Early shoulder-girdle MRI findings in severe COVID-19–related intensive care unit-acquired weakness: a prospective cohort study

Daste, Camille; Mihoubi, Fadila; Rören, Alexandra; Dumitrache, Alina; Carlier, Nicolas; Benghanem, Sarah; Ruttimann, Aude; Mira, Jean‐Paul; Pène, Frédéric; Roche, Nicolás; Séror, P.; Nguyen, Christelle; Rannou, François; Drapé, Jean‐Luc; Lefèvre-Colau, Marie-Martine

doi:10.1007/s00330-023-09468-5

Cited by 1 publication

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“…Magnetic resonance imaging (MRI) of skeletal muscles demonstrates distinctive alterations in the involved muscles, including hyperintensity in T2-weighted and short-tau inversion recovery (STIR) sequences [ 14 , 15 , 16 ]. These signal patterns are suggestive of edema as the underlying pathomorphological substrate and have been demonstrated to resolve in parallel to clinical recovery of several months [ 17 , 18 ]. Persistent MRI alterations correlate with prolonged weakness and disability [ 19 ].…”

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confidence: 99%

Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions

et al. 2023

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Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to evaluate alternative compliance-independent methods, such as muscle biopsies, nerve conduction studies, electromyography and serum biomarkers. However, they are invasive, time-consuming and often require special expertise to perform, making them vastly impractical for daily intensive care medicine. Ultrasound is a broadly accepted, non-invasive, bedside-accessible diagnostic tool and well established in various clinical applications. Hereby, neuromuscular ultrasound (NMUS), in particular, has been proven to be of significant diagnostic value in many different neuromuscular diseases. In ICUAW, NMUS has been shown to detect and monitor alterations of muscles and nerves, and might help to predict patient outcome. This narrative review is focused on the recent scientific literature investigating NMUS in ICUAW and highlights the current state and future opportunities of this promising diagnostic tool.

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