Echocardiographic Diagnosis, Classification, and Dialysis Treatment of Uremic Pericardial Effusion

Matsumoto, Jun; Murata, Toyoaki; Sato, Sotaro; Ichihara, Toshikatsu; Haruyama, Takeshi; Uruga, Kazuo; Kuroda, Hiroshi

doi:10.1620/tjem.130.265

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(1 citation statement)

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“…However, Matsumoto et al’s study in 131 uremic patients, observed that among 65 patients who did not undergo dialysis, 25 of them displayed PE and serum creatinine levels exceeding 5 mg/100 ml. The authors noted an increased likelihood of uremic PE in correlation with elevated creatinine levels within this subgroup [ 36 ]. Additionally, Frommer et al noted in pre-dialysis ESRD patients that those with PE tended to have lower BUN levels [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Pericardial effusion in patients with chronic kidney disease: A two-center study

Eslami,

Mousavi,

Irilouzadian

et al. 2024

PLoS ONE

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Background and aims Pericardial effusion (PE) is a prevalent form of pericardial involvement in chronic kidney disease (CKD). This study aims to investigate the clinical and laboratory features associated with PE severity in patients with CKD. Methods In this cross-sectional study, we examined the medical records of patients admitted to tertiary hospitals with International Classification of Diseases 10th Revision (ICD-10) codes associated with CKD and PE. We included 112 CKD patients in stage 4 and 5 non-dialysis (ND) with PE for assessing the clinical and laboratory features of severity. Results Patients were divided into two categories based on the severity of PE. Seventy-two patients had mild and 40 had moderate and severe PE. Univariate analysis of demographic and laboratory features on the date of admission demonstrated that chest pain, dyspnea, serum albumin, and neutrophil-to-lymphocyte ratio (NLR) are associated with the severity of PE. The univariate analysis on the date of echocardiography showed significantly higher white blood cell count (WBC), neutrophil count (percentage and absolute count), and NLR, along with significantly lower lymphocyte percentage and serum albumin among patients with moderate and severe PE. In the multivariable analysis of laboratory features, on admission hypoalbuminemia (p-value = 0.014, OR = 4.03, CI: 1.32–12.25) and NLR greater than 5.5 (p-value = 0.015, OR = 4.22, CI: 1.32–13.50) were significantly associated with moderate and severe PE. In a parallel matter, at the time of echocardiography hypoalbuminemia (p-value = 0.004, OR = 5.38, CI: 1.74–16.65) and neutrophilia (p-value = 0.005, OR = 7.94, CI: 1.89–33.44) were significantly associated with moderate and severe PE. Conclusion Despite advancements in the diagnosis and treatment of CKD, PE is still a concerning issue in these patients. This study revealed that hypoalbuminemia, neutrophilia, and NLR greater than 5.5 could be predictive factors of moderate and severe PE in CKD patients with PE. Further prospective study with larger sample size is needed to confirm these results.

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Section: Discussionmentioning

confidence: 99%