Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Espinosa-Paredes, Daniel Abraham; Cornejo-Garrido, Jorge; Moreno-Eutímio, Mario Adán; Martínez-Rodríguez, Oswaldo Pablo; Jaramillo-Flores, M. E.; Ordaz-Pichardo, Cynthia

doi:10.1080/01635581.2020.1817956

Cited by 16 publications

(4 citation statements)

References 67 publications

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“…Therapeutic compounds known as nutraceuticals have drug-like qualities and are used to treat serious illnesses like cancer, diabetes, atherosclerosis, neurological diseases, and hematological disorders. According to study, health food products contain polyphenols, terpenoids, tannins, alkaloids, and flavonoids, which have a significant potential to combat these fatal diseases (25,28,29). In this review, specific important and pertinent breast cancer processes are highlighted, and nutraceuticals are assessed along with their processes and potential in breast cancer prevention.…”

Section: Breast Cancermentioning

confidence: 99%

Plant-based anticancer compounds with a focus on breast cancer

Hasan-Abad,

Sobhani-Nasab,

Atapour

et al. 2023

Preprint

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Cancer as a terrible disease ranks among the most important healthcare issues confronting humanity, necessitating a proactive approach to treatment. Numerous signaling cascades are involved in the complex process of carcinogenesis. Despite its success, chemotherapy has had some undesirable side effects. Plants offer a rich source of novel substances and represent an exciting new option for cancer research. Plants and plant-derived products are revolutionizing themselves because they are less poisonous, quicker, cheaper, safer, and simpler than standard treatment procedures. Natural products are viewed as viable candidates for the creation of anticancer medicines because of their pleiotropic effects on target events in a variety of ways. The actions of plant-derived products are selective; they damage cancer cells and have no significant effect on healthy cells. Several researches are being conducted on the production of potential candidates from these plant-derived products that can stop or inhibit cancer cell proliferation without causing adverse effects. Numerous plant-derived products and the analogs from which they were derived have been identified as potential anticancer therapeutic possibilities. In this review, we summarize research on botanical products with significant and active anticancer activity and their anticancer constituents, with a focus on breast cancer. This review sought to highlight the most recent advances and key successes in plant-derived products and cancer therapies focusing on nuclear and cellular structures. Furthermore, cancer drugs and their problems are discussed.

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Section: Breast Cancermentioning

confidence: 99%

Plant-based anticancer compounds with a focus on breast cancer

Hasan-Abad,

Sobhani-Nasab,

Atapour

et al. 2023

Preprint

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“…Selenium acts as an antioxidant. Ripened extract of garlic helps in shielding the propagation of cancers [ 72 ]. Ajoene restrained the growth of human breast cancer cells [ 73 ].…”

Section: Anticancer Activity Of Medicinal Plantsmentioning

confidence: 99%

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated Overview

Shrihastini¹,

Muthuramalingam²,

Adarshan

et al. 2021

Cancers

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Cancer is one of the most common malignant diseases that occur worldwide, among which breast cancer is the second leading cause of death in women. The subtypes are associated with differences in the outcome and were selected for treatments according to the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor. Triple-negative breast cancer, one of the subtypes of breast cancer, is difficult to treat and can even lead to death. If breast cancer is not treated during the initial stages, it may spread to nearby organs, a process called metastasis, through the blood or lymph system. For in vitro studies, MCF-7, MDA-MB-231, MDA-MB-468, and T47B are the most commonly used breast cancer cell lines. Clinically, chemotherapy and radiotherapy are usually expensive and can also cause side effects. To overcome these issues, medicinal plants could be the best alternative for chemotherapeutic drugs with fewer side effects and cost-effectiveness. Furthermore, the genes involved in breast cancer can be regulated and synergized with signaling molecules to suppress the proliferation of breast cancer cells. In addition, nanoparticles encapsulating (nano-encapsulation) medicinal plant extracts showed a significant reduction in the apoptotic and cytotoxic activities of breast cancer cells. This present review mainly speculates an overview of the native medicinal plant derived anti-cancerous compounds with its efficiency, types and pathways involved in breast cancer along with its genes, the mechanism of breast cancer brain metastasis, chemoresistivity and its mechanism, bioinformatics approaches which could be an effective alternative for drug discovery.

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“…Nutraceuticals are therapeutic agents that show drug properties and can treat life‐threatening diseases such as diabetes, atherosclerosis, cancer, neurodegenerative diseases, and hematological disorders. According to the research results, polyphenols, terpenoids, tannins, alkaloids, and flavonoids are part of health food products, that have great potential to fight these life‐threatening diseases (Espinosa‐Paredes et al, 2021; George et al, 2021; Gupta, Kazmi, et al, 2021). Certain crucial and relevant processes associated with BC are emphasized in this review, and nutraceuticals and their processes and potentiality to combat BC are reviewed.…”

Section: Introductionmentioning

confidence: 99%

Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

Alharbi

Almalki

Makeen

et al. 2022

Journal of Food Biochemistry

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Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many cancer‐related deaths. Over some years, chemotherapy, hormone treatment, radiation, and surgeries have been used to treat cancer. Unfortunately, these treatment options are unsuccessful due to crucial adverse reactions and multidrug tolerance/resistance. Although it is clear that substances in the nutraceuticals category have a lot of anti‐cancer activity, using a supplementary therapy strategy, in this case, could be very beneficial. Nutraceuticals are therapeutic agents, which are nutrients that have drug‐like characteristics and can be used to treat diseases. Plant nutraceuticals categorized into polyphenols, terpenoids, vitamins, alkaloids, and flavonoids are part of health food products, that have great potential for combating BC. Nutraceuticals can reduce BC's severity, limit malignant cell growth, and modify cancer‐related mechanisms. Nutraceuticals acting by attenuating Hedgehog, Nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), Notch, and Wnt/β‐catenin signaling are the main pathways in controlling the self‐renewal of breast cancer stem cells (BCSCs). This article reviews some important nutraceuticals and their modes of action, which can be very powerful versus BC. Practical applications Nutraceuticals' importance to the control and diagnosis of breast cancer is undeniable and cannot be overlooked. Natural dietary compounds have a wide range of uses and have been used in traditional medicine. In addition, these natural chemicals can enhance the effectiveness of other traditional medicines. They may also be used as a treatment process independently because of their capacity to affect several cancer pathways. This study highlights a variety of natural chemicals, and their mechanisms of action, routes, synergistic effects, and future potentials are all examined.

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Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Cited by 16 publications

References 67 publications

Plant-based anticancer compounds with a focus on breast cancer

Plant-based anticancer compounds with a focus on breast cancer

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated Overview

Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

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