Echocardiography Parameters in Patients With Stage 2 Arterial Hypertension Complicated by Chronic Kidney Disease

Abstract

Abstract. The purpose of the research is to explore patient’s echocardiography parameters with stage 2 arterial hypertension complicated by chronic kidney disease (CKD). Material and methods: the study involved 100 patients with stage 2 essential hypertension (46 men and 54 women with average age of 59.09±13.51 years). The first group included patients with arterial hypertension complicated by CKD (50 people). The control group consisted of patients with hypertension, in whom the course of hypertension was not complicated by CKD (50 people) - the 2nd group. In the first two days of hospitalization, blood pressure was measured, blood creatinine was assessed, GFR was calculated, the presence of microalbuminuria was assessed, the threshold of taste sensitivity to table salt (TSTSS) was determined, and a transthoracic echocardiographic study (Echo-CG) was performed. The data are presented in the form of M±SD with a normal distribution of the trait, Me±IQR with a description of the trait different from the normal distribution and a percentage ratio (%). To assess the statistical relationship between the indicators, Spearman's rank correlation coefficient (r) was calculated. Results. The study showed that in patients with hypertension complicated by CKD, there are higher blood pressure numbers, almost half of them have insufficient antihypertensive therapy. They have higher values of indicators characterizing the degree of LV hypertrophy and lower values of ejection fraction than in patients without CKD. A direct correlation was found between PS consumption and echocardiographic parameters characterizing LV size and its hypertrophy in AH patients with CKD. At the same time, these indicators were significantly higher in patients with high PHCPS compared to those with a low threshold. Conclusion. The data obtained from the results of ECHO-CG allow us to expand our understanding of the pathogenesis of AH, taking into account such complications as CKD, and can be used for timely correction of antihypertensive therapy, which will prevent the process of progression of AH staging, before the appearance of systemic complications of CKD, and, therefore, improve the prognosis of the disease.