Early serum interleukin-8 evaluation may prove useful in localizing abnormally implanted human gestations after in vitro fertilization

Morelli, Sara S.; Keegan, D.A.; Krey, L.C.; Katz, Joseph; Liu, Mengling; Noyes, N.

doi:10.1016/j.fertnstert.2007.10.063

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Data on interleukins are inconsistent. Serum levels of interleukin 6, 8 and tumor necrosis factor-α were described to be increased in patients with ectopic pregnancy [56], but some studies also showed decreased interleukin-8 levels [57]. Contradictory to our data is the finding of an increased ratio of TNF-α and IL-10 on infertile compared to fertile patients [61].…”

Section: Discussionsupporting

confidence: 59%

“…Data published so far showed no unequivocal impact of omega-3-fatty acid supplementation on sIL-2R serum levels, some studies describe no influence [52][53], others a decrease of serum levels [54][55]. The level of sIL-2R could not be correlated with the risk of ectopic pregnancies [56][57]. But increased levels were recognized as negative prognostic criteria for the success of IVF-treatments [58].…”

Section: Discussionmentioning

confidence: 97%

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Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of invitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 97%

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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“…When taking into consideration that IL-8 has also been detected in unstimulated cycles [38], the involvement of this chemokine in the natural process of folliculogenesis and ovulation can be assumed [42]. Moreover, a recent study showed that lower serum levels of IL-8 correlated with a higher risk for extrauterine pregnancy [43]. Thus, our finding of higher follicular fluid IL-8 in cases of normal intrauterine pregnancy seems sensible.…”

Section: Discussionmentioning

confidence: 71%

Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

Sarapik

Velthut

Haller-Kikkatalo

et al. 2012

Clinical and Developmental Immunology

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Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1β, IL-6, IL-18, IFN-γ, IFN-α, TNF-α, IL-12, and IL-23;, and anti-inflammatory: G-CSF), chemokines (MIP-1α, MIP-1β, MCP-1, RANTES, and IL-8), and other biomarkers (sAPO-1/Fas, CD44(v6)) in 153 women undergoing in vitro fertilization (IVF). Cytokine origin was studied by mRNA analysis of granulosa cells. Higher follicular MIP-1α and CD44(v6) were found to correlate with polycystic ovary syndrome, IL-23, INF-γ, and TNF-α with endometriosis, higher CD44(v6) but lower IL-β and INF-α correlated with tubal factor infertility, and lower levels of IL-18 and CD44(v6) characterized unexplained infertility. IL-12 positively correlated with oocyte fertilization and embryo development, while increased IL-18, IL-8, and MIP-1β were associated with successful IVF-induced pregnancy.

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“…On the other hand, unbalanced inflammation during early stages of gestation may lead to negative consequences. IL-10 appears to be the most powerful immunosuppressive factor produced locally in gestational tissues [18,19]. Studies on human decidua and endometrium have shown negative effect of IL-10 deficit on pregnancy maintenance [20].…”

Section: біологічні наукиmentioning

confidence: 99%

Асоціація Звичного Невиношування Вагітності З Алельними Варіантами Генів IL8 Та IL10

Kucherenko

Gulkovskyi

Hazhylenko³

et al. 2014

ScienceRise

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The study evaluated IL8 -781C/T and IL10 -592C/A, -1082A/G polymorphisms association with recurrent pregnancy loss (RPL) (n=110 case, n=106 control). IL10 -592АА genotype and -1082A allele carriers frequency was higher in RPL group (6.6 %, 87.3 %) comparing to control (0.9 %, 76.4 %). The -1082A allele carriers have twice increased RPL risk (OR=2.12; CI95 %: 1,(3)(4)34). Keywords: IL8 gene/ IL10 gene/ interleukin/ recurrent pregnancy loss. НВ (6,6 %, 87,3 %) порівняно з контрольною (0,9 %, 76,4 %). Ризик невиношування у носіїв алелю -1082A вдвічі вище (OR = 2,12; CI95 %: 1,(3)(4)34).Дата надходження рукопису 15.08.2014Kucherenko Anastasiia, PhD student, junior research fellow, Department of general and molecular genetics,

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Early serum interleukin-8 evaluation may prove useful in localizing abnormally implanted human gestations after in vitro fertilization

Cited by 11 publications

References 27 publications

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

Асоціація Звичного Невиношування Вагітності З Алельними Варіантами Генів IL8 Та IL10

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