Early-Stage Primary Bone Lymphoma: A Retrospective, Multicenter Rare Cancer Network (RCN) Study

Cai, Ling; Stauder, Michael C.; Zhang, Yu Jing; Poortmans, Philip; Li, Ye Xiong; Constantinou, N.; Thariat, Juliette; Kadish, Sidney P.; Nguyen, Tan Dat; Kirova, Youlia; Ghadjar, Pirus; Weber, Damien Charles; Bertran, V. Tuset; Ozşahin, Mahmut; Mirimanoff, R.O.

doi:10.1016/j.ijrobp.2011.06.1976

Cited by 57 publications

(72 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, with the development of highly effective chemotherapy regimens and particularly the advent of novel agents, such as the anti-CD20 monoclonal antibody rituximab, the role of radiotherapy has been increasingly questioned by certain researchers (2,(25)(26)(27). Considering current studies and several previously-published studies, patients treated with chemoradiotherapy appeared to present an improved outcome compared with patients receiving single modality therapy (25)(26)(27)(28)(29). These observations require confirmation by prospective studies with larger sample groups, since specific studies appear to disprove them (2,26,27,33,34).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Tong

Zhang

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. Primary bone lymphoma (PBL) is a rare disease, accounting for >1% of all cases of malignant lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common histological type of PBL. The present study reported the case of a 68-year-old male with primary bone DLBCL, originally occurred in the sternum, which is a rare form of presentation. Computed tomography (CT), magnetic resonance imaging and bone emission CT were performed, followed by immunohistochemical analysis of a biopsy specimen, and the results were used to establish the diagnosis. At the time of diagnosis, no osseous involvement was observed. The clinical, radiological and histological features of PBL can mimic other medical conditions, thereby making the diagnosis difficult, and frequently leading to delays in treatment. The present study investigated the clinical features, management and prognosis of PBL, and reviewed previous relevant cases.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The five-year OS rates vary greatly, as demonstrated in clinical trials and retrospective population-based studies (2,9,20,28,29,51,53). In addition, various studies have suggested different prognostic factors, including age (29,50,51,56), gender (10), stage (2), LDH levels (10), lesion range (51) and IPI score (28,56).…”

Section: Discussionmentioning

confidence: 99%

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Tong

Zhang

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Chemotherapy usually consists of CHOP-R (cyclophosphamide, doxorubicin, vincristine, prednisolone with or without rituximab). According to [21], combined chemotherapy is vital in the treatment of PBL. Chemotherapy followed by Radiotherapy is superior in improving overall survival rate.…”

Section: Treatmentmentioning

confidence: 99%

Primary Bone Lymphoma Mimicking as Osteomyelitis: An Unusual Presentation

Badam¹,

Devadoss²,

Balaji³

et al. 2017

J Orthop Oncol

View full text Add to dashboard Cite

Primary Bone Lymphoma is a rare disorder, even though secondary involvement of bone marrow in systemic Lymphoma is common. Most of Primary Bone Lymphomas are Primary Bone Diffuse Large B-cell Lymphomas. We describe a case of Primary Bone Lymphoma, initially treated as Osteomyelitis of unknown etiology. This case shows the difficulties that can occur while diagnosing this entity. We provide an overview of Clinical, Radiological, Pathological characteristics of these rare tumours along with review of Literature.

show abstract

“…Ann Arbor stage IV [4,5]. Due to the rarity of the disease, few series are reported in the literature, and only retrospective multicentre reviews involve high numbers of patients [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Little is reported about surgical procedures, even if surgery does, in some cases, become necessary for fractures or impending fractures. An incidence of orthopaedic surgical procedures other than biopsy, ranging from 13.8 % to 26 % [7][8][9][10] or even 47 % [5], is reported, but most papers either do not mention incidence or type of surgery [4,6,[11][12][13][14][15] or report incomplete data about the surgery performed [16,17]. Therefore, we decided to review our series in a single-centre, consecutive series of patients affected by primary bone lymphoma with the aim of: (1) evaluating incidence of surgery , (2) examining type of surgery and its combination with adjuvant treatment and (3) evaluating whether surgery should precede or follow radiotherapy and chemotherapy treatment.…”

Section: Introductionmentioning

confidence: 99%

Primary lymphoma of bone: outcome and role of surgery

Scoccianti

Rigacci

Puccini

et al. 2013

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Purpose Primary bone lymphoma is a rare disease. Little is reported about surgical procedures in these patients. We evaluated a single-centre consecutive series of 21 patients for results, prognostic factors and surgical treatment. Methods Patient ages ranged from 19 to 82 years. The most frequently affected site was the spine (six cases), followed by the ileum, femur and mandible (three cases each). Four patients were treated with chemotherapy and 17 with chemotherapy and radiation therapy. Six patients were affected by a pathological fracture. Surgery was performed in four patients (19 %), in two cases before chemotherapy, in one case during chemotherapy and in one case after chemotherapy and radiotherapy. Five patients died within the range of three to 36 months after diagnosis. Average follow-up of the remaining patients was 62.8 (19-145) months. Results Overall survival was 74.2 % at five years. The only positive prognostic factor was complete remission after chemotherapy. A trend for better survival was present for International Prognostic Index (IPI) score (P =0.051), under 40 years of age (P =0.10) and abnormal lactate dehydrogenase (LDH) values (P =0.10), but it did not reach statistical significance. Conclusions Surgical treatment should be aimed at restoring function and eliminating pain while minimising delays in the chemotherapy schedule. When feasible, postponing surgery until after chemotherapy is advisable.

show abstract

Early-Stage Primary Bone Lymphoma: A Retrospective, Multicenter Rare Cancer Network (RCN) Study

Cited by 57 publications

References 34 publications

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Primary Bone Lymphoma Mimicking as Osteomyelitis: An Unusual Presentation

Primary lymphoma of bone: outcome and role of surgery

Contact Info

Product

Resources

About