Early toothless condition suppresses cell proliferation in the hippocampal dentate gyrus of SAMP8 mice

Kurata, Chika; Ichihashi, Yukiko; Onishi, Mika; Iinuma, Mitsuo; Tamura, Yasuo; Mori, Daisuke; Kubo, Kin‐ya

doi:10.1016/s0917-2394(12)70261-6

Cited by 3 publications

(7 citation statements)

References 41 publications

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“…The following studies met the inclusion criteria: 1) studies on soft-diet feeding [2,[15][16][17][18][19][20][21][22]; 2) studies on tooth extraction [23][24][25][26][27][28][29][30][31][32][33][34][35][36]; 3) studies on bite-raising [37][38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function

et al. 2020

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Recent results have established that masticatory function plays a role not only in the balance of the stomatognathic system and in the central motor control, but also in the trophism of the hippocampus and in the cognitive activity. These implications have been shown in clinical studies and in animal researches as well, by means of histological, biochemical and behavioural techniques. This systematic review describes the effects of three forms of experimentally altered mastication, namely soft-diet feeding, molar extraction and bite-raising, on the trophism and function of the hippocampus in animal models. Through a systematic search of PubMed, Embase, Web of Science, Scopus, OpenGray and GrayMatters, 645 articles were identified, 33 full text articles were assessed for eligibility and 28 articles were included in the review process. The comprehensiveness of reporting was evaluated with the ARRIVE guidelines and the risk of bias with the SYRCLE RoB tool. The literature reviewed agrees that a disturbed mastication is significantly associated with a reduced number of hippocampal pyramidal neurons in Cornu Ammonis (CA)1 and CA3, downregulation of Brain Derived Neurotrophic Factor (BDNF), reduced synaptic activity, reduced neurogenesis in the Dentate Gyrus (DG), glial proliferation, and reduced performances in behavioural tests, indicating memory impairment and reduced spatial orientation. Moreover, while the biteraised condition, characterized by occlusal instability, is known to be a source of stress, softdiet feeding and molar extractions were not consistently associated with a stress response. More research is needed to clarify this topic. The emerging role of chewing in the preservation of hippocampal trophism, neurogenesis and synaptic activity is worthy of interest and may contribute to the study of neurodegenerative diseases in new and potentially relevant ways.

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Section: Resultsmentioning

confidence: 99%

Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function

et al. 2020

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“…Chronic stress experience is considered to inhibit the neurogenesis in the hippocampal DG region [28,47]. The neurogenesis in the DG region can be confirmed using bromodeoxyuridine (BrdU) labeling [28]. The number of BrdU-positive cells decreased with age both in the control and early toothless mice ( Figure 4A and 4B).…”

Section: Early Toothlessness and Hippocampal Morphologymentioning

confidence: 95%

“…Higher plasma corticosterone levels have been shown in animal as early as 10 days after molar extraction [8,23,25]. We extracted the bilateral maxillary molars at the age of 1 month in senescence accelerated mouse prone 8 (SAMP8) [26][27][28][29]. SAMP8 mice undergo normal maturation up to the age of 6 months, and then exhibit accelerated aging (median life span 12 months compared with 2 or 3 years for other strains).…”

Section: Early Toothlessness and Chronic Stressmentioning

confidence: 99%

“…Chronic immobilization stress also caused significant atrophy in basal dendrites, eliciting structural changes in both apical and basal dendrites [7,36]. Several chronic stress paradigms in rodents showed diminished the spine number and cell proliferation of hippocampal neurons [16,26,28,37]. We investigated effects of early toothless condition on neuron number in hippocampal CA1, CA3 and DG regions (Figure 3).…”

Section: Early Toothlessness and Hippocampal Morphologymentioning

confidence: 99%

“…The plasma corticosterone levels play an important role in regulating the hippocampal neurogenesis [46]. Chronic stress experience is considered to inhibit the neurogenesis in the hippocampal DG region [28,47]. The neurogenesis in the DG region can be confirmed using bromodeoxyuridine (BrdU) labeling [28].…”

Section: Early Toothlessness and Hippocampal Morphologymentioning

confidence: 99%

See 2 more Smart Citations

Relationship between the Early Toothless Condition and Hippocampal Functional Morphology

Iinuma

Kondo²,

Kurahashi³

et al. 2013

Anat Physiol

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Hippocampus is important for learning and memory. This article reviews the recent progress of the relationship between the toothless condition and the hippocampal functional morphology. Tooth loss early in life was generated by extracting the upper molars shortly after tooth eruption in mice or rat. Morphological and physiological studies showed that early toothlessness, acting as a chronic stress, induced constantly elevated levels of corticosterone, leading to morphological and molecular alterations in hippocampus, accompanied by deficits in spatial learning and memory. The early toothlessness may be a risk factor of cognitive impairment. Adequate dental treatments such as denture or dental implants for defective part of teeth are considered to be important for maintaining the hippocampal functions. The possible mechanism of the hippocampal alterations induced by early toothless condition is also discussed.

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Tooth loss causes spatial cognitive impairment in rats through decreased cerebral blood flow and increased glutamate

Luo

Pang

Jiang

2019

Archives of Oral Biology

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Early toothless condition suppresses cell proliferation in the hippocampal dentate gyrus of SAMP8 mice

Cited by 3 publications

References 41 publications

Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function

Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function

Relationship between the Early Toothless Condition and Hippocampal Functional Morphology

Tooth loss causes spatial cognitive impairment in rats through decreased cerebral blood flow and increased glutamate

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