Eclipta prostrata L. phytochemicals: Isolation, structure elucidation, and their antitumor activity

Liu, Qi-Mei; Zhao, Hang; Zhong, Xian-Ke; Jiang, Jianguo

doi:10.1016/j.fct.2012.08.007

Cited by 86 publications

(71 citation statements)

References 22 publications

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“…This plant has also been reported to have various biological activities, including myotoxicity and inhibitory effects on hemorrhagic blood loss (Melo et al, 1994), and hypolipidemic (Kumari et al, 2006), immunomodulatory (Liu et al, 2001), anti-microbial (Wiart et al, 2004), and anti-inflammatory activities (Kobori et al, 2004). Interestingly, anti-cancer activities have also been suggested (Liu et al, 2012). For example, E. prostrata juice has been shown to inhibit cancer invasion, migration, and angiogenesis (Lirdprapamongkol et al, 2008).…”

Section: Introductionmentioning

confidence: 93%

“…For example, dayscyphin C, a saponin isolated from E. alba, showed cytotoxic activity with an IC 50 value of 50 μg/ml in HeLa cells (Khanna and Kannabiran, 2009). Liu et al (2012) isolated wedelolactone, eclalbasaponin I, luteolin, and luteolin-7-O-glucoside from E. prostrata and found that eclalbasaponin I inhibited the growth of hepatoma smmc-7721 cells, with IC 50 values of 111.17 μg/ml. In the present study, the bioactivity-guided fractionation of a crude ethanol extract of E. prostrata led to the isolation of five terthiophenes.…”

Section: Introductionmentioning

confidence: 99%

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α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells

Lee

Ahn

Cho

et al. 2015

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells

Lee

Ahn

Cho

et al. 2015

Journal of Ethnopharmacology

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“…This plant has been experimentally proven to possesses nephroprotective, cerebroprotective, hepato-protective, anti-cancer, anti-asthma, mosquito larvicidal and ovicidal properties, toxicity against hepatitis-C virus, hair growth promoting activity, immunemodulatory property, antioxidant, lipid lowering activity and anti-venom property (Dungca, 2016;Chaudhary et al 2011;de Freitas Morel et al 2017;Jayathirtha and Mishra, 2004;Datta et al 2009;Govindarajan and Karuppannan, 2011). Presence of wedelolactone, ecliptamines, taraxastane glycosides, polythienyl and other phytochemicals has been reported in this plant (Zhang et al 2010;Liu et al 2012;Han et al 2013). Wedelia calendulacea (L.) (Syn.…”

Section: Introductionmentioning

confidence: 99%

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

Vadivel¹,

Anand²,

Monajkumar³

et al. 2017

Bull. Pharm. Res.

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In Indian system of medicine, Eclipta prostrata is an important herbal ingredient of several Ayurvedic and Siddha formulations and it is commonly called as Bhringraja. But, this plant is often confused with Wedelia calendulacea, which is also known as Bhringraja and also being adulterated in Indian herbal market. In order to differentiate these plant drugs (Eclipta prostrata and Wedelia calendulacea), in the present work we have developed chemical fingerprints. Phytochemical analysis, UV-Visible, FT-IR and NMR spectroscopy, HPTLC and HPLC chromatography were carried out in the selected plant materials. Phytochemical analysis of methanolic extract of investigated materials showed that W. calendulacea contained higher level of total phenolic compounds (381.82 mg GAE/100 g) when compared to E. prostrata (105 mg GAE/100 g). Scanning in UV-Visible spectroscopy exhibited difference between selected samples, especially at 250-450 nm. Similarly, FT-IR spectroscopy of raw materials indicated notable difference between the samples at 400 -1000 cm -1 region. NMR spectroscopy illustrated remarkable difference between the chloroform extract of selected samples at 1-2 ppm region. HPTLC profile of methanolic extract of E. prostrata exhibited a total number of 9 peaks while W. calendulacea showed 12 number of peaks. Chemical profile investigated in the present study would be helpful to differentiate E. prostrata from W. calendulacea and also useful to prevent their adulteration in herbal industry.

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“…E. alba is also included in the family Asteraceae and has very similar shapes with E. prostrata except for smoother margins of leaf blades. E. prostrata has been used as a medicinal plant owing to compounds like Eclalbasaponin I and wedelolactone found in the plant which have antitumor and cirrhosis and hepatitis curing effects (Dalal et al 2010;Liu et al 2012). In addition, it has been used as resources for Chinese tonics to cure loose teeth, tinnitus, hemoptysis, hematuria and uterine bleeding (Chinese Pharmacopoeia Commission 2010).…”

Section: Introductionmentioning

confidence: 99%

Discrimination and Authentication of Eclipta prostrata and E. alba Based on the Complete Chloroplast Genomes

Kim

Park

Lee

et al. 2017

Plant Breed. Biotech.

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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. prostrata is more widely used than E. alba. Morphological semblances have confounded identification of either species. Here, we report the complete chloroplast genomes of both species to provide an authentication system between the two species and understand their diversity. Both chloroplast genomes were 151,733-151,757 bp long and composed of a large single copy (83,285-83,300 bp), a small single copy (18,283-18,346 bp), and a pair of inverted repeats (25,075-25,063 bp). Gene annotation revealed 80 protein coding genes, 30 tRNA genes and four rRNA genes. A phylogenetic analysis revealed that the genus Eclipta is grouped with Heliantheae tribe species in the Asteraceae family. A comparative analysis verified 29 InDels and 58 SNPs between chloroplast genomes of E. prostrata and E. alba. The low chloroplast genome sequence diversity indicates that both species are really close to each other and are not completely diverged yet. We developed six DNA markers that distinguish E. prostrata and E. alba based on the polymorphisms of chloroplast genomes between E. prostrata and E. alba. The chloroplast genome sequences and the molecular markers generated in this study will be useful for further research of Eclipta species and accurate classification of medicinal herbs.

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Eclipta prostrata L. phytochemicals: Isolation, structure elucidation, and their antitumor activity

Cited by 86 publications

References 22 publications

α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells

α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

Discrimination and Authentication of Eclipta prostrata and E. alba Based on the Complete Chloroplast Genomes

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