Early-stage node negative cervical adenocarcinoma and squamous cell carcinoma show similar survival outcomes after hysterectomy: a population-based study

Abstract

ObjectiveTo investigate the clinicopathological features and outcomes between node-negative, early-stage cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) after hysterectomy.MethodsPatients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stages I–IIA cervical SCC and AC between 1988 and 2013 were retrospectively reviewed using the Surveillance, Epidemiology, and End Results database. We used propensity score-matching to balance patient baseline characteristics. Univariate and multivariate Cox regression analyses were used for prognostic analyses of cause-specific survival (CSS) and overall survival (OS).ResultsA total of 9,858 patients were identified, comprising 6,117 patients (62.1%) and 3,741 (37.9%) patients with cervical SCC and AC, respectively. Compared with cervical SCC, cervical AC cases were more likely to be younger, diagnosed after 2000, white, and have well-differentiated and FIGO stage IB1 disease. For SCC and AC, the 10-year CSS rates were 93.4% and 94.7%, respectively (p=0.011), and the 10-year OS rates were 89.6% and 92.2%, respectively (p<0.001). Multivariate analysis revealed that age, ethnicity, tumor grade, and FIGO stage were independent prognostic factors of CSS and OS, but that histologic subtype was not associated with CSS and OS. In the propensity score-matched patient population, univariate and multivariate analyses also showed that histologic subtype was not associated with survival outcomes.ConclusionCervical AC has equivalent survival to cervical SCC in node-negative, early-stage disease after hysterectomy and lymphadenectomy.

Does adenocarcinoma have a worse prognosis than squamous cell carcinoma in patients with cervical cancer? A real-world study with a propensity score matching analysis

“…However, other studies have reported inconsistent results. Wu et al [ 22 ] and Wang et al [ 23 ] reported an equivalent survival for patients with ADC and patients with SCC. In a retrospective competing-risks regression analysis of 2,108 patients with cervical cancer, Intaraphet et al [ 12 ] observed an association of ADC with poorer survival compared with SCC in advanced stages, while no difference was observed at early stages.…”

Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy

“…Whether patients with different histological subtype have different survival outcomes remains a topic of debate. In some previous studies, for early stage cervical cancer patients treated with hysterectomy and lymphadenectomy, cervical AC exhibited equivalent survival to SCC [9–11]. In some other studies, after radical hysterectomy and lymph node dissection, AC was associated with a poor survival, compared with SCC [12–14].…”

Лікування І Профілактика Променевих Ускладнень При Радіотерапії Раку Шийки Матки

“…Тому на сьогодні в більшості радіологічних центрів використовується класифікація RTOG/EORTC з доповненнями Кооперативної групи дослідників, яка дає більш точну характеристику переважно ранніх токсичних ефектів. Подібна деталізація є доцільною, зважаючи на те, що сучасна терапія онкологічних хворих базується на комбінації променевого лікування з хіміотерапією [9].…”