Early risk factors for pubertal asthma

Hovland, Vegard; Riiser, Amund; Mowinckel, P.; Carlsen, Kai Håkon; Carlsen, Kai‐Håkon

doi:10.1111/cea.12409

Cited by 19 publications

(22 citation statements)

References 56 publications

(104 reference statements)

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“…These results were supported by others studies showing that early severe LRTIs are associated with up to a four‐fold risk of subsequent wheezing during early school years . In addition the number and severity of early life bronchial obstructive episodes has been shown to have the greatest impact on risk of pubertal asthma . Recent research from Copenhagen Prospective Studies on Asthma in Childhood revealed that otherwise healthy children experienced a median of 10 episodes of respiratory tract infections (one episode per child for LRTIs) during the first three years of life .…”

Section: Discussionsupporting

confidence: 56%

Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren

2018

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Aim: The aim of this study was to identify possible risk factors for current asthma revealed by two studies in Northern Norway in 1985 and 2008 and to evaluate these factors contributing to the increased prevalence of asthma over these 23 years.Methods: As part of the 'Asthma and allergy study among schoolchildren in Nordland county' we performed a case-control study (70.0% attendance) comparing 153 children with current asthma (cases) to their non-asthmatic controls. The results from this 2008 study were compared to a similar case-control study (93.2% attendance) performed in 1985 based on 62 current asthmatics.Results: In 1985, the most important risk factors for current asthma were repeated lower respiratory tract infections (LRTIs) with adjusted odds ratio (aOR) 52.11, together with urticaria ever and atopic disease in the family. In 2008, the most important risk factors were food allergy with aOR 7.06, LRTIs during the first three years of life with aOR 5.80 and hospitalisation caused by LRTIs.Conclusion: In both studies, LRTI was the most important risk factor for current asthma.Whether or not LRTIs have contributed to the increased asthma prevalence in this population over 23 years remains unresolved.

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Section: Discussionsupporting

confidence: 56%

Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren

2018

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“…A total of 20 studies were chosen:345678910111213141516171819202122 17 prospective cohort studies 3456891011121314151819202122 and 3 national registry studies 71617. Most studies used general population samples, although not all were nationally representative.…”

Section: Evidence Of the Impact Of Prenatal Maternal Distress On Allementioning

confidence: 99%

“…Most studies used general population samples, although not all were nationally representative. Prenatal maternal distress had a close association with wheezing/asthma in 17 studies346789101112131415161718192122 and atopic dermatitis in 5 studies 511122022. Two studies reported good relationships with both asthma and atopic dermatitis 1122.…”

Section: Evidence Of the Impact Of Prenatal Maternal Distress On Allementioning

confidence: 99%

Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways

Suh

Chang

Lee

et al. 2017

Allergy Asthma Immunol Res

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Recent studies have suggested a close association between prenatal maternal distress and allergic diseases in the offspring. We selected relevant birth-cohort or national registry studies using a keyword search of the PubMed database and summarized current evidence on the impact of prenatal maternal distress on the development of offspring's allergic diseases. Moreover, we postulated possible pathways linking prenatal distress and allergic diseases based on relevant human and animal studies. Both dysregulated hypothalamic-pituitary-adrenal axis and increased oxidative stress may cause structural (altered brain/lung development) and functional (skewed immune development) changes, which may predispose the fetus to developing allergic diseases during childhood. Although many facts are yet to be discovered, changes in the placental response and epigenetic modification are presumed to mediate the whole process from maternal distress to allergic diseases. Maternal prenatal distress can also interact with other physical or environmental factors, including familial or physical factors, indoor and outdoor pollutants, and early childhood psychological distress. The gut-microbiome-brain axis and the role of the microbiome as an immune modulator should be considered when investigating the stress-allergy relationship and exploring potential intervention modalities. Further research is needed, and particular attention should be given to defining the most vulnerable subjects and critical time periods. To this end, studies exploring relevant biomarkers are warranted, which can enable us to explore adequate intervention strategies.

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“…Puberty and adolescence were featured by asthma in puberty (Hovland et al. ) and incident wheezing and asthma in adolescence (Hedman et al. ).…”

Section: Asthma and Rhinitismentioning

confidence: 99%

Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy

Roberts

Boyle

Bryce

et al. 2016

Clin Experimental Allergy

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SummaryIn the second of two papers, we describe developments in the field of clinical allergy as documented by Clinical and Experimental Allergy in 2015. Epidemiology, clinical allergy, asthma and rhinitis are all covered.In this second of two reviews, we discuss the new findings in the field of allergy in 2015 focusing on clinical aspects. These highlight the contribution published in Clinical and Experimental Allergy. We focus on epidemiology, clinical allergy, asthma and rhinitis. Epidemiology GeneralThe research field of allergy-related diseases is complex since we often lack firm data on exposure, and outcome is not easy to estimate as diagnosis is often more subjective compared to other disease areas. Additionally we lack high-quality registries. Such registries are based on a doctor's willingness to enter patient data. Such registers give us a good description of entered patients although we do not know what data are excluded. However, the situation is improving with i-technology. In some EU countries, there are now inpatient, outpatient and national registers including registers for twins. However, a lot of information for epidemiological research in the field of allergy related diseases is still based on questionnaire data, where the quality of the collected information is not always known.

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Early risk factors for pubertal asthma

Abstract: Important early risk factors for pubertal asthma were early airways obstruction, parental rhinitis, being the firstborn child, and perinatal familial stress.

Cited by 19 publications

References 56 publications

Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren

Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren

Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways

Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy

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