Ecabet Sodium

doi:10.1002/9780470909799.ch5

Analytical Methods for Therapeutic Drug Monitoring and Toxicology 2010

DOI: 10.1002/9780470909799.ch5

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Ecabet Sodium

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2024

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Cited by 2 publications

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“…Ecabet® is used for the treatment of reflux esophagitis and peptic ulcer disease. 5 Nevertheless, there are several on-going clinical trials on related abietanes, such as tanshinones and triptolide. 6 For example, ferruginol (5), the simplest phenolic abietane diterpenoid, has recently shown antitumor activity through inhibiting non-small cell lung cancer growth by inducing caspase-associated apoptosis.…”

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confidence: 99%

Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

et al. 2019

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similar chemistry. The combined findings indicate that these abietane-diterpenoid natural product analogues offer a source of novel bioactive molecules with promising pharmacological and drug-likeness properties. ASSOCIATED CONTENT Supporting Information Available: Complete experimental details for the synthesis of compounds 7 and 9-16, including copies of 1 H NMR and 13 C NMR spectra, and for all the biological assays. A list with the complete results of the docking studies carried out on the analyzed targets and SMILES codes is also available in the S.I.

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confidence: 99%

Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

et al. 2019

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Resin acid derivatives: fungicidal properties and prediction of the spectrum of biological activity

Tsyrulnikova,

Popova,

Ivanchenko

et al. 2024

Izvestiâ vuzov. Prikladnaâ himiâ i biotehnologiâ

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Biologically active substances that confer antiviral, anti-tumour and antimicrobial effects, which are found among the components of plant raw materials, as well as the products of their chemical modification, are the subject of considerable research interest. These objects include tricyclic diterpenoids – extractives of wood of abietic and pimaric types (resin acids). The presence of two reaction centres (double bonds and a carboxyl group) in the structure of resin acids opens up a wide range of possibilities for synthesising useful compounds on their basis. One of the most promising areas for the study of resin acids and their derivatives consists assessing their fungicidal properties to inform their introduction into compositions as additives, as well as in the application of protective films to increase the resistance of composite building materials against the aggressive effects of microorganisms. In the present work, the fungicidal activity of the N-phenylimide of maleopimaric acid and its polyfluoroalkyl ethers synthesised by us was evaluated on the cells of the filamentous fungi Aspergillus niger, Alternaria alternata and Penicillium sp. by the rate of colony formation and growth. A comparative analysis of the biological activity of resin acids and their in silico derivatives was performed. According to the AntiBag Pred forecast, the test compounds having the maximum values of the probabilities of the presence and absence of each type of activity are characterised by the manifestation of antibacterial activity in relation to strains of gram-positive bacteria. The results of the predictive model are consistent with previous experimental data. However, AntiFun Pred data related to the calculation of fungicidal activity were not confirmed in vitro.

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Ecabet Sodium

Cited by 2 publications

References 46 publications

Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Resin acid derivatives: fungicidal properties and prediction of the spectrum of biological activity

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