Echocardiogram Done Early in Neonatal Sepsis: What Does it Add?

Tomerak, Rania Hosny; El-Badawy, Ayman; Hussein, Gehan; Kamel, Nermin R.M.; Razak, Abdel

doi:10.2310/jim.0b013e318249fc95

Cited by 22 publications

(12 citation statements)

References 26 publications

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“…A study conducted by Abtahi and Jafari [3] found that right ventricular and left ventricular Tei indexes were significantly higher in septic neonates as compared to non-septic neonates. Tomerak et al [15] stated significant difference in left ventricular diastolic dysfunction (lower E/A ratio in the septic than the non-septic newborns), while no difference was noticed in the LV systolic function (EF and FS) between septic and non-septic neonates. Abdel-Hady et al [16] stated that the TDI (Tissue Doppler Imaging) indexes of global myocardial function (RV and LV Tei indexes) were significantly higher.…”

Section: Resultsmentioning

confidence: 99%

Cardiac Function Affection in Infants with Neonatal Sepsis

Alzahrani¹

2017

J Clin Trial

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Objective: Neonatal sepsis is associated with the presence of the systemic inflammatory response syndrome (SIRS) in response to a culture-proven infection. It is known as one of the most frequent causes of mortality in the neonatal intensive care units. The study has aimed to investigate the effects of neonatal sepsis on cardiac function of the infants. Methods:The study is based on prospective cohort research. It consists of two groups; control group and focus group. The focus group comprised of 30 full-term neonates with neonatal sepsis admitted to NICU; whereas, healthy neonates were included in the control group. Neonatal sepsis was diagnosed among the infants with the presence of at least two clinical signs of sepsis including feeding intolerance, temperature instability, apnea, poor reflexes, poor capillary refill>2 seconds. The clinical examination of neonates including CBC, CRP, blood culture, and sensitivity was also conducted. Moreover, echocardiography was performed on participants of both groups. Results:The results revealed that 50% of the patients from both the groups were male. The mean weight of the infants ranged from 2.2 to 3.5 kg with a mean of 2.9 ± 0.3 kg. Results showed that 63.3% patients had low platelet count, and 16.7% patients suffered from leukocytosis. 11 patients (36.7%), suffering from sepsis, were diagnosed with significant shift in their neutrophil count. There were significant changes in the echocardiogram of the patients suffering neonatal sepsis; whereas, dramatic improvement in cardiac function was observed by comparing the parameters before and after resolution of sepsis. Conclusion:The septic neonates experienced significant cardiovascular changes that are revealed through the technique known as echocardiography.

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Section: Resultsmentioning

confidence: 99%

Cardiac Function Affection in Infants with Neonatal Sepsis

Alzahrani¹

2017

J Clin Trial

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“…Neonatal sepsis may or may not be associated with left ventricular diastolic dysfunction; however, cardiac injury as manifested by elevated levels of cardiac troponin T may complicate the clinical picture. 492,493 Abnormal peripheral vasoregulation with or without myocardial dysfunction is the primary mechanism for the hypotension accompanying septic shock in the neonate. 494 Therefore, infected neonates may present with hypotension and adequate perfusion (warm shock) or inadequate perfusion (cold shock).…”

Section: Central Nervous Systemmentioning

confidence: 99%

Pathophysiology of Neonatal Sepsis

Wynn¹,

Wong²

2017

Fetal and Neonatal Physiology

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“…15 Another study in preterm neonates also had similar results, with mean LV-MPI of 0.27 (SD 0.16). 1 Several studies on neonatal sepsis in different situations have used MPI and hs-cTnT to diagnose cardiovascular dysfunction. Due to the specificity of cTnT to myocardial tissue and its high sensitivity for myocardial injury, hs-cTnT may be used as a biological marker for myocardial injury.…”

Section: Discussionmentioning

confidence: 99%

Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis

Ramadhina¹,

Sukardi²,

Advani³

et al. 2015

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Background Hemodynamic instability in sepsis, especially in the neonatal population, is one of the leading causes of death in hospitalized infants. The major contribution for heart dysfunction in neonatal sepsis is the myocardial dysfunction that leads to decreasing of ventricular function. The combination of echocardiography and laboratory findings help us to understand the ventricular condition in preterm infants with sepsis.Objective To assess for a correlation between ventricular function and serum high-sensitivity cardiac troponin T (hs-cTnT) level in preterm infants with neonatal sepsis.

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Echocardiogram Done Early in Neonatal Sepsis: What Does it Add?

Abstract: Neonatal sepsis is associated with LV diastolic dysfunction.

Cited by 22 publications

References 26 publications

Cardiac Function Affection in Infants with Neonatal Sepsis

Cardiac Function Affection in Infants with Neonatal Sepsis

Pathophysiology of Neonatal Sepsis

Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis

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