Ecografía doppler transrectal durante la biopsia prostática: utilidad clínica y limitaciones

Ezquer, Aníbal; Hrescak, M.C. Ortega; Sanagua, C.; Roggia-Rebullida, P.; López, R.A. Medina; Cenice, Fernando; Veglia, Francisco; Fernández, A.

doi:10.1016/j.acuro.2014.02.009

Cited by 11 publications

(3 citation statements)

References 33 publications

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“…Compared to histopathology of the surgical specimen, endorectal power Doppler/grayscale ultrasound-guided biopsies had a moderate working area that detects Gleason scores ≥3+4 at least one time in the collected lesions, lower sensitivity and accuracy, and a higher number of inconclusive results (78; 7%) and false-negative results (145; 13%). The results of the present study were in line with those of previous studies (5,16,34,35). Power Doppler US is not able to differentiate cancerous vascular clustering lesions from hypervascular inflammation (5).…”

Section: Discussionsupporting

confidence: 94%

“…The utility of power Doppler with grayscale ultrasound is used in the detection of prostate cancer (5). Endorectal power Doppler ultrasound may detect capsular extension, visualize tumor vascularity and improve the sensitivity of grayscale ultrasound-guided biopsies (16). All of these pre-operative data should be utilized by the surgeon to perform the best radical prostatectomy technique in order to obtain the best achievable functional result (17,18).…”

Section: Introductionmentioning

confidence: 99%

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Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study

Yuan

Lin

et al. 2019

Exp Ther Med

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Multiparametric MRI fusion with transrectal ultrasound (mpMRI/TRUS)-guided biopsy has the sensitivity of mpMRI with the practicality of TRUS, but males with no cancerous lesion(s) detected on mpMRI have a considerable remaining risk of cancer. Endorectal power Doppler ultrasound improves the sensitivity of grayscale ultrasound-guided biopsies. The objective of the present study was to evaluate the beneficial effect of endorectal power Doppler/grayscale ultrasound-guided biopsy over that of mpMRI/TRUS-guided biopsy for decision-making regarding prostatectomy in males with a high risk of prostate cancer. Data regarding endorectal power Doppler/grayscale ultrasound-guided biopsies and mpMRI/TRUS-guided biopsies of 1,094 males with elevated specific prostate antigen, were included. Radical prostatectomy was performed in males aged <70 years with Gleason scores ≥3+4 in any one of the biopsy reports. The histopathological data of the surgical specimen of 776 males were included in the analysis. Compared to the histopathology of the surgical specimen, endorectal power Doppler/grayscale ultrasound-guided biopsies had a lower sensitivity (0.930 vs. 1.000; P<0.0001) but mpMRI/TRUS-guided biopsies had the same sensitivity (0.990 vs. 1.000; P=0.02). The accuracy of mpMRI/TRUS-guided biopsies was higher than that of endorectal power Doppler/grayscale ultrasound-guided biopsies (0.944 vs. 0.783). On mpMRI, lesions of 105 subjects (10%) with a Likert scale score of <3 were identified. Among them, 14 subjects (2%) had Gleason scores of ≥3+4 as determined by endorectal power Doppler/grayscale ultrasound-guided biopsies. In addition, 20 (2%) false-positive lesions compared to the histopathological analysis of the surgical specimen were identified from mpMRI/TRUS-guided biopsies. In conclusion, mpMRI/TRUS-guided biopsy was indicated to have a moderate performance and endorectal power Doppler/grayscale ultrasound-guided biopsy had a scant performance for decision-making regarding prostatectomy.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study

Yuan

Lin

et al. 2019

Exp Ther Med

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“…There are obvious regional and ethic differences in the pathogenesy of PCa. Currently, the diagnosis of PCa is mainly based on the combination of various procedures, and PCa is usually diagnosed as a localized disease [ 6 , 7 ]. Treatments for PCa predominantly include surgical castration, androgen-deprivation therapy (ADT), and radiation therapy (RT) [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Low LKB1 Expression Results in Unfavorable Prognosis in Prostate Cancer Patients

Sun

et al. 2015

Med Sci Monit

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BackgroundThe present study aimed to compare the expression of liver kinase B1 (LKB1) in prostate cancer (PCa) tissues and the paired adjacent tissues, then to evaluate the statistical relationship between LKB1 expression and prognosis of PCa patients.Material/MethodsThe relative expression of LKB1 at mRNA level was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of LKB1 at protein level was measured by immunohistochemistry (IHC) method. The relationship between LKB1 expression and clinicopathologic characteristics was estimated by chi-square test. Kaplan-Meier method was used to analyze the overall survival of PCa patients with different LKB1 expression. Cox regression analysis was performed to estimate the significance of LKB1 expression and clinicopathologic characteristics in the prognosis of PCa patients.ResultsThe relative expression of LKB1 at mRNA level was significantly lower in PCa tissues than in the normal tissues (P<0.001). The LKB1 expression was proved to be affected by clinical stage (P=0.019) and PSA concentration (P=0.031) of PCa patients. Moreover, patients with negative LKB1 expression had shorter survival than those with positive expression. Cox regression analysis confirmed that LKB1 could be regarded as a prognostic biomarker for PCa patients (P=0.001, HR=3.981, 95% CI=1.698–9.336).ConclusionsThe expression of LKB1 was lower in PCa tissues and might be a predictor for the prognosis of PCa patients.

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The role of multiparametric ultrasound in the detection of clinically significant prostate cancer

Jung

DiNatale

Frankel³

et al. 2022

World J Urol

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Ecografía doppler transrectal durante la biopsia prostática: utilidad clínica y limitaciones

Cited by 11 publications

References 33 publications

Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study

Endorectal power Doppler/grayscale ultrasound‑guided biopsies vs. multiparametric MRI/ultrasound fusion‑guided biopsies in males with high risk of prostate cancer: A prospective cohort study

Low LKB1 Expression Results in Unfavorable Prognosis in Prostate Cancer Patients

The role of multiparametric ultrasound in the detection of clinically significant prostate cancer

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