Anatomically, oral cavity and central nervous system have a close relationship; the mouth and face are the location for 30-40% of the body's sensory and motor nerves. The identification of orofacial manifestations of neurological disorders is usually in direct relation with the responsibilities of a dental surgeon. Therefore, familiarizing dental surgeons with theses manifestations is essential to have better recognition, diagnosis, and correct decisions upon treating their associated Neurological Disorders. These manifestations should be efficiently analyzed using novel effective techniques since their related neurological disorders need to be early identified to avoid serious consequences. Furthermore, preventive dental care for patients with neurological disorders and all kind of rehabilitative treatments necessitates well-planned and effective novel approaches. The Internet of Medical Thing (IoMT) is a relatively new technology that has revolutionized health care sector drastically since last decade. It's a combination of medical sensors and wearable devices that can connect to health care storage systems via networking technologies allowing the transfer of medical data over a secure network. The data transferred are of utmost importance in diseases diagnosis and treatment. In this paper, an IoMT-based Intelligent Guided Particle Local Search with Optimized Neural Networks (IGPLONN) approach is proposed. Firstly, dental data are collected from the International Collaboration on Cancer Reporting (ICCR) oral cavity and central nervous system. Secondly, features are extracted from data and IGPLONN algorithm is utilized to select the effective features by minimizing the feature dimension that helps improve the overall prediction rate. Finally, the obtained features are transferred to the central health application through the IoMT platform where they can be analyzed by dental practitioners for neurological disorders prediction. The hybrid optimized technique improves the overall oral-linked neurological diseases detection rate. Moreover, it efficiently manages the forecast parameters that are used to predict the dental metastasis with minimum computational complexity. The performance of the proposed system has been experimentally evaluated on MATLAB to verify its excellence. The results revealed that proposed IoMT-based IGPLONN method attains the maximum accuracy of 98.3% compared to other methods. INDEX TERMS Oral cavity, neurological disorder, central nervous system, intelligent guided particle local search algorithm, neural network, Internet of Medical Things (IoMT).