ECG score correlates with myocardial fibrosis assessed by magnetic resonance: A study in Chagas heart disease

Rodríguez‐Zanella, Hugo; Meléndez-Ramírez, Gabriela; Velázquez, Leyli; Meave, Aloha; Alexanderson, E.

doi:10.1016/j.ijcard.2015.03.337

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…This hypothesis is supported by the reported association between mitogen-activated protein kinases and molecular events leading to fibrosis ( 35 , 36 ). Fibrosis induced by inflammatory events is an important step in organ remodeling that is associated with clinical manifestation of T. cruzi infection ( 37 ). Thus, CX3CL1 induced by hypertensive-endothelial cell injury may promote remodeling of healthy organs and potentiate the recovery of previously damaged organs.…”

Section: Discussionmentioning

confidence: 99%

Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection

Silva

Azevedo

Figueiredo

et al. 2018

Braz J Med Biol Res

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Trypanosoma cruzi triggers a progressive inflammatory response affecting cardiovascular functions in humans and experimental models. Angiotensin II, a key effector of the renin-angiotensin system, plays roles in mediating hypertension, heart failure, and inflammatory responses. T. cruzi and AngII can induce inflammatory responses by releasing inflammatory mediators. The aim of this study was to evaluate systemic AngII, tumor necrosis factor (TNF), and CX3CL1 mediators in a two-kidney one-clip (2K1C) renovascular hypertension model using Wistar rats infected with T. cruzi. Our data showed an increase in serum AngII in uninfected and T. cruzi-infected rats 1 week after 2K1C surgery compared to non-2K1C (Sham) animals. The baseline systolic blood pressure was higher in both uninfected and infected 2K1C rats. Despite no difference in circulating parasites in the acute phase of infection, elevated serum TNF and CX3CL1 were observed at 8 weeks post-infection in 2K1C rats in association with higher cardiac inflammatory infiltration. In summary, AngII-induced hypertension associated with T. cruzi infection may act synergistically to increase TNF and CX3CL1 in the 2K1C rat model, thereby intensifying cardiac inflammatory infiltration and worsening the underlying inflammation triggered by this protozoan.

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Section: Discussionmentioning

confidence: 99%

Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection

Silva

Azevedo

Figueiredo

et al. 2018

Braz J Med Biol Res

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“…In the meantime, the duration of the QRS interval has also been directly correlated with the scar and MF size estimated by LGE. Therefore, ECG can also be presented as an attractive screening tool and may allow a simple, first-step process for these patients’ risk stratification [ 111 ].…”

Section: Risk Stratification and Scoresmentioning

confidence: 99%

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

et al. 2021

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Despite nearly a century of research and accounting for the highest disease burden of any parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging diagnosis, primarily due to its poor recognition outside of Latin America. Although initially considered endemic to Central and South America, globalization, urbanization, and increased migration have spread the disease worldwide in the last few years, making it a significant public health threat. The international medical community’s apparent lack of interest in this disease that was previously thought to be geographically restricted has delayed research on the complex host–parasite relationship that determines myocardial involvement and its differential behavior from other forms of cardiomyopathy, particularly regarding treatment strategies. Multiple cellular and molecular mechanisms that contribute to degenerative, inflammatory, and fibrotic myocardial responses have been identified and warrant further research to expand the therapeutic arsenal and impact the high burden attributed to CD. Altogether, cardiac dysautonomia, microvascular disturbances, parasite-mediated myocardial damage, and chronic immune-mediated injury are responsible for the disease’s clinical manifestations, ranging from asymptomatic disease to severe cardiac and gastrointestinal involvement. It is crucial for healthcare workers to better understand CD transmission and disease dynamics, including its behavior on both its acute and chronic phases, to make adequate and evidence-based decisions regarding the disease. This review aims to summarize the most recent information on the epidemiology, pathogenesis, clinical presentation, diagnosis, screening, and treatment of CD, emphasizing on Chagasic cardiomyopathy’s (Ch-CMP) clinical presentation and pathobiological mechanisms leading to sudden cardiac death.

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“…34,35 Rochitte was the first to evaluate the presence of myocardial fibrosis in patients with CHD, patients with structural heart disease had a prevalence of CMR LGE of 84% and 100% in those with a history of ventricular tachycardia. The pattern of LGE was subendocardial or transmural in more than 50% of segments in the absence of coronary artery disease (CAD), supporting the role of dysautonomia and microvascular dysfunction in structural changes in CHD.…”

Section: Intermediate and Chronic Phasesmentioning

confidence: 99%

Advanced Imaging in Chagas Heart Disease: from diagnosis to sudden death risk stratification.

Rodríguez‐Zanella¹,

Salas-Pacheco²,

Meléndez-Ramírez³

et al. 2016

ICFJ

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Chagas disease constitutes a relatively prevalent condition in Latin America and is increasing worldwide, with a wide spectrum of clinical subsets. Imaging modalities are critical for adequate diagnosis, staging and prognosis of this entity. Currently Echocardiography and Cardiac Magnetic Resonance are the most valuable techniques for this purpose. Evidence for both modalities has increased in the last years, as the role of advanced techniques such as Speckle Tracking Echocardiography has been explored. We aim to review the evidence of advanced imaging in the spectrum of patients with Chagas Heart Disease.

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ECG score correlates with myocardial fibrosis assessed by magnetic resonance: A study in Chagas heart disease

Cited by 9 publications

References 9 publications

Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection

Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

Advanced Imaging in Chagas Heart Disease: from diagnosis to sudden death risk stratification.

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