Ebola virus and persistent chronic infection: when does replication cease?

Forrester, John V.

doi:10.21037/atm.2018.09.60

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…The use of whole-blood samples from animals for detection of LASV may result in missing the presence of the virus in some animals, as acute-phase viremia is transient in blood, while LASV persists in specific tissues ( 17 ). A similar phenomenon has been reported for Ebola ( 18 , 19 ). Previous findings by Fichet-Calvet et al ( 20 ) indicate that Mastomys spp.…”

Section: Discussionsupporting

confidence: 87%

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria

et al. 2022

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Section: Discussionsupporting

confidence: 87%

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria

et al. 2022

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“…In these patients, certain sites might act as a “viral reservoir”, in which the virus can persist for prolonged periods accompanied by recurrent viral shedding. This phenomenon is not new for RNA viruses, as this has already been described in Ebola virus survivors [ 198 ]. SARS-CoV-2 persistence and recurrent shedding has already been demonstrated in the respiratory tract [ 33 ], but also sites of attenuated immunity such as the testis, eye and brain might potentially preserve the virus for longer times.…”

Section: Discussionmentioning

confidence: 81%

On the whereabouts of SARS-CoV-2 in the human body: A systematic review

et al. 2020

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Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to find good strategies for the containment and treatment of this pandemic virus. Here, we performed a systematic review of the current (pre)published SARS-CoV-2 literature with a focus on the evidence concerning SARS-CoV-2 distribution in human tissues and viral shedding in body fluids. In addition, this evidence is aligned with published ACE2 entry-receptor (single cell) expression data across the human body to construct a viral distribution and ACE2 receptor body map. We highlight the broad organotropism of SARS-CoV-2, as many studies identified viral components (RNA, proteins) in multiple organs, including the pharynx, trachea, lungs, blood, heart, vessels, intestines, brain, male genitals and kidneys. This also implicates the presence of viral components in various body fluids such as mucus, saliva, urine, cerebrospinal fluid, semen and breast milk. The main SARS-CoV-2 entry receptor, ACE2, is expressed at different levels in multiple tissues throughout the human body, but its expression levels do not always correspond with SARS-CoV-2 detection, indicating that there is a complex interplay between virus and host. Together, these data shed new light on the current view of SARS-CoV-2 pathogenesis and lay the foundation for better diagnosis and treatment of COVID-19 patients.

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“…Zaire ebolavirus causes uveitis in EVD survivors [26, 27]. We have identified miRNAs produced in human RPE cells following infection with EBOV.…”

Section: Discussionmentioning

confidence: 99%

Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus

et al. 2019

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Objective Survivors of Ebola virus disease (EVD) are at risk of developing blinding intraocular inflammation—or uveitis—which is associated with retinal pigment epithelial (RPE) scarring and persistence of live Zaire ebolavirus (EBOV) within the eye. As part of a large research project aimed at defining the human RPE cell response to being infected with EBOV, this work focused on the microRNAs (miRNAs) associated with the infection. Results Using RNA-sequencing, we detected 13 highly induced and 2 highly repressed human miRNAs in human ARPE-19 RPE cells infected with EBOV, including hsa-miR-1307-5p, hsa-miR-29b-3p and hsa-miR-33a-5p (up-regulated), and hsa-miR-3074-3p and hsa-miR-27b-5p (down-regulated). EBOV-miR-1-5p was also found in infected RPE cells. Through computational identification of putative miRNA targets, we predicted a broad range of regulatory activities, including effects on innate and adaptive immune responses, cellular metabolism, cell cycle progression, apoptosis and autophagy. The most highly-connected molecule in the miR-target network was leucine-rich repeat kinase 2, which is involved in neuroinflammation and lysosomal processing. Our findings should stimulate new studies on the impact of miRNA changes in EBOV-infected RPE cells to further understanding of intraocular viral persistence and the pathogenesis of uveitis in EVD survivors.

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Ebola virus and persistent chronic infection: when does replication cease?

Cited by 15 publications

References 23 publications

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria

On the whereabouts of SARS-CoV-2 in the human body: A systematic review

Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus

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