Early skeletal hyperostoses secondary to 13-cis-retinoic acid

Pennes,; Ellis, Charles N.; Kc, Madison; Jj, Voorhees; Martel, William

doi:10.2214/ajr.142.5.979

Cited by 55 publications

(23 citation statements)

References 21 publications

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“…Other hypotheses have suggested that DISH may be related to disorders of vitamin A metabolism (Pennes et al, 1984;Abiteboul & Arlet, 1985) and to idiopathic hypoparathyroidism (Lambert & Becker, 1989), or that it is the result of a vascular disorder (el Miedany et al, 2000) or repeated microtrauma (Pappone et al, 1996).…”

Section: Aetiologymentioning

confidence: 99%

DISH and the monastic way of life

Rogers

Waldron

2001

Intl J of Osteoarchaeology

127

122

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Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition and its prevalence increases markedly with age. This paper describes the pathology and aetiology of the condition; DISH seems to be related to obesity and type II diabetes and is probably a multisystem hormonal disorder. DISH occurs frequently in human skeletal remains, particularly in those recovered from monastic sites. Evidence is presented to confirm this association and the causes are discussed. We also present criteria for the diagnosis of DISH in human remains, which we suggest would permit valid inter-study comparisons.

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Section: Aetiologymentioning

confidence: 99%

DISH and the monastic way of life

Rogers

Waldron

2001

Intl J of Osteoarchaeology

127

122

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“…Excessive ossification of the vertebral bodies and bones of the extremities (diffuse idiopathic skeletal hyperostosis or DISH) after administration of isotretinoin (13-cis-retinoic acid) at a high dose for 1 year was reported by Pennes et al [11] in 1984. Osteophyte formation and ligament calcification induced by long-term oral etretinate administration was reported by Burge and Ryan [1].…”

Section: Discussionmentioning

confidence: 99%

“…However, early diagnosis is difficult because subjective symptoms, such as arthralgia and limited range of motion of joints, typically are minor [2,11], and the blood calcium, phosphorus, and alkaline phosphatase levels are not abnormal on blood chemistry in many cases [12]. Thus, periodic examination of bone and joint abnormalities by radiography is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…However, abnormal reactions accompanied by bone formation in the osteoarticular region induced by long-term administration of etretinate have been reported [1,2,[9][10][11][12]. We encountered a patient who received continuous treatment of psoriatic erythroderma with etretinate for 7 years, in whom an osseous bridge extended across the acetabulum over the femur on both sides and caused gait disturbance.…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Psoriatic Erythroderma with Bilateral Osseous Bridge Across the Acetabulum

Tsuji

Tomita

Inaoka

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Abnormal reactions accompanied by bone formation in the osteoarticular region induced by long-term administration of etretinate have been reported. We treated a patient who received continuous treatment of psoriatic erythroderma with etretinate for 7 years, and who had an osseous bridge that extended across the acetabulum over the femur on both sides. The patient experienced a major gait disturbance and eventually was unable to walk. Functional gait was restored by resecting the ossified regions and radiotherapy. Histologic sections of the ossified lesions showed enchondral ossification in the ligament attachment site in the joint margin, with advancing ossification along the articular capsule; the pattern was similar to that in diffuse idiopathic skeletal hyperostosis. This is the first report of an osseous bridge associated with long-term administration of etretinate extending across the acetabulum over the femur on both sides.

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“…Clinical application of synthetic retinoids was associated with a pattern of side effects superimposable to hypervitaminosis A, which very often prevented long-term administration at proper dosage (31,55,57). As a matter of fact, natural vitamin A, with or without beta-carotene, is currently being used in most chemoprevention studies on healthy populations (16,65).…”

mentioning

confidence: 99%