EBNEO commentary: Early human milk fortification in infants born extremely preterm: A randomised trial

Abstract

The aim of this trial (IMPACT-Increased Milk Protein to Accrue Critical Tissue) was to evaluate whether early human milk fortification with a human-derived human milk fortifier resulted in increased fat-free mass (FFM) compared to non-fortified human milk in extremely preterm infants. 1 Authors report on a randomised trial investigating the approach of starting human milk fortification early on enteral feeding Day 2, compared with their practice of feeding unfortified milk until the infant reached full-volume feeding. Though many centres have begun fortifying feedings as early as 40-60 mL/k/day, the intervention in this study, starting with fortified feedings as early as Day 2, is less common and has not been formally studied. The authors found no statistically significant difference in the primary outcome (FFM z-score at term) between the How to cite this article: How HS, Malhotra A, Martin C. EBNEO commentary: Early human milk fortification in infants born extremely preterm: A randomised trial. Acta Paediatr.