival outcomes. Patients who had been initially diagnosed with GBM and received both chemoradiotherapy and active therapy after disease progression to SGS, had a significantly longer overall survival than patients who did not.ConclusionInitial diagnosis of GBM was a poor prognostic factor for SGS. Patients who underwent gross total resection and chemoradiation had better overall survival outcomes than those who did not. However, during treatment, clinicians should be cognizant of possible extracranial metastases.

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Section: Discussionmentioning

confidence: 99%

Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature

Liu

Li²,

Wang³

et al. 2023

Front. Oncol.

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“…Similar to our case, the utilization of the cell block technique of pleural fluid in the diagnosis of ECM Glioblastoma was previously reported [ 22 ]. Bronchoscopic biopsy has also been previously utilized in the diagnosis of metastatic glioblastoma [ 20 , 23 , 24 ]. Endobronchial fine-needle aspiration (FNA) biopsy has been reported in the diagnosis of glioblastoma from a metastatic lung mass [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Metastatic Glioblastoma Diagnosed by Endobronchial Ultrasound-Transbronchial Needle Aspiration

Al-Sardi

Alfayez

Alwelaie

et al. 2022

Case Reports in Pulmonology

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Glioblastoma is a common primary brain tumor that has a high mortality rate. Reports of intrathoracic metastases are uncommon, with the most commonly reported site for metastases are the lung and pleura. However, involvement of the mediastinum is not well documented, and few reports of confirmed mediastinal metastases diagnosed by endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) exist. Herein, we report a rare case of metastatic glioblastoma to the thorax. A lady in her 40s has been previously diagnosed with intracranial glioblastoma with multiple incidences of disease recurrence despite treatment with chemoradiotherapy, adjuvant chemotherapy, and repeated surgical resections. She presented with dyspnea and pleural effusion, for which radiological imaging revealed lung, pleural, and mediastinal lesions. Further diagnostic workup with EBUS and pleural fluid sampling confirmed metastatic disease to both sites. The pleural fluid showed highly atypical cells positive for GFAP, and EBUS-TBNA immunostains were GFAP, S100, and synaptophysin positive, giving an overall picture consistent with metastatic glioblastoma. The patient was referred for palliative care, and unfortunately, she passed away after several months.

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Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original Case Series and Systematic Review of the Literature

Laurin,

Treffy,

Connelly

et al. 2024

World Neurosurgery

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Early Pulmonary Metastasis After a Surgical Resection of Glioblastoma Multiforme. A Case Report

Cited by 3 publications

References 10 publications

Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature

Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature

A Rare Case of Metastatic Glioblastoma Diagnosed by Endobronchial Ultrasound-Transbronchial Needle Aspiration

Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original Case Series and Systematic Review of the Literature

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