Early surgery vs conservative management among asymptomatic aortic stenosis: A systematic review and meta-analysis

Jaiswal, Vikash; Khan, Nazeer; Jaiswal, Akash; Dagar, Mehak; Joshi, Amey; Huang, Helen; Naz, Hina; Attia, Abdelrahman M.; Ghanim, Mohammed; Baburaj, Abiram; Song, David

doi:10.1016/j.ijcha.2022.101125

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…Patients assigned to early surgery had a significantly lower incidence of the primary composite end point than did those in the conservative arm, according to an intention-to-treat analysis (hazard ratio, 0.46 [95% CI, 0.23–0.90]; p = 0.02). In secondary endpoints, there was no statistically significant difference, even when trends were in line with the primary outcome, such as all-cause death, initial heart failure hospitalizations, significant bleeding or thromboembolic events [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Transcatheter Aortic Valve Replacement vs. Surgical Aortic Valve Replacement for Long-Term Mortality Due to Stroke and Myocardial Infarction: A Meta-Analysis during the COVID-19 Pandemic

et al. 2022

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Background and objectives: One of the leading causes of mortality and morbidity in people over the age of 50 is stroke. The acceptance of transcatheter aortic valve replacement (TAVR) as a treatment option for severe symptomatic aortic stenosis (AS) has increased as a result of numerous randomized clinical trials comparing surgical aortic valve replacement (SAVR) and TAVR in high- and intermediate-risk patients, showing comparable clinical outcomes and valve hemodynamics. Materials and Methods: An electronic search of Medline, Google Scholar and Cochrane Central was carried out from their inception to 28 September 2022 without any language restrictions. Results: Our meta-analysis demonstrated that, as compared with SAVR, TAVR was not linked with a lower stroke ratio or stroke mortality. It is clear from this that the SAVR intervention techniques applied in the six studies were successful in reducing cardiogenic consequences over time. Conclusions: A significantly decreased rate of mortality from cardiogenic causes was associated with SAVR. Additionally, when TAVR and SAVR were compared for stroke mortality, the results were nonsignificant with a p value of 0.57, indicating that none of these procedures could decrease stroke-related mortality.

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Section: Discussionmentioning

confidence: 99%

Transcatheter Aortic Valve Replacement vs. Surgical Aortic Valve Replacement for Long-Term Mortality Due to Stroke and Myocardial Infarction: A Meta-Analysis during the COVID-19 Pandemic

et al. 2022

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“…This meta-analysis was conducted and reported following the Cochrane and PRISMA (preferred reporting items for systematic review and meta-analysis) 2020 guidelines and performed according to established methods, as described previously. [18][19][20][21] The prespecified study protocol has been registered in the PROSPERO (CRD42022357336).…”

Section: Methodsmentioning

confidence: 99%

Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

Jaiswal

Ang

Huang

et al. 2023

Journal of Investigative Medicine

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The association between nonalcoholic fatty liver disease (NAFLD) with cardiovascular and cerebrovascular outcomes, as well as their clinical impact, has yet to be established in the literature. This meta-analysis aims to evaluate the association between the NAFLD patients and the risk of atrial fibrillation (AF), heart failure (HF), stroke, cardiovascular mortality (CVM), and revascularization incidence. We performed a systematic literature search using PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until August 2022. A total of 12 cohort studies with 18,055,072 patients (2,938,753 NAFLD vs 15,116,319 non-NAFLD) were included in our analysis. The mean age of the NAFLD patients group and the non-NAFLD group was comparable (55.68 vs 55.87). The most common comorbidities among the NAFLD patients group included hypertension (38% vs 24%) and diabetes mellitus (14% vs 8%). The mean follow-up duration was 6.26 years. The likelihood of AF (risk ratio (RR), 1.42 (95% CI 1.19, 1.68), p < 0.001), HF (RR, 1.43(95% CI 1.03, 2.00), p < 0.001), stroke (RR, 1.26(95% CI 1.16, 1.36), p < 0.001), revascularization (RR, 4.06(95% CI 1.44, 11.46), p = 0.01), and CVM (RR, 3.10(95% CI 1.43, 6.73), p < 0.001) was significantly higher in the NAFLD patients group compared to that of the non-NAFLD group. However, all-cause mortality was comparable between both the groups of patients (RR, 1.30 (95% CI 0.63, 2.67), p = 0.48). In conclusion, the patients with NAFLD are at increased risk of AF, HF, and CVM.

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“…This study was carried out in compliance with the Preferred Reporting Items for Systematic Review and meta-analysis 2020 (PRISMA) guidelines and performed according to established methods [17] , [18] . A pre-specified study protocol has been registered on PROSPERO (CRD42022363138).…”

Section: Methodsmentioning

confidence: 99%

The racial disparity among post transcatheter aortic valve replacement outcomes: A meta-analysis

Jaiswal

Ang

Hanif

et al. 2023

IJC Heart & Vasculature

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Early surgery vs conservative management among asymptomatic aortic stenosis: A systematic review and meta-analysis

Cited by 9 publications

References 30 publications

Transcatheter Aortic Valve Replacement vs. Surgical Aortic Valve Replacement for Long-Term Mortality Due to Stroke and Myocardial Infarction: A Meta-Analysis during the COVID-19 Pandemic

Transcatheter Aortic Valve Replacement vs. Surgical Aortic Valve Replacement for Long-Term Mortality Due to Stroke and Myocardial Infarction: A Meta-Analysis during the COVID-19 Pandemic

Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

The racial disparity among post transcatheter aortic valve replacement outcomes: A meta-analysis

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