Early salivary changes in multiple myeloma patients undergoing autologous <scp>HSCT</scp>

Leeuwen, S van; Proctor, Gordon; Potting, Carin; Hoopen, S ten; Groningen, Lfj van; Bronkhorst, Ewald M.; Blijlevens, N.M.A.; Huysmans, M.C.D.N.J.M.

doi:10.1111/odi.12866

Cited by 11 publications

(14 citation statements)

References 27 publications

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“…4). Several studies have demonstrated decreased salivary flow rate during APSCT under the influence of conditioning treatment 6 , in concert with our results (Fig. 4).…”

Section: Discussionsupporting

confidence: 92%

“…There is impairment of salivary antimicrobial defence and mucosal integrity during APSCT 6,49 . Thus, we can conclude that postmenopausal hormonal changes increase the risk of OM that occurs during APSCT.…”

Section: Discussionmentioning

confidence: 99%

“…Excretion of chemotherapeutic drugs in the saliva is locally cytotoxic 2,5 . Decreased salivary flow rate and altered saliva composition may enhance OM risk and severity 6 . Despite strenuous efforts in research and therapy, OM treatment remains mainly supportive and palliative with basic oral care, pain control, feeding and prevention of infections 7 .…”

Section: E2mentioning

confidence: 99%

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Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation

Gebri

Kiss

Tóth

et al. 2020

Sci Rep

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Oral mucositis (OM) is a frequent complication of stem cell transplantation-associated toxicity in haematological malignancies, contributing to mortality. Therapy still remains mainly supportive. We assessed risk factors in retrospective analysis of 192 autologous peripheral stem cell transplantation patients with lymphoma and multiple myeloma (MM), respectively. Futhermore, we examined the hormone levels both in serum and saliva during transplantation in 7 postmenopausal female patients with lymphoma compared to healthy controls using electrochemiluminescence immunoassay (ECLIA). Multivariable analysis revealed neutrophil engraftment (p < 0.001; p = 0.021) and female sex (p = 0.023; p = 0.038) as independent predictive factors in the combined patient group and in the lymphoma group, and neutrophil engraftment (p = 0.008) in the MM group. Of the 85 female participants 19 were pre- and 66 postmenopausal. Fifteen of the pre-, and 49 of the postmenopausal women developed ulcerative mucositis (p = 0.769), more often with lymphoma than MM (p = 0.009). Serum estrogen decreased significantly both in postmenopausal controls and transplantated patients compared to premenopausals, with no difference in saliva. Serum progesterone level was significantly (p = 0.026) elevated at day + 7 of transplantation, while salivary progesterone increased at day + 7 and + 14. Our results indicate a predominantly negative effect of female sex hormones on oral immunity with role in the aetiopathogenesis of OM.

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“…4). Several studies have demonstrated decreased salivary flow rate during APSCT under the influence of conditioning treatment 6 , in concert with our results (Fig. 4).…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: E2mentioning

confidence: 99%

See 1 more Smart Citation

Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation

Gebri

Kiss

Tóth

et al. 2020

Sci Rep

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“…Therefore, despite the increased permeability of the glomerular filter in NS, capillary permeability of the salivary gland appears to be unaffected. Decreased serum protein levels correlate with changes in saliva composition that are evident in other diseases [10,11] and corroborate the intimate relation between serum and saliva characteristics. Furthermore, similar correlations have been shown between saliva and systemic markers for various conditions such as diabetes [8] and autoimmune disorders [9] in adults.…”

Section: Discussionsupporting

confidence: 73%

Salivary Cytokines in Children with Nephrotic Syndrome versus Healthy Children: A Comparative Study

Polak

Borovitz

Clyman-Levy

et al. 2020

JCM

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Background: The aims of this study were to compare salivary cytokines and total protein between children with nephrotic syndrome (NS) and healthy children, and to examine whether saliva parameters can differentiate between steroid sensitivity and resistance and between disease remission and relapse. Methods: Twenty-seven children with nephrotic syndrome were classified according to steroid sensitivity and resistance, and disease remission and relapse. Twenty healthy children served as controls. Whole saliva samples were collected from all the participants. Urine and blood tests done on the same day as the saliva collection were recorded. Salivary total protein was quantified using bicinchoninic acid and IFNγ, IL-4, IL-8, IL-6, and IL1β levels using ELISA. Results: The mean ages of the nephrotic syndrome and control groups were 11.3 ± 2.4 and 9 ± 4.2, respectively. Compared to the control group, for the nephrotic syndrome group, total salivary protein was significantly lower, as were the levels of all the cytokines examined except IFNγ. Statistically significant differences were not found in any of the salivary markers examined between the children with nephrotic syndrome who were treatment sensitive (n = 19) and resistant (n = 8). Protein and IL-8 salivary levels were lower in the active (n = 7) than in the remission (n = 20) group. Conclusions: Salivary parameters distinguished children with nephrotic syndrome in relapse from healthy children. This may be due to decreased salivary protein excretion, which reflects decreased plasma levels, consequent to proteinuria. Accordingly, salivary markers may be developed as a diagnostic or screening tool for NS activity.

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“…Therefore, despite the increased permeability of the glomerular lter in NS, capillary permeability of the salivary gland appears to be unaffected. Decreased serum protein levels correlate with changes in saliva composition that are evident in other diseases [10,11], and corroborate the intimate relation between serum and saliva characteristics. Furthermore, similar correlations have been shown between saliva and systemic markers for various conditions such as diabetes [8] and autoimmune disorders [9] in adults.…”

Section: Discussionsupporting

confidence: 72%

Salivary cytokines in children with nephrotic syndrome versus healthy children: a comparative study

Pollák

Borovitz

Levy

et al. 2020

Preprint

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Background: The aims of this study were to compare salivary cytokines and total protein, between children with nephrotic syndrome and healthy children; and to examine whether saliva parameters can differentiate between steroid sensitivity and resistance, and between disease remission and relapse. Methods: Twenty-seven children with nephrotic syndrome were classified according to steroid sensitivity and resistance, and disease remission and relapse. Twenty healthy children served as controls. Whole saliva samples were collected from all the participants. Urine and blood tests done on the same day as the saliva collection were recorded. Salivary total protein was quantified using bicinchoninic acid; and IFNγ, IL-4, IL-8, IL-6 and IL1β levels using ELISA. Results: The mean ages of the nephrotic syndrome and control groups were 11.3±2.4 and 9±4.2, respectively. Compared to the control group, for the nephrotic syndrome group, total salivary protein was significantly lower; as were the levels of all the cytokines examined except IFNγ. Statistically significant differences were not found in any of the salivary markers examined, between the children with nephrotic syndrome who were treatment sensitive (n=19) and resistant (n=8). Protein and IL-8 salivary levels were lower in the active (n=7) than in the remission (n=20) group. Conclusions: Salivary parameters distinguished children with nephrotic syndrome in relapse from healthy children. This may be due to decreased salivary protein excretion, which reflects decreased plasma levels, consequent to proteinuria. Accordingly, salivary markers may be developed as a diagnostic or screening tool for NS activity.

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Early salivary changes in multiple myeloma patients undergoing autologous HSCT

Abstract: Compositional changes in saliva reflecting inflammation were found in the first days after HSCT, and the use of cryotherapy in the second part was associated with decreased OM severity.

Cited by 11 publications

References 27 publications

Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation

Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation

Salivary Cytokines in Children with Nephrotic Syndrome versus Healthy Children: A Comparative Study

Salivary cytokines in children with nephrotic syndrome versus healthy children: a comparative study

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