Ecological and genetic mechanisms of development of epidemiologically significant strains of sapronosis causative agents

Adgamov, Ruslan R.; Тимченко, Н. Ф.; Зайцева, Е. А.; Pushkareva, V. I.; Kolbasov, Denis; Egorova, Irina; Pukhovskaya, N. M.; Musatov, Yu. S.; Иванов, Л. И.; Ermolaeva, S. A.

doi:10.1134/s2079086413020023

Cited by 10 publications

(7 citation statements)

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“…The most important fish pathogens can be generally divided into two groups: those native to natural freshwater habitats and those associated with water pollution. The bacterial species described in this paper, Vibrio spp., Listeria monocytogenes, Salmonella serovars, Clostridium botulinum, and Yersinia spp., represent both groups of bacteria mentioned abovenative freshwater habitats and contaminants arising from different sources, including sewage and direct contamination by wild animals, livestock, and feed (Bottone et al 2005;Adgamov et al 2013). In particular, the human pathogenic Listeria monocytogenes and Yersinia spp.…”

Section: Introductionmentioning

confidence: 98%

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Major foodborne pathogens in fish and fish products: a review

et al. 2015

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Fish plays an important role in the human diet, and there is an observed increase in the consumption of fish per capita in Europe. However, intensive growth of industry and agriculture may cause contamination of natural and humanmade aquatic environments, and may affect not only the health of fish, but also raise safety concerns with regard to fish used for human consumption. It is well known that fish and fish products are often associated with human diseases. Thus, it is necessary to study the prevalence of pathogens in fish to ensure the safety of fish products and environments. Microbial assessment of fish also gives additional information about the hygienic status of environments, including lakes, rivers, ponds, and fish farms. Detection of pathogenic microorganisms or changes in natural microflora in the water environment could be an important indicator of possible contamination. The aim of this review was to describe and discuss the five most relevant bacterial genera and species linked to aquatic environments-Vibrio spp., Listeria monocytogenes, Yersinia spp., pathogenic Salmonella serovars, and Clostridium botulinum-causing human foodborne diseases.

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Section: Introductionmentioning

confidence: 98%

“…In particular, the human pathogenic Listeria monocytogenes and Yersinia spp. were also identified as natural microflora of aquatic systems due to the ability to survive outside host organisms for a long time (Adgamov et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Major foodborne pathogens in fish and fish products: a review

et al. 2015

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“…In the late 20 th century, the existence of resting ("dormant") resistant cell forms was first reported for non-spore-forming bacteria inhabiting soils and water bodies and found in organisms of warm-blooded animals and humans [14]. Subpopulations of these cell forms are characterized by reduced growth rates and metabolic activity, but, with the onset of optimal conditions for growth, they can quickly restore the pathogenic characteristics that they had previously [6,7].…”

Section: Causative Agents Of Sapronosesmentioning

confidence: 99%

“…The formation of resistant forms in causative agents of sapronoses is induced by a number of environmental stress factors (variations in the hydrothermal regime, shortage of nutrients, exposure to antibiotics, etc.) and exhibits a pronounced adaptive property [1,6].…”

Section: Causative Agents Of Sapronosesmentioning

confidence: 99%

“…Despite the rather long history of the study of sapronoses, the newly forming ideas about symbiotic relationships, parasitic systems, and adaptation strategies of their causative pathogens increasingly diverge from the classical epidemiological and biological concepts [3]. This is explained in part by the lack of both generally accepted The resistant cell forms with low metabolic and replication activity cannot be detected by traditional microbiological methods [6,7]. These forms are highly significant for a large and diverse group of causative agents of sapronoses, as they allow them to implement their biological properties: environmental plasticity, a variety of forms of resistance to external stressors, the acquisition of resistance to antibiotics and other antibacterial agents [5,8].…”

Section: Introductionmentioning

confidence: 99%

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Toxin–Antitoxin Systems and their Role in Maintaining the Pathogenic Potential of Causative Agents of Sapronoses

Andryukov

Сомова

Timchenko

et al. 2020

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: In interepidemic periods, a sapronoses typically employs a variety of mechanisms for maintaining viability of its causative agent in terrestrial parasitic systems, associated with different adaptive strategies utilized by its populations to survive. Unlike spore-forming bacteria, causative agents of sapronoses use resistant cell forms, which is a viable but nonculturable (VBNC) state, and persistence. Implementation of these strategies is conditioned by effects of various stress factors of the habitat and is characterized by decreased metabolism, alteration of the morphology and physiology of bacterial cell, and cessation of its replication. It is important that the resistant forms of cells retain virulence and, as favorable conditions come, turn back into the active vegetative form again. The discovery of the genetic modules of bacterial toxin–antitoxin systems (TAS) in recent years has made it possible to identify a number of complicated regulatory molecular mechanisms responsible for maintaining the pathogenic potential of resistant forms of causative agents of natural-focus sapronoses in interepidemic periods. Based on the key role of TAS in the survival of pathogenic bacteria and in the progress of infection, the modern technologies, used to create alternative antibacterial strategies, consider these systems as promising goals for the development of new antimicrobial targets.

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