Ecological risk assessment and long-term environmental pollution caused by obsolete undisposed organochlorine pesticides

Mit, Natalya; Cherednichenko, Oksana; Mussayeva, A. S.; Khamdiyeva, Ozada; Amirgalieva, Almira; Begmanova, Mamura; Tolebaeva, Anar; Koishekenova, Gulshat; Zaypanova, Saule; Pilyugina, Anastassiya; Amandykova, Makpal; Tlenshieva, Arshyn; Nurzhanova, Asil; Mamirova, Aigerim; Bekmanov, Bakhytzhan; Djansugurova, Leyla

doi:10.1080/03601234.2021.1913931

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…The total concentrations of DDTs and its metabolites were at 10.07 and 0.343 µ g/g respectively for soils from K and B sites according to previous studies [5]. Similarly, another study focused on a contaminated site in the village Kyzylkairat found OCPs, including DDTs and HCHs, in all analyzed soil samples, with concentrations ranging from 0.0014 to 11.1µg /g for DDT and its metabolites which is respectively close for the K and B sites [9].…”

Section: Ta100 Strain Responsesupporting

confidence: 67%

Assessment of the genotoxic potential of soil-associated DDTs and its metabolites using the Salmonella/microsome assay

Turganova,

Koishekenova,

Zaypanova

et al. 2024

BIO Web Conf.

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The study aimed to assess the genotoxicity of different DDT contaminated soils (with different amendment types) in benzene extracts. A Salmonella/microsome assay without metabolic activation (-S9) was performed to evaluate the efficiency to initiate the mutations of remediated and non-remediated soils. The number of revertants mutations in his+ in TA100 and TA98 strains were obtained, and compared to soils without DDT, and remediated DDT containing soils. The interpretation of the data suggests that, mutagenic activity was high for the non-remediated soils samples Kyzylkairat and Beskainar, and revealed in the scale as a weak mutagen. Soil samples treated with DARCO, ORBO, Sarg<150μm, and Sarg>150μm in Kyzylkairat and Beskainar exhibited a decreasing level of mutagenic activity, which is in line with the decreased environmental availability in these soil. Overall, the study indicates that strains TA100 and TA98 are valuable tools for rapidly assessing the potential mutagenicity of soil contaminated with OCPs.

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Section: Ta100 Strain Responsesupporting

confidence: 67%

Assessment of the genotoxic potential of soil-associated DDTs and its metabolites using the Salmonella/microsome assay

Turganova,

Koishekenova,

Zaypanova

et al. 2024

BIO Web Conf.

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“…The selection of a study cohort was carried out taking into account previous studies in the frame of the project “Comprehensive Assessment of the Impact of Non-utilized and Banned Pesticides on the Genetic Status and Health of the Population of the Almaty Region” (BR05236379, 2018–2020). Collected biosamples are presented in the gene bank of the Institute of Genetics and Physiology (Almaty, Kazakhstan) [ 17 , 18 , 19 ]. The materials for this study were personal data, general health survey data, and EDTA-treated frozen peripheral blood samples.…”

Section: Methodsmentioning

confidence: 99%

“…Beskaynar, v. Kyzylkairat, v. Belbulak, v. Amangeldy, v. Enbekshi; collection of 2021—v. Karakestek, v. Umbetali, v. Akdala) [ 18 ]. The main selection criteria were living for more than 10 years near sources of pesticide contamination.…”

Section: Methodsmentioning

confidence: 99%

“…These villages are located on the territory of national natural reserves. Previously (2021), it had been shown that soil and water samples from these territories were not contaminated by pesticides [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…This study is part of the results of a complex project devoted to evaluating the ecological situation of populated territories of the Almaty region contaminated by banned organochlorine pesticides over 10 years. The results indicated that organochlorine pesticides and their decay products entered the human food chain and influenced the level of chromosome aberrations and somatic health status [ 15 , 16 , 17 , 18 , 19 , 20 ]. The impact of many factors on health status was estimated in a recently published article [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.

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Exploring the potential of CoMoO4-modified graphitic carbon nitride to boost oxidation of amoxicillin micropollutants in hospital wastewater

Thi,

Bui,

Nguyen

et al. 2024

Environ Geochem Health

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Ecological risk assessment and long-term environmental pollution caused by obsolete undisposed organochlorine pesticides

Cited by 12 publications

References 25 publications

Assessment of the genotoxic potential of soil-associated DDTs and its metabolites using the Salmonella/microsome assay

Assessment of the genotoxic potential of soil-associated DDTs and its metabolites using the Salmonella/microsome assay

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Exploring the potential of CoMoO4-modified graphitic carbon nitride to boost oxidation of amoxicillin micropollutants in hospital wastewater

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