Early Serum Acetaminophen Levels: How Soon Is Too Soon?

Sonochemical synthesis of polyoxometalate-stabilized gold nanoparticles for point-of-care determination of acetaminophen levels: preclinical study in an animal model

“…4 Currently, the Rumack-Matthew nomogram (plot of serum AP concentration vs. time aer acute ingestion) is used to determine patients who require NAC and patients who have serum AP levels below the treatment line will not need treatment. 5 This study aimed to develop a sensitive, rapid, low cost, and green nanosensor for the quantitative determination of toxic levels of AP in blood serum in the early hours aer ingestion. Recently, the detection of AP has received much attention from the analytical chemistry eld where a variety of analytical methods have been developed, including titrimetric methods, 6 high-performance liquid chromatography (HPLC), 7 spectrophotometry, 8 chemiluminescence, 9 and electrochemical analysis.…”