Echo-Computed Tomography Strain Imaging of Healthy and Diseased Carotid Specimens

Boekhoven, RW Renate; Rutten, Mcm Marcel; Sambeek, Mrhm van; Vosse, F.N. van de; Lopata, R.G.P.

doi:10.1016/j.ultrasmedbio.2013.11.026

Cited by 22 publications

(23 citation statements)

References 41 publications

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“…Similar measurements were reported for coronary arteries (Lally et al 2004) and healthy or aneurysmal aortic tissue (Duprey et al 2010;Holzapfel and Ogden 2006;Nicosia et al 2002;Okamoto et al 2002). Inflation testing characterizes the arterial tissue in more physiologic circumstances in vitro, that is, less destructive circumstances, and was previously employed on several types of arteries (Agianniotis et al 2012;Beattie et al 1998;Boekhoven et al 2014;Lopata et al 2014;Schulze-Bauer et al 2003;Vychytil et al 2010).…”

Section: Introductionsupporting

confidence: 52%

“…Next, the original RF data were processed using a 2-D coarse-to-fine displacement estimation algorithm (Lopata et al 2009). A two-step approach was used, for which the parameter settings are described in Boekhoven et al (2014), resulting in displacement fields with a resolution of Fig. 1.…”

Section: Inflation Testingmentioning

confidence: 99%

“…Moreover, the local radial displacements and strains in the wall can be of help in understanding the mechanical behavior of the tissue. Both can be measured with ultrasound (strain) imaging techniques, either in vivo or using the in vitro inflation method (Boekhoven et al 2014;Hansen et al 2013;. From the radiofrequency (RF) data, local deformation fields are estimated and displayed as color overlays on the regular B-mode images, that is, strain imaging (Talhami et al 1994).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries

Boekhoven

Peters

Rutten

et al. 2016

Ultrasound in Medicine & Biology

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Section: Introductionsupporting

confidence: 52%

Section: Inflation Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries

Boekhoven

Peters

Rutten

et al. 2016

Ultrasound in Medicine & Biology

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“…In vitro studies have shown a 3D representation of the 2D strain tensor derived from multi-slice 2D displacement estimations [32,33]. In this approach, the dominant tissue motion in radial direction was aligned with the US beam direction due to the rotational acquisition protocol using the longitudinal axis for rotation.…”

Section: Introductionmentioning

confidence: 99%

Multi-Plane Ultrafast Compound 3D Strain Imaging: Experimental Validation in a Carotid Bifurcation Phantom

Fekkes¹,

Saris²,

Menssen³

et al. 2018

Applied Sciences

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Featured Application: Noninvasive patient-friendly detection of vulnerable plaques in 3D segments of superficial arteries in cardiovascular risk populations.Abstract: Strain imaging of the carotid artery (CA) has demonstrated to be a technique capable of identifying plaque composition. This study assesses the performance of volumetric strain imaging derived from multi-plane acquisitions with a single transducer, with and without displacement compounding. These methods were compared to a reference method using two orthogonally placed transducers. A polyvinyl alcohol phantom was created resembling a stenotic CA bifurcation. A realistic pulsatile flow was imposed on the phantom, resulting in fluid pressures inducing 10% strains. Two orthogonally aligned linear array transducers were connected to two Verasonics systems and fixed in a translation stage. For 120 equally spaced elevational positions, ultrasound series were acquired for a complete cardiac cycle and synchronized using a trigger. Each series consisted of ultrafast plane-wave acquisitions at 3 alternating angles. Inter-frame displacements were estimated using a 3D cross-correlation-based tracking algorithm. Horizontal displacements were acquired using the single probe lateral displacement estimate, the single probe compounded by axial displacement estimates obtained at angles of 19.47 and −19.47 degrees, and the dual probe registered axial displacement estimate. After 3D tracking, least squares strain estimations were performed to compare compressive and tensile principal strains in 3D for all methods. The compounding technique clearly outperformed the zero-degree method for the complete cardiac cycle and resulted in more accurate 3D strain estimates.

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“…Since the mechanical properties of IPH and LRNC are different from those of CA and FB, ultrasound elasticity/strain (rate) imaging methods are introduced in the investigation of vulnerable plaques [5] [6]. With the hypothesis that the tissue structure is looser and less stiff in IPH and LRNC than in CA and FB, higher degree of deformation is expected to present in vulnerable plaques compared to stable plaques.…”

Section: Introductionmentioning

confidence: 99%

A new ultrasound imaging indicator for vulnerability evaluatation of carotid atherosclerotic plaques

Huang

Zhao

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Rupture of atherosclerotic plaques is the key factor leading to ischemic stroke. In conventional ultrasound, B-mode imaging and/or color flow/pulsed wave Doppler can be used to evaluate the stenosis of blood vessels but not the vulnerability of plaques. In this paper, we propose an ultrasound strain rate imaging based indicator called mean maximum strain rate (MMSR) to evaluate the vulnerability of carotid atherosclerotic plaques validated using multi-sequence magnetic resonance (MR) imaging characterization. This indicator was tested on 47 plaques from 34 human subjects. Statistical significance was found (p=0.01) between stable plaques and vulnerable plaques. The sensitivity and specificity at the cost effective point of receiver operating characteristic (ROC) curve is 76% and 81%, respectively. This indicator is shown to be effective in evaluating the vulnerability of carotid atherosclerotic plaques.

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Echo-Computed Tomography Strain Imaging of Healthy and Diseased Carotid Specimens

Cited by 22 publications

References 41 publications

Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries

Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries

Multi-Plane Ultrafast Compound 3D Strain Imaging: Experimental Validation in a Carotid Bifurcation Phantom

A new ultrasound imaging indicator for vulnerability evaluatation of carotid atherosclerotic plaques

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