Ecological risk under the dual threat of heavy metals and antibiotic resistant Escherichia coli in swine-farming wastewater in Shandong Province, China

Liu, Cong; Feng, Chenglian; Duan, Yuanpeng; Wang, Peng; Peng, Chong; Li, Zixuan; Yu, Liang; Liu, Mengda; Wang, Fangkun

doi:10.1016/j.envpol.2022.120998

Cited by 26 publications

(6 citation statements)

References 63 publications

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“…These mechanisms include genes affecting antibiotic efflux, reduced permeability to antibiotics, antibiotic inactivation, and antibiotic target replacement. ST48 is associated with a potential zoonotic risk [ 41 ]. In our study, ST48 strains were classified as group A and exhibited resistance to antibiotics from five classes.…”

Section: Discussionmentioning

confidence: 99%

Unveiling Antibiotic Resistance, Clonal Diversity, and Biofilm Formation in E. coli Isolated from Healthy Swine in Portugal

Silva,

Dapkevicius

et al. 2024

Pathogens

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Escherichia coli, a commensal microorganism found in the gastrointestinal tract of human and animal hosts, plays a central role in agriculture and public health. Global demand for animal products has promoted increased pig farming, leading to growing concerns about the prevalence of antibiotic-resistant E. coli strains in swine populations. It should be noted that a significant portion of antibiotics deployed in swine management belong to the critically important antibiotics (CIA) class, which should be reserved for human therapeutic applications. This study aimed to characterize the prevalence of antibiotic resistance, genetic diversity, virulence characteristics, and biofilm formation of E. coli strains in healthy pigs from various farms across central Portugal. Our study revealed high levels of antibiotic resistance, with resistance to tetracycline, ampicillin, tobramycin, and trimethoprim-sulfamethoxazole. Multidrug resistance is widespread, with some strains resistant to seven different antibiotics. The ampC gene, responsible for broad-spectrum resistance to cephalosporins and ampicillin, was widespread, as were genes associated with resistance to sulfonamide and beta-lactam antibiotics. The presence of high-risk clones, such as ST10, ST101, and ST48, are a concern due to their increased virulence and multidrug resistance profiles. Regarding biofilm formation, it was observed that biofilm-forming capacity varied significantly across different compartments within pig farming environments. In conclusion, our study highlights the urgent need for surveillance and implementation of antibiotic management measures in the swine sector. These measures are essential to protect public health, ensure animal welfare, and support the swine industry in the face of the growing global demand for animal products.

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Section: Discussionmentioning

confidence: 99%

Unveiling Antibiotic Resistance, Clonal Diversity, and Biofilm Formation in E. coli Isolated from Healthy Swine in Portugal

Silva,

Dapkevicius

et al. 2024

Pathogens

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“…The findings revealed severe pollution from both zinc and iron, and a high degree of resistance in most E. coli isolates to chloramphenicol, tetracyclines, and sulfonamides. The clonal complex 10 was prevalent, and multidrug-resistant E. coli was found to be extensively distributed [ 19 , 20 ]. Meanwhile, several other studies suggested that the spread of antibiotic-resistant genes could be influenced by the contamination of heavy metals.…”

Section: Viewpoint and Discussion With Conclusionmentioning

confidence: 99%

Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Muteeb

2023

Microorganisms

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Antibiotic usage and resistance are major health concerns. Antibiotic resistance occurs when bacteria evolve to resist the effects of antibiotics, making it impossible to treat infections. The overuse and misuse of antibiotics are the main contributing factors, while environmental stress (such as heavy metals accumulation), unhygienic conditions, illiteracy, and unawareness also contribute to antibiotic resistance. The slow and costly development of new antibiotics has lagged behind the emergence of antibiotic-resistant bacteria, and the overuse of antibiotics leads to negative consequences. The current study used different literature resources to generate an opinion and find a possible solution to antibiotic barriers. Different scientific approaches have been reported to overcome antibiotic resistance. The most useful approach among these is nanotechnology. Nanoparticles can be engineered to disrupt bacterial cell walls or membranes, effectively eliminating resistant strains. Additionally, nanoscale devices enable the real-time monitoring of bacterial populations, allowing for the early detection of resistance emergence. Nanotechnology, along with evolutionary theory offers promising avenues in combating antibiotic resistance. Evolutionary theory helps us understand the mechanisms by which bacteria develop resistance, allowing us to anticipate and counteract their adaptive strategies. By studying the selective pressures that drive resistance, we can therefore design more effective interventions or traps. The synergy between the evolutionary theory and nanotechnology presents a powerful approach to combat antibiotic resistance, offering new avenues for the development of effective treatments and the preservation of our antibiotic arsenal.

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“…In addition, swine wastewater is an important source of antibiotic-resistant genes (ARGs), antibiotic-resistant bacteria, and virulence factor genes [18]. Liu et al [19] studied the ecological risk of toxic metal elements and antibiotics in swine wastewater in Shandong Province and found that the iron and zinc pollution in the wastewater was serious, and the comprehensive pollution indices were 708.94 and 3.13, respectively. At the same time, drug-resistant Escherichia coli was detected in all cities of the province, and the genes resistant to quinolones, tetracyclines, sulfonamides, aminoglycosides, and β-lactam antibiotics were all above 60%.…”

Section: Pollution Characteristics Of Swine Wastewatermentioning

confidence: 99%

Research Advancements in Swine Wastewater Treatment and Resource-Based Safe Utilization Management Technology Model Construction

Chen,

Zhu,

et al. 2024

Water

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Swine wastewater contains large amounts of organic matter, nutrients, toxic metal elements, and antibiotics. If it is directly discharged or not properly treated, it poses a significant threat to the environment and human health. Currently, the management of swine wastewater has become a focus of social attention, and it adopts a dual-track parallel model of standard discharge supplemented by resource utilization. If treated properly, it can achieve the recycling of water resources and promote the effective recovery of resources. Based on the pollution characteristics of swine wastewater, this paper analyzes its impact on the environment, society, and the economy in detail and expounds on the research progress of swine wastewater treatment technology. From the perspective of resource utilization and recycling of anaerobic digestion liquid (biogas slurry) from swine wastewater and the carrying capacity of the soil environment and cumulative ecological environmental risks, this study explores new development trends and application prospects for swine wastewater treatment technology.

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Ecological risk under the dual threat of heavy metals and antibiotic resistant Escherichia coli in swine-farming wastewater in Shandong Province, China

Cited by 26 publications

References 63 publications

Unveiling Antibiotic Resistance, Clonal Diversity, and Biofilm Formation in E. coli Isolated from Healthy Swine in Portugal

Unveiling Antibiotic Resistance, Clonal Diversity, and Biofilm Formation in E. coli Isolated from Healthy Swine in Portugal

Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Research Advancements in Swine Wastewater Treatment and Resource-Based Safe Utilization Management Technology Model Construction

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